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26 Cards in this Set
- Front
- Back
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G1 Phase |
L-Asparaginase
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L-Asparaginase
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Deprives cells of asparagine-> inhibition of protein synthesis
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G2 Phase
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Bleomycin
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Bleomycin
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Complex undergoes oxidation-> generating superoxide andhydroxyl radicals -> DNA strand breaks
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M Phase
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PaclitaxelDocetaxelVinblastineVincristine
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PaclitaxelDocetaxel
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Hyperstabilizespolymerized microtubules-> anaphase cannot occur
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VinblastineVincristine
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Prevent microtubulepolymerization -> preventingmitotic spindle formation -> M-phasearrest
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S/G2 Phase
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Etoposide(Podophyllotoxins)
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Etoposide(Podophyllotoxins)
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Inhibits topoisomerase II-> ↑ DNA degredation
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Non-specific Cell Cycle
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Alkylating AgentsPlatinum ComplexesAntitumor Antibiotics
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Platinum Complexes
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CisplatinCarboplatinOxaliplatin
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CisplatinCarboplatinOxaliplatin
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Cross-linkDNA
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Antitumor Antibiotics
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Dactinomycin(Actinomycin D)Anthracyclins(-rubicins)
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Anthracyclins(-rubicins)
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-Intercalates in DNA ->breaks in DNA -> ↓ replication-Inhibition oftopoisomerase II-Generates free radicals
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Dactinomycin(Actinomycin D)
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-Intercalates betweenadjacent G-C pairs inDNA-Inhibition oftopoisomerase I-Generates free radicals
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Alkylating Agents
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CarmustineLomustineBusulfanCyclophosphamideIfosphamide Others:ProcarbazineTemozolamideMelphalanMechlorethamineChlorambucil
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CarmustineLomustine(Nitrosoureas)
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Requires bioactivation-> crosses blood-brain barrier-> cross links DNA
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Busulfan
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Cross-links DNA
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Cyclophosphamide Ifosphamide |
Covalently X-link (interstrand) DNA at guanine N-7. Require bioactivation by liver (CYP450)
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S Phase
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CytarabineMethotrexate6-Mercaptopurine6-ThioguanineIrinotecanTopotecan5-FUHydroxyurea
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6-Mercaptopurine6-Thioguanine
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Purine analog, causing decreased de novopruine synthesis
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IrinotecanTopotecan
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Topoisomerase I inhibition -> DNAstrand breaks
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5-FU
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Pyrimidine analog, activatedinto 5F-dUMP, which covalentlycomplexes folic acid ->thymidylate synthaseinhibition -> ↓dTMP -> ↓DNA and↓ protein synthesis.
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Hydroxyurea
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Inhibits ribonucleotide reductase -> ↓ DNA synthesis
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Methotrexate
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Folic acid analog that inhibitsdihydrofolate reductase -> ↓dTMP -> ↓DNA and↓ protein synthesis
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Cytarabine
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Pyrimidine analog, causingDNA polymerase inhibition
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