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13 Cards in this Set
- Front
- Back
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Modes of Action
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Either by directly killing microorganisms (bactericidal) or by inhibiting their growth (bacteriostatic)
Pcn- inhibit cell wall synthesis in bacteria. Other agents chloramphenicol, erythromycin, tetracyclines, and streptomycin, inhibit protein synthesis by acting on 70Sribosomes. Polymyxin b cause injury to plasma membranes. Rifampin and the quinolones inhibit nucleic acid synthesis. Agents such as sulfanilamide act as antimetabolites by competitively inhibiting enzyme activity. |
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Antiviral Agents
Amantadine- |
blocks the penetration or uncoatingof influenza A virus.
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Acyclovir-AZT, ddl and ddC
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Inhibit DNA or RNA synthesis
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Nevirapine(viral enzymes)
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inhibits reverse trnascriptase and protease inhibitors which block an HIV enzyme.
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Xenografts
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Subject to hyperacute rejection
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Alpha-interferons`
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Inhibit spread of viruses to new cells.
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Nystatin & amphotericin B
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combine with plasma membrane sterols are fungicidal
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Imadzoles&trizoles
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interfere with sterol synthesis and used to treat cutaneous and systemic mycoses.
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Griseofulvin
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interferes with eucaryotic cell division an dis used to treak skin infections caused by skin infedctions caused by fungi.
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Flucytosine
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Antimetabolite of Cytosine.
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Antiparsitic Agents
Chloroquine, quinacrine, dilodohdroxquin, pentamidine, metronidazole |
Used to treat aprotozoan infections.
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Niclosamide, mebendazole, praziquantel,piperazine
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Antihelminthic drugs
Mebendazole disrupts microtubules-pyantel pamoate, paralyzes intestinal roundworms. |
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Antibiotics- Pencillin and others
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Pencillin-effective against gram positive cocci & spirochetes.
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