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31 Cards in this Set

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Chemotherapy: Cisplatin
ALKYLATING AGENT
Substitutes alkyl groups for hydrogen atoms in DNA
Causes both inter- and intrastrand DNA crosslinking
Inhibits DNA synthesis
More toxic to HYPOXIC cells but not as powerful as nitroimidazoles
Chemotherapy: Carboplatin
ALKYLATING AGENT
Similar to Cisplatin
Less toxic
Chemotherapy: Cyclophosphamide
ALKYLATING AGENT
Substitutes alkyl groups for hydrogen atoms in DNA
Causes both inter- and intrastrand DNA crosslinking
Inhibits DNA synthesis
Chemotherapy: Alkylating Agents
Substitute alkyl groups for hydrogen atoms in DNA
Cause both inter- and intrastrand DNA crosslinking
Inhibit DNA synthesis
Chemotherapy: 5-FU
Tumor cells utilize 5-FU preferentially over uracil
Inhibits DNA synthesis
Chemotherapy: Docetaxel
TAXANE - Taxotere
Derived from pine needles of Pacific Yew trees
Stabilization of microtubules prevents separation of chromosomes during anaphase

Paclitaxel = Taxol
Chemotherapy: Doxorubicin
ANTIBIOTIC (Adriamycin)
Directly binds to DNA
Inhibits DNA and RNA synthesis
Chemotherapy: Etoposide
PODOPHYLLOTOXIN
Derived from American Mayapple
Prevents the cells from entered G1 and S phases
Mechanism still not clear
Chemotherapy: Irinotecan
TOPOISOMERASE INHIBITOR
Dirupts proper DNA supercoiling
Interferes with transcription and replication of DNA
Degraded by p450
p450 increased by Dilatin, carbamazepine
Chemotherapy: Mitomycin C
ANTIBIOTIC (Mutamycin)
Activated in ivo to multifunctional alkylating agent

More toxic to HYPOXIC cells
Chemotherapy: Paclitaxel
TAXANE (Taxol)
Derived from European Yew trees
Stabilization of microtubules prevents separation of chromosomes during anaphase
Chemotherapy: Vinblastine
VINCA ALKALOID
Derived from Catharanthus roseus
Binds to specific sites on tubulin
Prevents assembly of tubulin into microtubules in M phase
Chemotherapy: Vincristine
VINCA ALKALOID
Derived from Catharanthus roseus
Binds to specific sites on tubulin
Prevents assembly of tubulin into microtubules in M phase
Chemotherapy: Vinca alkaloids
Binds to specific sites on tubulin
Prevents assembly of tubulin into microtubules in M phase
Chemotherapy: Taxanes
Stabilization of microtubules prevents separation of chromosomes during anaphase
Chemotherapy: Bevacizumab
Anti-VEGF antibody (Avastin)
Binds to and neutralizes human vascular endothelial growth factor (VEGF)

Side effects
- HTN (severe 24%)
- Arterial and DVT (severe 3-10%)
- Alopecia (32%)
- Hemorrhage in lung cancer trials
Chemotherapy: Sutent
Multi-targeted tyrosine kinase receptor inhibitor
Inhibits
- Platelet-derived endotheial growth factors
- VEGF receptors

Side effects
- HTN (52%)
- LV dysfcn (14%)
- GI 50%
Chemotherapy: Trastuzumab
Antibody (Herceptin)
Selective monoclonal antibody for HER2
Inhibits proliferations of HER2 overexpressing tumor cells

Side effects
- Cardiac dysfcn (4%)
Chemotherapy: Capecitabine
Capecitabine (Xeloda)

Converted to 5FU in tumor
Primary uses
- Metastatic breast cancer
- Metastatic colorectal cancer

Inhibits DAN synthesis
Chemotherapy: Dacarbazine
ALKYLATING AGENT

Alkylates and crosslinks DNA in all cell cycle phases
Chemotherapy: Bleomycin
ANTIBIOTIC from Strep verticillus

Complexes with iron -->
Superoxide and OH radicals -->
SSB and DSBs
Chemotherapy: Mechlorethamine
ALKYLATING AGENT

Nitrogen mustard
- Crosslinks
- Mismatch
- Decreased repair
Chemotherapy: Temsirolimus
Torisel - mTor inhibitor for RCC
mTor --> Cyclin D & Hif-1a -->
VEGF
Results
- Cell cycle arrest in G1
- Decreased angiogenesis
Sunitinib
Sutent
Indications
- RCC
- Imatinib-resistant GIST
Multitargeted RTK (receptor tyrosine kinase) inhibitor
- PDGF-R
- VEGF-R
Result: Decreased angiogenesis
Sorafenib
Nexavar
Indications
- Advanced RCC
- Advanced HCC
Mechanism
- Raf/Mef/Erk pathway
- PDGF/VEFT inhibition
Gemcitabine
Nucleoside analog

Replaces cytidine

Causes apoptosis
ABVD
Adriamycin
Bleomycin
Vinblastine
Dacarbazine
RCHOP
Rituximab
Cyclophosphamide
Hydroxydaunorubicin (Adria)
Prednisone
MOPP
Mechlorethamine
Oncovorin (Vcr)
Procarbazine
Prednisone
Stanford V
Adriamycin
Bleomycin
Vinblastine
Mechlorethamine
Oncovorin (Vcr)
Prednisone
Etoposide
ABV-MOPE rhymes with Hoppe
Prednisone
BEACOPP
Bleomycin
Etoposide
Adriamycin
Cyclophosphamide
Oncovorin
Prednisone
Procarbazine