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15 Cards in this Set
- Front
- Back
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List some aromatase inhibitors
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aminogluthimide, anastrozole, exemestane, letrozole
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What are SARMs? Mechanism of action?
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Block androgen receptor, prevent binding of testosterone.
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What are SARMs used for?
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Prostate CA
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List some SARMs
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cyproterone, flutamide, bicalutamide, nilutamide
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What are GnRH agonists? Mechanism of action?
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Initial stimulation, then inhibition of LH and FSH -> reduced androgen synthesis
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List some GnRH agonists
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Leuprolide, goserelin, tritorelin
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What is L-asparaginase?
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Many cancer cells don't make asparigine. This breaks down asperagine.
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What is L-asparaginase used for?
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ALL
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What are the SEs of L-asparaginase?
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Anaphylaxis
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Describe hydroxyurea
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Limits RNA reductase, limiting DNA synthesis. Also used for tx of vasospasm/occlusion in sickle cell
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Describe Arsenic Trioxide
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Unknown mech of action. Produces remission in acute premyelocytic leukemia who are unresponsive to other tx's.
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Describe mitoxantrone
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Binds to DNA, breaks strands. Most active in S phase. Used for leukemia and prostate.
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Describe mitotane
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DDT cogener used only for adrenal CA. Mech of action unknown.
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Describe protein tyrosine kinase inhibitors
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Block ATP binding to kinase, stopping differentiation/division signals. Stop proliferation, survival, invasion and angiogenesis. Name: *ib
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Describe Imatinib
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Inactivate kinase of BCR-ABL, the protein that causes CML
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