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17 Cards in this Set
- Front
- Back
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Most common AE of cyclophosphamide
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NAHM:
-nausea&vomiting -alopecia -hemorrhagic cystitis (take mesna!) -myelosuppresion |
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What type of drug is cyclophosphamide
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alkylating
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Basic MOA of cisplatin
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Cisplatin is made up of a Platinum analog! The drug binds to DNA and causes cross-linking using guanine --> stop DNA replication!
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Major toxicity of cisplatin
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MN RAN
-myelosuppression -NAUSEA&VOMITING (EXTREME!) -renal dysfn (give electrolytes) -acoustic nerve dysfn -neurotoxicity/ototoxicity |
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What does methotrexate inactivate?
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folic acid
(it's part of the antimetabolites group) |
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What are the toxicities of methotrexate?
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dms
-diarrhea -myelosuppresion -stomatitis (oral/GI ulcerations) |
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What should be given with methotrexate?
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leucovorin (rescues the bone marrow - provides folic acid to the normal cells and NOT the malignant cells)
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Basic MOA of vincristine.
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vinca alkaloids - binds to tubulin and terminates microtubule assembly --> halts mitosis (interrupts mitosis/cell division)
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What medication would you give to someone with lymphomas?
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vincristine!
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What are the toxicities of vincristine?
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crain
-CONSTIPATION -reproductive dysfn -alopecia -injection site necrosis -neuromuscular deficits (cn dysfn, loss of DTR, motor weakness) |
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most common AEs of doxorubicin
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IC SAM
-infusion reactions (10% - flushing, facial swelling, SOB, hypotension, back pain) -Cardiotoxic (acute-change on EKG & arrhythmias) (chronic-cardiomyopathy -> signs of CHF) -stomatitis -alopecia -myelosuppresion (dose-limiting) |
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name the abx we need to know. (for cancer)
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doxorubicin
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MOA of doxorubicin
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intercalates w/DNA causing breaks
+ generates DNA damaging free radicals |
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Tamoxifen, what is it?
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antiestrogen
selective estrogen receptor modulator! |
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use of tamoxifen?
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estrogen receptor positive breast cancer tx + prevention in high risk pts
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MOA of tamoxifen?
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-blocks estrogen reeptors
-starves tumor cells that grow b/c of estrogen |
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When to give tamoxifen?
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-treat breast ca (suppress ca cell growth following surgery
-prevention of breast cancer (those at high risk |
