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23 Cards in this Set
- Front
- Back
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leucovorin rescue
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methotrexate
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macrovesicular fatty change in liver
mucositis teratogenic |
methotrexate
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thymidine rescue
photosensitivity |
5-FU
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metabolized by xanthine oxidase, therefore increased toxicity with allopurinol
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6-MP
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can be given with allopurinol for ALL
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6-TG
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inhibits DNA polymerase
leukopenia, thrombocytopenia megaloblastic anemia |
ara-C
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leads to myelosuppression
Wilms tumor, Ewing's, rhabdomyosarcoma |
Dactinomycin
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cardiotoxcity
alopecia |
doxorubicin
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pulmonary fibrosis, skin changes
(induces fre radicals//breaks in DNA strands) |
bleomycin
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inhibits topoisomerase II --> increased DNA degradation
myelosuppression, GI irritation, alopecia |
etoposide (VP-16)
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hemorrhagic cystitis (prevented with mesna)
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cyclophosphamide
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CNS toxcity
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Nitrosoureas
(carmustine, lomustine, semustine, streptozocin) |
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pulmonary fibrosis, hyperpigmentation
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busulfan
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neurotoxicity, areflexia, paralytic ileus
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vincristine
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bone marrow suppression; used for Hodgkin's lymphoma, Wilms', choriocarcinoma
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vinblastine
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myelosuppression and hypersensitivity; for ovarian and breast carcinomas
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paclitaxel
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nephrotoxicity, acoustic nerve damage
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cisplatin, carboplatin
(tx: amifostine) |
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cataracts, acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis
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prednisone
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endometrial carcinoma risk
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tamoxifen
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monoclonal ab against over expressed HER-2 (erb-2)
cardiotoxicity |
trastuzumab (herceptin)
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fluid retention; used for CML, GI stromal tumors
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imatinib (gleevac)
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monoclonal ab against CD20 for nHL, RA (with MTX)
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rituximab
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induces wasting syndrome, paraneoplastic
suppresses appetite inhibits LPL increases insulin resistance of peripheral tissues |
TNF-a
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