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21 Cards in this Set
- Front
- Back
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antimetabolites
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1. S phase specific
2. methotrexate and 5 fluoruracil |
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MT inhibitors
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1. M phase specific
2. vincristine/vinblastine 3. taxanes: paclitaxel, docetaxel 4. neuropathy |
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Topoisomerase Inhibitors
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1. S phase specific
2. etoposide, teniposide, topotecan, irinotecam 3. MDR1 resistance |
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DNA intercalating
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1. non specific
2. abx DNA strand breaks 3. dactinomycin, doxorubicin, bleomycin |
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methotrexate
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1. folic acid analog
2. decrease dihydrofolate reductase 3. C/I with probenacid |
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5-fluorouracil
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1. inhibit thymidilate synthase
2. inhibit uracil converted to thymidine 3. potent radiosensitizer |
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vincristine/vinblastine
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1. alkaloid blocks tubule polymerization
2. mitotic spindle cant form 3. MDR1 resistance |
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taxanes
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1. paclitaxel, docetaxel
2. block tubule depolymerization 3. MDR1 resistance |
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Dactinomycin
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1. intercalating
2. lymphatic atrophy 3. pediatric chemotherapeutic 4. vesicant that may cause tissue blistering and bleeding |
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doxorubicin
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1. intercalating
2. free radical cardiotoxicity, red urine 3. MDR1 |
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bleomycin
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1. intercalating
2. pulmonary fibrosis and rare fulminant liver fx 3. overall low SA |
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MDR1
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1. vincristine/vinblastine
2. taxanes 3. topoisomerase inhibitors 4. doxorubicin |
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alkylating agents
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1. Nitrogen mustard
2. nitrosureas 3. hydrazines 4. platinum |
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Nitrogen mustard
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1. cyclophosphamide
2. melphalan |
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Nitrosureas
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1. carmustine
2. lomustine 3. streptozotocin |
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Hydrazines
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1. procarbazine
2. decarbazine |
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Platinum
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1. cisplatin
2. carboplatin 3. ototoxicity, nausea, vomiting, peripheral neuropathy, nephrotoxicity |
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small molecule inhibitors
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1. vemurofenib: inhibit mutant B-raf kinase, double survival time
2. imatinib: inhibit bcr-abl kinase, CML and ALL |
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rationally designed chemo
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1. target causative: panitumumab (EGFr) and trastuzumab (HER2 and LT with doxorubicin)
2. target non-causative: rituximab (CD20 and tumor lysis syndrome=renal) |
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anti androgens
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1. cyproterone: steriodal block receptor binding
2. bicalutamide: non steriodal block AR translocatin |
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anti angiogenesis
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1. bevacizumab: Ab VEGF, prevent receptor binding
2. pazopanib: small molecule inhibitor of VEGF receptor |
