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24 Cards in this Set
- Front
- Back
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Nitrogen Mustards
Cylophosphamide Mechorethamine Chlorambucil Carmustine Lomustine |
Alkylating Agents
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Transfer alkyl group to cellular molecules
Covalent irreversible bond to DNA Crosslink DNA Guanine is the target |
Alkylating Agents
MOA |
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Cisplatin
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"Fake" alkylating agent
Similar in effect (DNA binding) |
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Mitomycin
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"Fake" alkylating agent
Binds DNA and causes strand breakage |
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Block normal synthetic process of DNA
Subs for normal substrates in DNA synthesis Prevents synthesis Produces defective DNA |
Antimetabolites
MOA |
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6 Mercaptopurine (A)
Thioguanine (G) |
Antimetabolits
Purine Analogs |
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Bind to and inhibit enzymes necessary for synthesis of guanine and adenine nucleotides
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Purine Analogs
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5 Fluorouracil (T)
Cytosine arabinoside (C) |
Antimetabolites
Pyrimidine Analogs |
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Bind to and inhibit enzymes necessary for synthesis of thymidine and cytosine nucleotides
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Pyrimidine Analogs
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Methotrexate
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Folic Acid Analogs
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Bind and inhibit dihydrofolate reductase; inhibits thymidine synthesis
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Folic Acid Analogs
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Vinblastine
Vincristine Paclitaxel |
Mitotic Inhibitors
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Mitotic Inhibitors
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Disruption of chromosone seperation in mitosis
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Etoposide
Teniposide |
DNA Topoisomerase Inhibitors
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DNA Topoisomerase Inhibitors
MOA |
Inhibits bacterial DNA topoisomerase critical in DNA maintainence and replication
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Hormonal Agents
MOA |
Antagonist inhibits endogenous hormone agonist that enhances cell replication
Agonist mimic endogenous hormone agonist that slows cell replication |
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Diethylstibestrol
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Agonist at estrogen receptors
Used for prostate gland cancer and breast cancer Side Effect=feminization in males |
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Testosterone
Fluoxymestrone |
Agonist at androgen receptors
Used for breast cancer Side Effects=edema and masculinization in females |
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Hydroxyprogesterone
Medroxyprogesterone Megestrol |
Agonist at progestin receptors
Used for renal carcinoma and endometrial carcinoma Side Effect=same as when in contraceptives |
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Prednisone
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Agonist at glucocorticoid receptors
Used for childhood leukkemia, lymphoma and breast cancer Side Effects=osteoporosis, fluid retention, hypertension, hyperglycemia |
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Tamoxifen
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Estrogen receptor antagonist
Used for breast cancer |
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Flutamide
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Androgen receptor antagonist
Used in metastatic prostate cancer |
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Erlotinib
Imatinib |
Tyrosine Kinase Inhibitors
Inhibits signal transduction pathways Useful in some tumors |
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Rituximab
Trastuzumab Bevacizumab |
Monoclonal Anitbodies
Causes cell death Antibody targets growth factor of tumors |
