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74 Cards in this Set
- Front
- Back
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Which drugs attack purine synthesis
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6-mercaptopurine
6-thioguanine methotrexate |
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Which drugs attack pyrimidine synthesis
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PALA
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Which drugs attack ribonucleotides
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6-mercaptopurine
6-thioguanine hydroxyurea |
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Which drugs attack deoxyribonucleotides
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methotrexate
5-fluorouracil |
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Which drugs attack DNA via topoisomerase inhibition
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camptothecins
etoposide teniposide daunorubicin doxorubicin |
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Which drugs attack DNA by forming DNA adducts
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platinum analogs
alkylating agents mitomycin cisplatin temozolomide |
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Which drugs block enzyme action and signaling
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protein tyrosine kinase inhibitors
bortezomib antibodies |
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Which drugs attack protein synthesis
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L-asparginase
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Which drugs attack microtubules
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paclitaxel
vinca alkaloids colchicine estramustine |
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What is the mechanism of 6-mercaptopurine
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blocks purine synthesis
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What is the DLT of 6-mercaptopurine
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BMS
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What is the mechanism of methotrexate
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Blocks dihydrofolate reductase thereby blocking thymidine sythesis
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What is the DLT of methotrexate
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Renal
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What is the mechanism of doxorubicin
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stabilizes topoisomerase II and DNA bond resulting in double strand break
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What is the DLT of doxorubicin
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Cardio - effects are cumulative
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What is the mechanism of daunorubicin
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stabilizes topoisomerase II and DNA bond resulting in double strand break
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What is the DLT of daunorubicin
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Cardio - effects are cumulative
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What is the mechanism of etoposide
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stabilizes topoisomerase II and DNA bond resulting in double strand break
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What is the DLT of etoposide
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BMS and N&V
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What is the mechanism of irinotecan
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Inhibits topoisomerase I resulting in double strand breaks
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What is the DLT of irinotecan
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BMS
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What is the mechanism of trastuzamab
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blocks HER-2 receptor
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What is the DLT of trastuzamab
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pulmonary
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What is the mechanism of cetuximab
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blocks EGFR receptor
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What is the DLT of cetuximab
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dermitologic
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What is the mechanism of rituximab
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binds to CD20
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What is the DLT of rituximab
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renal
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What is the mechanism of bevacizumab
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blocks VEGF receptor
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What is the DLT of bevacizumab
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hypertension
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What is the mechanism of imatinib
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inhibits BCR-ABL protein
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What is the DLT of imatinib
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N&V
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What is the mechanism of lapatinib
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blocks EGFR and HER-2/NEU
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What is the DLT of lapatinib
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diarrhea
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What is the mechanism of sunitinib
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blocks TYR-KIN
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What is the DLT of sunitinib
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CV
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What is the mechanism of gefitinib
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EGFR-TKI
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What is the mechanism of sorafenib
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inhibits RAF/MEK and VEGFR
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What is the DLT of sorafenib
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BMS
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What is the mechanism of vemurafenib
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inhibits RAF
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What is the DLT of vemurafenib
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joint pain
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What is the mechanism of tretinoin (ATRA)
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causes cell differentiation
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What is the DLT of tretinoin (ATRA)
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retinoic acid syndrome
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What is the mechanism of bleomycin
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causes free radicals in the DNA
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What is the DLT of bleomycin
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lung and skin fibrosis
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What is the mechanism of dactinomycin
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uncoils DNA
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What is the DLT of dactinomycin
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myelosuppression
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What is the mechanism of vincristine
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causes microtubule instability
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What is the DLT of vincristine
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peripheral neuropathy
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What is the mechanism of vinblastine
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causes microtubule instability
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What is the DLT of vinblastine
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myelosuppression
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What is the mechanism of paclitaxel
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stabilizes microtubule assembly
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What is the DLT of paclitaxel
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neutropenia
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What is the mechanism of bortezomib
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inhibits 26S proteasome
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What is the DLT of bortezomib
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GI
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What is the mechanism of L-asparginase
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depletes L-asparagine blocking protein synthesis
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What is the DLT of L-asparginase
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pancreatitis
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What is the mechanism of tamoxifen
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binds estrogen receptor
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What is the DLT of tamoxifen
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N&V
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What is the mechanism of anastrozole
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blocks estradiol production
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What is the DLT of anastrozole
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N&V
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What is the mechanism of hydroxyurea
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blocks DNA synthesis
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What is the DLT of hydroxyurea
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BMS
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What is the mechanism of 5-fluorouracil
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blocks thymidine synthesis
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What is the DLT of 5-fluorouracil
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BMS
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What is the mechanism of cytosine arabinoside
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Blocks DNA synthesis
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What is the DLT of cytosine arabinoside
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myelosuppression
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What is the mechanism of temozolomide
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forms DNA adducts
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What is the DLT of temozolomide
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BMS
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What is the mechanism of nitrogen mustards
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Cross links DNA
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What is the DLT of nitrogen mustards
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BMS
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What is the mechanism of platinum compounds
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Cross links DNA
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What is the DLT of platinum compounds
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nephro, neuro, oto
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What drugs are nitrogen mustards
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mechlorethamine
cyclophosphamide bendamustine |
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What drugs are platinum compounds
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cisplatin
carboplatin oxaliplatin |
