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40 Cards in this Set
- Front
- Back
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cyclophosphamide
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alkylating agent
DLT: liver problems!! |
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mephlalan
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alkylating agent
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chlorambucil
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alkylating agent
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carmustine
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alkylating agent
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lomustine
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alkylating agent
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streptozocin
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alkylating agent
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thiotepa
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alkylating agent
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busulfan
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alkylating agent
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decarbazine
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alkylating agent
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cisplatin
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platinum alkylating agent
DLT: nephrotoxicity |
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carboplatin
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platinum alkylating agent
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methotrexate
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antifolate antimetabolite
inhibits DHFR |
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mercaptopurine
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antipurine antimetabolite
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thioguanine
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antipurine antimetabolite
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fludarabine
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antipurine antimetabolite
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fluorouracil
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inhibits thymidylate synthetase
resistance: increaesed expr of thymidylate synthetase contradind: DPD deficiency capecitabine is similar but with longer halflife (prodrug) |
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cytarabine
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antipyrimidine antimetabolite
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gemcitabine
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antipyrimidine antimetabolite
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vinblastine
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vinca alkyloid - spindle poison
MOA: inhibits microtubule polymerization DLT: myelosuppression |
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vincristine
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vinca alkyloid - spindle poison
MOA: inhibits microtubule polymerization *** vincristine is marrow sparing! DLT: neurotoxicity |
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etoposide
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plant alkyloid
___poside MOA: Topoisomerase II inhibitor, causes DNA strand breaks and cycle arrest DLT: myelosuppresion, N/V, alopecia MOR: for alkyloids, tends to be glycoprotein p efflux pump |
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irinotecan
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plant alkyloid
____tecan MOA: topoisomerase I inhibitor DLT: severe GI problems, diarrhea, mucositis myelosuppression? MOR: for alkyloids, tends to be glycoprotein p efflux pump |
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paclitaxel
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plant alkyloid
___taxel paclitaxel and docetacel: MOA: MT stabilizer DLT: myelosuppression |
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docetacel
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plant alkyloid
____taxel paclitaxel and docetacel: MOA: MT stabilizer DLT: myelosuppression |
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daunorubicin
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antitumor antibiotic
daunorubicin is used for acute leukemias DLT: myelosuppression, cardiotoxicity (not as bad as doxorubicin) MOA: VERY PLEOTROPIC!! 1. inhibits topoisomerase II 2. DNA intercalater 3. alteration in membrane fluidity 4. alteration in ion transport 5. generation of free radicals MoR: pglycoprotein efflux, glutathione conj, topo II mut, DNA repair |
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doxorubicin
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antitumor antibiotic
doxorubicin is used for solid tumors DLT: CARDIAC TOXICITY! myelosuppression MOA: VERY PLEOTROPIC!! MOA: VERY PLEOTROPIC!! 1. inhibits topoisomerase II 2. DNA intercalater 3. alteration in membrane fluidity 4. alteration in ion transport 5. generation of free radicals MoR: pglycoprotein efflux, glutathione conj, topo II mut, DNA repair |
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dactinomycin
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antitumor antibiotic
MOA: intercalates and causes ss strand breaks DLT: myelosuppression, anorexia, N/V, less cardiotoxic than doxorubicin |
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mitomycin
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antitumor antibiotic
crosslinks DNA mighty crosslinking |
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bleomycin
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antitumor antibiotic
use: squamous cell carcinoma of the cervix, lymphoma, testicular tumors MOA: binds copper and iron and causes DNA breaks following free radical attack DLT: pulmonary toxicity |
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IFN alpha
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use: leukemia, sarcoma, squamous cell carcinoma
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IL-2
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use: renal cell carcinoma, malignant melanoma.
MOA: inc. activity of NK cells |
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hydroxyurea
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misc. chemotherapeutic
MOA: inhibit ribonucleotide diphosphate reductase, blocking DNA synthesis NDP's can't be turned into dNDPs.... |
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prednisone
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use: leukemia and lymphoma
inhibits T cell proliferation |
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tamoxifen
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SERM
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leuprolide
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inhibits gonadotropin release, suppressing ovarian and testicular steroidogenesis (gonadotropin-releasing hormone analog)
use: hormone stimulated cancer |
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trastuzumab
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breast cancer chemotherapeutic
inhibits HER2 overexpressing tumor cell proliferation through antibody-dependent cytotoxicity |
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imatinib
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this is Gleevec!! (imagine gleevec)
inhibits TK activity of BCR-ABL use:CML |
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herceptin
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antibody
kills tumors expressing her2/neu (breast cancer) |
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celecoxib
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apoptosis inducer
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thalidomide
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anti angiogenic compound
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