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18 Cards in this Set
- Front
- Back
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What is the epidemiology of CLL...
How does it rank in leukemias? Demographics of men and women? Demographics of ethnicities? |
Most common leukemia
2x higher in men Higher incidence in European ancestry |
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What are two (2) main patient presentation points of CLL?
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Recurrent infections*
Hypogammaglobinemia* |
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CLL is predominantly a __-lymphocyte disorder
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B
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What are other minor patient presentation points of CLL?
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Lymphadenopathies
Splenomegaly Thrombocytopenia Hyperleukocytosis |
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What are two (2) poor prognostic genetic markers of CLL?
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CD38
ZAP70B |
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What are the two staging systems of CLL?
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Rai (progressive nature of disease)
Binet (number of sites and presence of blood dyscrasias) |
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Treating indolent disease improves outcome of CLL
(true/false) |
False - early treatment has no benefit
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What is the primary drug to focus on for CLL?
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Fludarabine*
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What are some toxicities associated with fludarabine in CLL?
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More opportunistic infections*
Myelosuppression, immunosuppression, neurotoxicity |
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What are the four (4) boxed warnings of rituximab?
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Infusion-related events (chimeric)
Tumor lysis syndrome Mucocutaneous reactions Positive Multifocal Leukoencephalopathy (PML) |
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Which drug is a humanized MAB against CD52 antigen used in CLL?
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Alemtuzumab (Campath)
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What are the mechanisms of action for alemtuzumab (Campath)?
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Lyses lymphocytes via complement fixation, antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis
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What are the toxicities associated with alemtuzumab (Campath)?
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Infusion-related events
Thrombocytopenia Neutropenia |
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Which CLL drugs can cause an increase in opportunistic infections as a side effect?
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Fludarabine*
Alemtuzumab (Campath) |
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What are the two (2) newer agents used in CLL?
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Bendamustine (Treanda)
Ofatumumab (Arzerra) |
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What is Bendamustine's (Treanda) mechanism of action?
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Alkylating agent (purine analog)
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What is Ofatumumab's (Arzerra) mechanism of action?
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Anti-CD20 agent
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What supportive care should be given in CLL for recurrent infections?
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Antimicrobials as appropriate
IVIG (because of hypogammablobulinemia) |
