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12 Cards in this Set
- Front
- Back
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What is the pathogenesis of the rash associated with chickenpox?
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The rash begins on the face first and then spreads down towards the abdomen and trunk. The lesions are tiny, fluid-filled vesicles that ultimately dry up and crust over.
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Where does VZV usually become latent after primary infection?
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It becomes latent within the neurons of the dorsal root ganglia of peripheral nerves.
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When would you get a reactivation of VZV?
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If cellular immunity wanes, VZV can reactivate and infect the dermatome served by the sensory nerve it was latent in. This disease is known as Zoster or Shingles.
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Should the Chickenpox vaccine be given to children with HIV?
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Yes, it has been documented to be safe. There are severe complications that are common with chickenpox and zoster in HIV positive children.
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In which population is Zoster most common with?
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Elderly patients. It can cause significant morbidity and post-herpetic neuralgia.
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What vaccine should elderly people be given?
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The Zoster vaccine that contains a high potency of live, varicella virus.
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Should a susceptible adult that just contacted a child with chickenpox receive the chickenpox vaccine?
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Yes, post-exposure immunization can prevent natural chickenpox if the vaccine is given within the first few days after contact.
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Is the chickenpox vaccine approved for use in immunocompromised patients?
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NO
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Can vaccination make you susceptible to Zoster later in life?
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Yes but it is a less severe form of Zoster than that associated with natural infection.
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Why might older individuals be at potential risk of developing chickenpox later in life?
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Universal childhood immunization reduces the transmission of VZV and thus gets rid of the boosting effect of exposure to the virus in immunized individuals. Adults immunity against VZV may wane with time making them more susceptible to chickenpox later in light.
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What is the time-line of vaccination for chickenpox?
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The vaccine is given to healthy children at 15-18 months and a second dose is given at 4-6 years old.
Non-immune adults require 2 doses as well (provides immunity for about 6 years). |
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What population is the Zoster vaccine targeted at?
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Older individuals (>60) who have had chickenpox in their youth and whose immunity needs to be boosted to reduce the risk of them developing herpes zoster.
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