Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
List the vinca alkaloids
|
Vincristine [Oncovin, Vincasar], vinblatin [Velban]
|
|
|
List the plant alkaloids
|
*taxel: Paclitaxel [taxol], docetaxel
|
|
|
What are alkaloids used for?
|
Breast, bladder, testicular, non-small cell lung CA, leukemia, lymphoma
|
|
|
What is the mechanism of action of antibiotics?
|
Bind to DNA through intercalcation b/t bases, blocking synthesis of RNA or fragmenting DNA
|
|
|
What are antibiotics used for?
|
Testicular, breast, ovarian thyroid, pancreatic Ca, lymphosarcoma
|
|
|
What side effects does doxyrubicin have?
|
Cardiomyopathy [50% mortality w/ CHR]
|
|
|
What side effects does bleomycin have?
|
Pulmonary toxicity [5-10%], worse w/ high FiO2, large volume of crystaloids
|
|
|
What are general side effects of antibioics?
|
Cardiomylpathy, hepatic dysfunction
|
|
|
What are the antibiotics?
|
*rubicin, *myocin, *mycin
|
|
|
What are SERMs? What do they do?
|
SERMs modify the response of the estrogen receptor
|
|
|
What is the classic SERM? What is it used for?
|
Tamoxifen. Used for Breast Ca w/ + estrogen receptor and progestrerone receptor tumors.
|
|
|
What are the SEs of SERMs?
|
Menopausal sxs, menstraul irregularities, increased risk of blood clots, increased risk of endometrial cancer
|
|
|
What is fulvestrant?
|
A full ER antagonist [no agnosist] => downregulation of estrogen receptors
|
|
|
Describe the mechanism of action of aromatase inhibitors
|
Inhibit aromatase, which converts androgens to estrogens [in females]
|
|
|
What are aromatase inhibitors used for?
|
Tx of metastatic breast CA
|
