Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
|
Chemotherapy: Cisplatin
|
ALKYLATING AGENT
Substitutes alkyl groups for hydrogen atoms in DNA Causes both inter- and intrastrand DNA crosslinking Inhibits DNA synthesis More toxic to HYPOXIC cells but not as powerful as nitroimidazoles |
|
|
Chemotherapy: Carboplatin
|
ALKYLATING AGENT
Similar to Cisplatin Less toxic |
|
|
Chemotherapy: Cyclophosphamide
|
ALKYLATING AGENT
Substitutes alkyl groups for hydrogen atoms in DNA Causes both inter- and intrastrand DNA crosslinking Inhibits DNA synthesis |
|
|
Chemotherapy: Alkylating Agents
|
Substitute alkyl groups for hydrogen atoms in DNA
Cause both inter- and intrastrand DNA crosslinking Inhibit DNA synthesis |
|
|
Chemotherapy: 5-FU
|
Tumor cells utilize 5-FU preferentially over uracil
Inhibits DNA synthesis |
|
|
Chemotherapy: Docetaxel
|
TAXANE - Taxotere
Derived from pine needles of Pacific Yew trees Stabilization of microtubules prevents separation of chromosomes during anaphase Paclitaxel = Taxol |
|
|
Chemotherapy: Doxorubicin
|
ANTIBIOTIC (Adriamycin)
Directly binds to DNA Inhibits DNA and RNA synthesis |
|
|
Chemotherapy: Etoposide
|
PODOPHYLLOTOXIN
Derived from American Mayapple Prevents the cells from entered G1 and S phases Mechanism still not clear |
|
|
Chemotherapy: Irinotecan
|
TOPOISOMERASE INHIBITOR
Dirupts proper DNA supercoiling Interferes with transcription and replication of DNA Degraded by p450 p450 increased by Dilatin, carbamazepine |
|
|
Chemotherapy: Mitomycin C
|
ANTIBIOTIC (Mutamycin)
Activated in ivo to multifunctional alkylating agent More toxic to HYPOXIC cells |
|
|
Chemotherapy: Paclitaxel
|
TAXANE (Taxol)
Derived from European Yew trees Stabilization of microtubules prevents separation of chromosomes during anaphase |
|
|
Chemotherapy: Vinblastine
|
VINCA ALKALOID
Derived from Catharanthus roseus Binds to specific sites on tubulin Prevents assembly of tubulin into microtubules in M phase |
|
|
Chemotherapy: Vincristine
|
VINCA ALKALOID
Derived from Catharanthus roseus Binds to specific sites on tubulin Prevents assembly of tubulin into microtubules in M phase |
|
|
Chemotherapy: Vinca alkaloids
|
Binds to specific sites on tubulin
Prevents assembly of tubulin into microtubules in M phase |
|
|
Chemotherapy: Taxanes
|
Stabilization of microtubules prevents separation of chromosomes during anaphase
|
|
|
Chemotherapy: Bevacizumab
|
Anti-VEGF antibody (Avastin)
Binds to and neutralizes human vascular endothelial growth factor (VEGF) Side effects - HTN (severe 24%) - Arterial and DVT (severe 3-10%) - Alopecia (32%) - Hemorrhage in lung cancer trials |
|
|
Chemotherapy: Sutent
|
Multi-targeted tyrosine kinase receptor inhibitor
Inhibits - Platelet-derived endotheial growth factors - VEGF receptors Side effects - HTN (52%) - LV dysfcn (14%) - GI 50% |
|
|
Chemotherapy: Trastuzumab
|
Antibody (Herceptin)
Selective monoclonal antibody for HER2 Inhibits proliferations of HER2 overexpressing tumor cells Side effects - Cardiac dysfcn (4%) |
|
|
Chemotherapy: Capecitabine
|
Capecitabine (Xeloda)
Converted to 5FU in tumor Primary uses - Metastatic breast cancer - Metastatic colorectal cancer Inhibits DAN synthesis |
|
|
Chemotherapy: Dacarbazine
|
ALKYLATING AGENT
Alkylates and crosslinks DNA in all cell cycle phases |
|
|
Chemotherapy: Bleomycin
|
ANTIBIOTIC from Strep verticillus
Complexes with iron --> Superoxide and OH radicals --> SSB and DSBs |
|
|
Chemotherapy: Mechlorethamine
|
ALKYLATING AGENT
Nitrogen mustard - Crosslinks - Mismatch - Decreased repair |
|
|
Chemotherapy: Temsirolimus
|
Torisel - mTor inhibitor for RCC
mTor --> Cyclin D & Hif-1a --> VEGF Results - Cell cycle arrest in G1 - Decreased angiogenesis |
|
|
Sunitinib
|
Sutent
Indications - RCC - Imatinib-resistant GIST Multitargeted RTK (receptor tyrosine kinase) inhibitor - PDGF-R - VEGF-R Result: Decreased angiogenesis |
|
|
Sorafenib
|
Nexavar
Indications - Advanced RCC - Advanced HCC Mechanism - Raf/Mef/Erk pathway - PDGF/VEFT inhibition |
|
|
Gemcitabine
|
Nucleoside analog
Replaces cytidine Causes apoptosis |
|
|
ABVD
|
Adriamycin
Bleomycin Vinblastine Dacarbazine |
|
|
RCHOP
|
Rituximab
Cyclophosphamide Hydroxydaunorubicin (Adria) Prednisone |
|
|
MOPP
|
Mechlorethamine
Oncovorin (Vcr) Procarbazine Prednisone |
|
|
Stanford V
|
Adriamycin
Bleomycin Vinblastine Mechlorethamine Oncovorin (Vcr) Prednisone Etoposide ABV-MOPE rhymes with Hoppe Prednisone |
|
|
BEACOPP
|
Bleomycin
Etoposide Adriamycin Cyclophosphamide Oncovorin Prednisone Procarbazine |
