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15 Cards in this Set
- Front
- Back
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cyclophophamide, ifosphamide, melphalan
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nitrogen mustard, alkylate DNA on bases, x-link, abnormal bp/breaks
myelosuppression hemorrhagic cystitis (prevent w/ mesna) MOPP marrow toxicity/myelodysplasia/ leukemia |
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carmustine, lomustine, semustine, streptozocin
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nitrosureas, alklate DNA base, x-link, abnormal bp, BDN break, CNS tox
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busulfan
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alkyl sulfonate, alylate nucleophilic grp on DNA, x-link, abnorm bp, DNA break, , pulm fibrosis, hyperpigment, gynecomastia
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cisplatin, carboplatin
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platinum analigues, alkylate grps on DNA, X-link, DNA break, nephro/ototox
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daunorubicin, doxorubicin
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anthracycline, topo II DNA stabilize and inhib DNA syn, breaks, A in ABVD
cardiotoxic |
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etoposide
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epipodophyllotoxin, G2-ph specific agent, inhib top II, inc DNA degrade, myelosuppress
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vinblastine/vincristine
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vinca alkaloids, antimicrotubule, inhib polymerization, O of MOPP
BLASTs bone marrow suppression peripheral neuropathy/ neurotoxicity |
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docetaxel, paclitaxel
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epothilones, antimicrotuble, myelosuppresion, admisiter before cisplatin
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MTX
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comp inhib folic acid --> THF, no purine, renal tubular necrosis (hydration needed), pulm pneumonitis, need to alkalinize to prevent crystals
use of leucovorin with methotrexate (rescue) vs 5 FU (potentiates) |
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6-MP
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analogue guanine, bone marrow suppression
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hydroxyurea
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inhob ribonucleotide reductase
bone marrow suppress |
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ara-C, 5-FU
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antimetab, pyrimidine analogues
myelosuppression |
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herceptin
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cardiotoxic
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imantinib (gleevec)
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tyrosine kinase
myelosuppression |
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bleomycin
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creates radicals that break DNA
interstitial pneumonitis/pulm fibrosis |
