Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
MOA for alkylating agents?
|
DNA cross linking and strand breaks cause disruption of replication and apoptosis
|
|
|
MOA for ATRA?
|
induces maturation of promyelocytes
|
|
|
MOA for antrhacyclines?
|
non covalent DNA binding causes: stabilize topo II, strand breaks, RNA synth interference
|
|
|
MOA of antimetabolites?
|
analogues and MTX is block pur/pyr synth
|
|
|
MOA for arsenic/
|
degrades RAR/PML fusion protein
|
|
|
MOA of taxanes and vincas?
|
microtubule inhibitors cause metaphase arrest
|
|
|
What is typhlitis?
|
infx of cecum and proximal asc colon that can be life threatening w/in hrs
|
|
|
How do you prevent neutropenic fever?
|
give G-CSF (neupogen) and GM-CSF (leukine)
|
|
|
Explain drug resistance via drug efflux?
|
upregulation of MRP or MDR1 which is a gene on chr 7 that encodes for a pump that can extrude drugs
|
|
|
Where is the drug efflux pump found?
|
BBB, gut, kidney , hepatobiliary tree
|
|
|
What can combat drug resistance due to efflux pumps?
|
CCBs, cycloA, phenothiazines, quinidine
|
|
|
Explain drug resistance due to gene amp?
|
upregulate an enzyme that is normally inhibited by a drug
|
|
|
Explain drug resistance due to increased glutathione.
|
detoxifies intermediates
|
|
|
Explain drug resistance due to polyglutamation.
|
decreased polyglut or increased hydrolase favors loss of drug from cell
|
|
|
How do you prepare a pt for BMT?
|
Total body irradiation plus high dose cyclophos or cyclo+busulfan
|
|
|
How do you prepare a donor for periph stem cell donation?
|
5-6 days of G-CSF
|
|
|
Side effects for peripheral stem cell donors?
|
bone pain, paresthesias
|
|
|
Side effects of BMT?
|
sterility,
|
|
|
Side effect of cyclophosphamide? How prevent?
|
hemorrhagic cystitis, prevent w/hydration and bladder irrigation
|
|
|
Where are the major targets of GVHD?
|
skin, GI, bile ducts
|
|
|
Tx for GVHD?
|
corticosteroids, immunosuppressives
|
|
|
How does a GVHD pt die?
|
infx due to compromised skin/mucosal barriers
|
|
|
What is the first stage of immunodeficiency in BMT?
|
neutropenia wks-mth, bact/fung/HSV (propho w/acyclovir)
|
|
|
What is the second stage of immunodeficiency in BMT?
|
t-cell def 2-12mths, reactivating viruses (CMV propho w/gancyclovir)
|
|
|
What is the third stage of immunodef in BMT?
|
6mth-sevyears. Humoral def. Encapsulated organisms
|
|
|
What is chronic GVHD?
|
post 100 days, autoimmune inflammatory fibrotic. Resembles scleroderma and primary biliary cirrhosis
|
