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20 Cards in this Set
- Front
- Back
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To what class do nitrogen mustards belong and what agents are included?
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Alkylating agents
Mechlorethamine (Mustargen) Cyclophosphamide (Cytoxan, Neosar) Ifosfamide (Ifex) Melphalan (Alkeran) Chlorambucil (Leukeran) |
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To what class do ethylenimines and emthylmelamines belong and what agents are included?
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Alkylating Agents
Altretamine (Hexalen) Thiotepa (Thioplex) |
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To what class do alkyl sulfates belong and what agents are included?
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Alkylating Agents
Busulfan (Myleran, busulfex) |
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To what class do nitrosureas belong and what agents are included?
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Alkylating Agents
Carmustine (BCNU) Lomustine (CCNU) Streptozocin (Zanosar) Polifeprosan 20 with carmustine implant (Gliadel) |
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To what class do folic acid metabolites belong and what agents are included?
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Antimetabolites
Pemitrexed (Alimta) Methotrexate (Rheumatrex) |
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To what class do pyrimidine analogs belong and what agents are included?
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Antimetabolites
Azacitidine (Vidaza) Fluorouracil, 5-FU (Adrucil) Cytarabine (Cytosar-U, DepoCyt) Capecitabine (Xeloda) Gemcitabine (Gemzar) Decitabine (Dacogen) |
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To what class do purine analogs belong and what agents are included?
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Antimetabolites
Clofarabine (Clolar) Mercaptopurine (Purinethol) Thioguanine (Tabloid) Pentostatin (Nipent) Cladribine (Leustatin) Fludarabine (Fludara) |
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To what class do guanosine analogs belong and what agents are included?
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Antimetabolites
Nelarbine (Arranon) |
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To what class do antharacyclines belong and what agents are included?
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Antitumor antibiotics
Doxorubicin (Adriamycin, Doxil [liposomal]) Daunorubicin (Cerubidine, Daunoxome [liposomal]) Epirubicin (Ellence, Pharmarubicin) Idarubicin (Idamycin) Mitoxantrone (Novantrone) Valrubicin (Valstar) |
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To what class do alkylating-like agents belong and what agents are included?
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Antitumor antibiotics
Mitomycin (Mutamycin) |
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To what class do chromomycin agents belong and what agents are included?
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Antitumor antibiotics
Dactinomycin (Cosmegen) |
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What is a miscellaneous antitumor antibiotic?
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Bleomycin (Blenoxane)
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What is the regimen CHOP and what type of cancer is it used for?
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Cyclophosphamide
Hydroxy-danarubicin Oncovin (vincristine) Prednisone Used for non-Hodgkins lymphoma |
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What is the regimen ABVD and what type of cancer is it used for?
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Adriamycin
Bleomycin Vinblastine Dacarbazine Used for Hodgkins disease |
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What is the regimen CAF and what type of cancer is it used for?
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Cyclophosphamide
Adriamycin Fluorouracil Used for breast cancer |
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What is the regimen EP and what type of cancer is it used for?
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Etposide
Cisplatin Used for lung cancer |
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What is the regimen MAID and what type of cancer is it used for?
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Mesna, Adriamycin, Ifosfamide, Dacarbazine
Used for sarcoma |
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Which common chemo agents require a dosage modification in patients with renal dx?
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Bleomycin
Capecitabine Cisplatin Etoposide Methotrexate |
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Which common chemo agents require a dosage modification in patients with hepatic dx?
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Doxorubicin
Etoposide Vincristine Paclitaxel (Bilirubin is the major monitoring parameter) |
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List four common chemoprotectants and their uses
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Mesna (Mesnex) - protects against hemorrhagic cystitis caused by cyclophosphamide and ifosfamide. Mesna binds the destructive metabolite.
Dexrazoxane (Zinecard) - cardioprotectant from anthrocyclines (rubicins). Free oxygen radicals damage heart; this drug scavenges the radicals. Amifostine (Ethyol) - Prevents nephrotoxicity with cisplatin. Can cause HoTN and severe N/V. Also used for radiation SE. Leucovorin - methotrexate inhibits dihydrofolate reductase, leading to myelosuppression and mucositis. Leucovorin rescues normal cells. |
