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45 Cards in this Set

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  • Back
M phase specif agent that binds to tubulin and hyperstabilized polymerized microtubules
paclitaxel
taxols treat these 2 ca's
ovarian
breast ca
blasts BM
vinblastine
neurotoxic alkaloid
vincristine
m phase specific alkaloid that blocks polymerization of MT's so they can't form
vincristine and vinblastine
part of MOPP (lymphomas)
wilms' tumor
choriocarcinoma
vincristine and vinblastine
philadelphia chromosome bcr-abl tyrosine kinase inhibitor
imatinib (gleevac)
tx of CML and GI stromal tumors
imatinib (gleevac)
monoclonal ab against HER-2 (erb2)
herceptin (trastuzumab)
used for metastatic breast ca
herceptin/trastuzumab
receptor antagonist at breast; receptor agonist at bone
tamoxifen/raloxifen
breast ca and the prevention of osteoporosis
tamoxifen/raloxifen
increased risk with tamoxifen
endometrial carcinoma via partial agonist effects
part of MOPP regiment and an immunosuppressant with autoimmune disease
prednisone
toxicity of prednisone
cushing-like
immunosuppression
cataract
acne
osteoporosis
hypertension
peptic ulcer
hyperglycemia
psychosis
g2 and s phase specific agent that inhibits topoisomerase II and increases dna degradation
etoposide
side effects of myelosuppression, gi irritation, and alopecia
etoposide
uses of etoposide
small cell ca
testicular ca
pulmonary fibrosis with skin changes; minimal myelosuppression
bleomycin
part of ABVD regimen for hodgkin's
testicular ca
bleomycin
alkylating agent that forms free radicals that cause breaks in dna strands
bleomycin
alkylating agent for childhood tumors
dactinomycin
uses of dactinomycin
wilms' tumor
ewing's sarcome
rhabdomyosarcoma
treatment of doxorubicin toxicitiy
dezroxacine
ABVD regimen for hodgkin's
myeloma
sarcoma
solid tumors
adriamycin
alkylating agent that generates free radicals and noncovalently intercalates dna (creates breaks)
doxorubicin
alkylates DNA and tx of cml
busulfan
pulmonary fibrosis + hyperpigmentation
busulfan
acts like an alkylating agent with neurotoxicity
cisplatin
carboplatin
cisplatin/carboplatin
testicular ca
bladder ca
ovary
lung carcinomas
alkylating agents for brain tumors
nitrosureas -
carmustine
lomustine
semustine
streptozocin
alkylating agent that covalently x-links dna at guanine N-7
cyclophosphamide
hemorrhagic cystitis
cyclophosphamide
ifosfamide
prevention of hemorrhagic cystitis with cyclophosphamide
mesna
non-hodgkin's lymphoma, breast and ovary ca
cyclophosphamide/ifofsamide
antimetabolite inhibits dna polymeriase
cytarabine (ara-C)
blocks denovo purine synthesis
6 mp
metabolized by xanthine oxidase and activated by hgprtase
6mp
6mp txs?
leukemia, lymphomas
s phase antimetabolite that inhibits thymidylate synthase
5fu
5fu rescue
thymidine
5fu txs?
colon ca and other solid tumors
basal cell CA
synergistic with mtx
golic acid analog
methotrexate
uses of methotrexate
leukemia
lymphoma
choriocarcinoma
sarcoma
abortion
ectopic pregnancy
RA
psoriasis
myelosuppression rescue of mtx
leucovorin (folic acid)