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15 Cards in this Set
- Front
- Back
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Describe carcinogenic changes in cell adhesion and motility
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1) no contact inhibition 2) alterations in adhesion allow cancer cells to migrate
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Describe changes in cell aging in cancer
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1) Limitless division w/out normal aging [d/t activation of telomerase]
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Describe chances in angiogenesis w/ cancer
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1) cancer cells produce factors that stimulate angiogenesis 2) naturally occuring inhibis of angiogenesis: thrombospondin, angiostatin and endostatin
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What is the only consistent curative approach for cancer?
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Surgery
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What is the first-line treatment for many solid cancers?
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Surgery
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Is single-drug chemotherapy effective?
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No
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For what purpose are chemo and radiation combined?
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eradication of residual microscopic disease, or paliative, symptom control
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How do hormonal treatments work?
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Prevent cancer cells from receiving signals necessary for continued growth
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How do antibodies work?
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Interfering w/ signaling or causing the direct death of cells [complement, etc.]
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How do BRMs work?
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stimulate the body's own response against cancer
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What is the overall cure rate for cancer?
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50%
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What % are cured with "local measures" [surgery, radiation]
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33%
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What % are cured with chemo [post surg/radiation]?
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17%
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What is the gompertzian growth curve?
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An S-shaped growth curve. Initially cell growth is limited, then accellarates. As it reaches the limits of detection, cell growth slows, usually d/t inadequate blood supply
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List some fast-growing tumors
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AML, lymphomas, Hodgkin's
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