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45 Cards in this Set
- Front
- Back
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M phase specif agent that binds to tubulin and hyperstabilized polymerized microtubules
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paclitaxel
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taxols treat these 2 ca's
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ovarian
breast ca |
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blasts BM
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vinblastine
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neurotoxic alkaloid
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vincristine
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m phase specific alkaloid that blocks polymerization of MT's so they can't form
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vincristine and vinblastine
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part of MOPP (lymphomas)
wilms' tumor choriocarcinoma |
vincristine and vinblastine
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philadelphia chromosome bcr-abl tyrosine kinase inhibitor
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imatinib (gleevac)
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tx of CML and GI stromal tumors
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imatinib (gleevac)
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monoclonal ab against HER-2 (erb2)
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herceptin (trastuzumab)
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used for metastatic breast ca
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herceptin/trastuzumab
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receptor antagonist at breast; receptor agonist at bone
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tamoxifen/raloxifen
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breast ca and the prevention of osteoporosis
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tamoxifen/raloxifen
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increased risk with tamoxifen
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endometrial carcinoma via partial agonist effects
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part of MOPP regiment and an immunosuppressant with autoimmune disease
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prednisone
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toxicity of prednisone
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cushing-like
immunosuppression cataract acne osteoporosis hypertension peptic ulcer hyperglycemia psychosis |
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g2 and s phase specific agent that inhibits topoisomerase II and increases dna degradation
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etoposide
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side effects of myelosuppression, gi irritation, and alopecia
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etoposide
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uses of etoposide
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small cell ca
testicular ca |
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pulmonary fibrosis with skin changes; minimal myelosuppression
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bleomycin
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part of ABVD regimen for hodgkin's
testicular ca |
bleomycin
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alkylating agent that forms free radicals that cause breaks in dna strands
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bleomycin
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alkylating agent for childhood tumors
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dactinomycin
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uses of dactinomycin
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wilms' tumor
ewing's sarcome rhabdomyosarcoma |
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treatment of doxorubicin toxicitiy
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dezroxacine
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ABVD regimen for hodgkin's
myeloma sarcoma solid tumors |
adriamycin
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alkylating agent that generates free radicals and noncovalently intercalates dna (creates breaks)
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doxorubicin
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alkylates DNA and tx of cml
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busulfan
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pulmonary fibrosis + hyperpigmentation
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busulfan
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acts like an alkylating agent with neurotoxicity
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cisplatin
carboplatin |
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cisplatin/carboplatin
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testicular ca
bladder ca ovary lung carcinomas |
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alkylating agents for brain tumors
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nitrosureas -
carmustine lomustine semustine streptozocin |
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alkylating agent that covalently x-links dna at guanine N-7
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cyclophosphamide
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hemorrhagic cystitis
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cyclophosphamide
ifosfamide |
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prevention of hemorrhagic cystitis with cyclophosphamide
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mesna
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non-hodgkin's lymphoma, breast and ovary ca
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cyclophosphamide/ifofsamide
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antimetabolite inhibits dna polymeriase
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cytarabine (ara-C)
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blocks denovo purine synthesis
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6 mp
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metabolized by xanthine oxidase and activated by hgprtase
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6mp
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6mp txs?
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leukemia, lymphomas
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s phase antimetabolite that inhibits thymidylate synthase
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5fu
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5fu rescue
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thymidine
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5fu txs?
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colon ca and other solid tumors
basal cell CA synergistic with mtx |
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golic acid analog
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methotrexate
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uses of methotrexate
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leukemia
lymphoma choriocarcinoma sarcoma abortion ectopic pregnancy RA psoriasis |
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myelosuppression rescue of mtx
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leucovorin (folic acid)
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