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35 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Mechlorethamine |
Alkylating nitrogen mustard -lacks ring structure |
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Cyclophosphamide* |
Alkylating nitrogen mustard *most widely used alkylating agent -activated by CYP2B -acute myelosuppression |
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Ifosfamide |
Alkylating nitrogen mustard -similar to cyclophosphamide -activated by CYP3A4 -activated more slowly therefore requires higher dose --> increased risk of cytotoxicity -acute myelosuppression |
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Melphalan |
Alkylating nitrogen mustard |
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Chlorambucil |
-Alkylating nitrogen mustard. -More stable and orally available than Mechlorethamine . -acute myelosuppression |
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Hexamethylamine |
Alyklating ethlinimine |
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Thiotepa |
Alyklating Methilinimine |
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Busulfan |
Alkylating sulfonate |
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Carmustine |
Alkylating nitosource |
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Lomustine |
Alkylating nitosource |
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Streptozotocin |
Alkylating nitosource -antibiotic |
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Dacarbazine |
Alkylating triazine -adds methyl group to DNA -activated by CYP -prototype |
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Temozolomide |
Alkylating triazine |
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Methotrexate |
Antimetabolite: folic acid analog Treats: RA MOA: 1)inhibits DHFR --> S phase in B and T cells 2) block thymidylate and purine synthesis
Adverse: hepatotoxicity, myelosuppression, GI effects |
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5-FU |
Anti metabolite pyramidine analog Inhibit thymidylate synthesis |
5-flurouridine |
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Floxuridine |
Anti metabolite pyramidine analog |
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Cytarabine |
Anti metabolite pyramidine analog |
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6-Mercaptopurine |
Anti metabolite purine analog MOA: inhibit purine synthesis |
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Thioguanine |
Anti metabolite purine analog |
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Cladribine |
Anti metabolite purine analog |
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Fludarabine |
Anti metabolite purine analog |
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Vinca alkaloids |
Vincristine, vinblastine, vinorelbine
Anti-mitotic agents |
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Paclitaxel |
Anti-mitotic taxane. Stabilizes microtubule--> tubulin polymerization. Inhibits M phase Myelosuppression dose limiting |
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Docetaxel |
Anti-mitotic taxane. Stabilizes microtubule--> tubulin polymerization. Inhibits M phase Myelosuppression dose limiting |
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Topotecan |
Binds topoisomerase I |
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Irinotecan |
Binds topoisomerase I |
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Etoposide |
Epipodophyllotoxin MOA: binds Topoisomerase II |
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Teniposide |
Epipodophyllotoxin MOA: binds Topoisomerase II |
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Doxorubicin |
Anthracycline/tumor antibody MOA: binds Topoisomerase II |
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Epirubicin |
Anthracycline/tumor antibody MOA: binds Topoisomerase II |
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Danunorubicin |
Anthracycline/tumor antibody MOA: binds Topoisomerase II |
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Idarubicin |
Anthracycline/tumor antibody MOA: binds Topoisomerase II |
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Mitomycin |
Tumor antibody |
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Bleomycin |
Tumor antibody |
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Dactinomycin |
Tumor antibody |
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