Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/40

Click to flip

40 Cards in this Set

  • Front
  • Back
cyclophosphamide
alkylating agent
DLT: liver problems!!
mephlalan
alkylating agent
chlorambucil
alkylating agent
carmustine
alkylating agent
lomustine
alkylating agent
streptozocin
alkylating agent
thiotepa
alkylating agent
busulfan
alkylating agent
decarbazine
alkylating agent
cisplatin
platinum alkylating agent


DLT: nephrotoxicity
carboplatin
platinum alkylating agent
methotrexate
antifolate antimetabolite

inhibits DHFR
mercaptopurine
antipurine antimetabolite
thioguanine
antipurine antimetabolite
fludarabine
antipurine antimetabolite
fluorouracil
inhibits thymidylate synthetase

resistance: increaesed expr of thymidylate synthetase

contradind: DPD deficiency

capecitabine is similar but with longer halflife (prodrug)
cytarabine
antipyrimidine antimetabolite
gemcitabine
antipyrimidine antimetabolite
vinblastine
vinca alkyloid - spindle poison

MOA: inhibits microtubule polymerization

DLT: myelosuppression
vincristine
vinca alkyloid - spindle poison

MOA: inhibits microtubule polymerization

*** vincristine is marrow sparing!
DLT: neurotoxicity
etoposide
plant alkyloid
___poside
MOA: Topoisomerase II inhibitor, causes DNA strand breaks and cycle arrest

DLT: myelosuppresion, N/V, alopecia

MOR: for alkyloids, tends to be glycoprotein p efflux pump
irinotecan
plant alkyloid

____tecan
MOA: topoisomerase I inhibitor

DLT: severe GI problems, diarrhea, mucositis
myelosuppression?

MOR: for alkyloids, tends to be glycoprotein p efflux pump
paclitaxel
plant alkyloid
___taxel

paclitaxel and docetacel:
MOA: MT stabilizer

DLT: myelosuppression
docetacel
plant alkyloid

____taxel
paclitaxel and docetacel:
MOA: MT stabilizer

DLT: myelosuppression
daunorubicin
antitumor antibiotic

daunorubicin is used for acute leukemias

DLT: myelosuppression, cardiotoxicity (not as bad as doxorubicin)

MOA: VERY PLEOTROPIC!!
1. inhibits topoisomerase II
2. DNA intercalater
3. alteration in membrane fluidity
4. alteration in ion transport
5. generation of free radicals

MoR: pglycoprotein efflux, glutathione conj, topo II mut, DNA repair
doxorubicin
antitumor antibiotic

doxorubicin is used for solid tumors

DLT: CARDIAC TOXICITY! myelosuppression

MOA: VERY PLEOTROPIC!!
MOA: VERY PLEOTROPIC!!
1. inhibits topoisomerase II
2. DNA intercalater
3. alteration in membrane fluidity
4. alteration in ion transport
5. generation of free radicals


MoR: pglycoprotein efflux, glutathione conj, topo II mut, DNA repair
dactinomycin
antitumor antibiotic

MOA: intercalates and causes ss strand breaks

DLT: myelosuppression, anorexia, N/V, less cardiotoxic than doxorubicin
mitomycin
antitumor antibiotic

crosslinks DNA

mighty crosslinking
bleomycin
antitumor antibiotic

use: squamous cell carcinoma of the cervix, lymphoma, testicular tumors

MOA: binds copper and iron and causes DNA breaks following free radical attack

DLT: pulmonary toxicity
IFN alpha
use: leukemia, sarcoma, squamous cell carcinoma
IL-2
use: renal cell carcinoma, malignant melanoma.

MOA: inc. activity of NK cells
hydroxyurea
misc. chemotherapeutic

MOA: inhibit ribonucleotide diphosphate reductase, blocking DNA synthesis

NDP's can't be turned into dNDPs....
prednisone
use: leukemia and lymphoma

inhibits T cell proliferation
tamoxifen
SERM
leuprolide
inhibits gonadotropin release, suppressing ovarian and testicular steroidogenesis (gonadotropin-releasing hormone analog)

use: hormone stimulated cancer
trastuzumab
breast cancer chemotherapeutic

inhibits HER2 overexpressing tumor cell proliferation through antibody-dependent cytotoxicity
imatinib
this is Gleevec!! (imagine gleevec)

inhibits TK activity of BCR-ABL

use:CML
herceptin
antibody

kills tumors expressing her2/neu (breast cancer)
celecoxib
apoptosis inducer
thalidomide
anti angiogenic compound