Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
Cyclophosphamide
|
M-niitrogen mustard crosslinking to N7 position via N moietes
T-BM Leukpenia, thrombocytopenia P-Non-spec. |
|
|
MESNA
|
Inhibits cyclophosamide
|
|
|
Cisplatin
|
platinum analog to cyclophosphamide
Renal toxicity Non-spec. |
|
|
Bleomycin
|
cleaves DNA strands by free radicals
pulmonary toxicity M, G2 |
|
|
Doxorubicin
|
Freezes topoisomerase II
BMS(leukopenia and thrombocytopenia), cardiac toxicity non-spec |
|
|
Methotrexate
|
BMS(leukopenia and
thrombocytopenia), S |
|
|
Leucovorin
|
rescue for thymidylate synthase
|
|
|
Fluoruracil
|
pyrimidine analog: inhibits thymidylate synthase
non-spec |
|
|
Levamisole
|
drug formly used in combination with fluorouracil to treat colon cancer. No known mechanism for this action...antibiotic
|
|
|
Mercaptopurine
|
purine analog. Feedback inhibition of 1st step.
BMS S |
|
|
Paclitaxel
|
Mitosis inhibitor:prevents spindles segregation?
Neutropenia M..G2? |
|
|
Tamoxifen
|
estrogen receptor binder
anti-estrogen breast, estrogenic bone/endometrium pre-menopause |
|
|
Raloxifene
|
estrogen receptor binder
anti-estrogen breast/endometrium, estrogenic bone pre-menopause |
|
|
Fulvestrant
|
estrogen receptor binder and induces downregulation
post-menopause |
|
|
Herceptin(Her2geneproduct)
|
transmembrane receptor w/ tyrosine
CHF and decreased left ventricular ejection |
|
|
Letrozole
|
estrogen receptor binder
All anti-effects(breast, endometrium, bone) post-menopause |
|
|
Aminoglutethimide
|
antiadrenal andro. Inhibits cholesterol to pregnenolone
lethargy, skin rashes and ataxia |
|
|
Diethylstibestrol
|
Feedback inhibition of LH and FSH
Gynecomastia and impotence |
|
|
Leuprolide
|
GnRH superagonist (desensitized) causing feedback inhibition
bone pain, hot flashes, gynecomastia |
|
|
Flutamide
|
anti-androgen
osteoporosis, gnecomastic decreased libido/sperm |
|
|
Prednisone
|
synthetic glucocorticoid inducing apoptosis voa g;icpcprtocpod receptor
Hyperadrenocorticism. Acute tumor lysis syndrome: hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute renal failure NO BMD so good for combinations. |
|
|
Gleevec
|
spec. inhibits bcr-Abl, kit and PDGF tyrosine kinases
mild malaise. Possible teratogen |
|
|
TYKERB
|
EGFR-1/2 inhibitor
Hepatoxicity, fetal harm. |
