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22 Cards in this Set
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- Back
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antiemetics for high risk chemo
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5HT3
NK1 dexa +- ativan +- h2 or PPI |
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antiemetics for mod risk chemo
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5ht3
dexa +-ativan +- PPI or H2 with or without nk1 |
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low and minimal risk chemotherapy
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dexa, compazine, metoclopramide
+- ativan +- h2 or PPI |
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what is seen in tumor lysis syndrome?
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hyperkalmeia]hyperuircemia
high phos low ca acute renal failure! |
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dukes c cancer recommendation
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FU w/ leucovorin or capecitabine +-oxaliplatin (CAPEOX)
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mosiac trial recommendation
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folfox4 benfit stage III high risk 3 or more lymph nodes, T4 lesions
limit in stage 2 strongly consider oxaliplatin!!! |
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when do you use cetuximab in meta colonrectal cancer?
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irinotecan refactory regimens
with sometihng else or by its self not in KRAS mutations!!! |
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SCLC limited disease tx
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combo chemo and prop radiation of brain- maybe
chemo eto+ cisplatin eto+ carbo (if contra to cisplatin) more myelosupress |
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when do you consider prop brain xrt in SCLC?
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when they have had a complete response to chemo
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when do you use carbo instead of cisplati in extensive SCLC?
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>70 yo
preexisting condition myelosupression? hmm |
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extensive SCLC tx
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ep/ec
irino/cisplatin- japan study ep/cav |
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relapse of extensive SCLC <6 month tx?
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topotecan- 1st choice
CAV, gemcitibine, po eto, vinorelbine |
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stage 1 nsclc tx
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surgery+- chemo
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stage II NSCLC tx
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surgery, chemo +- radiation
chemo= cisplatin or carb/paciltaxel- if not tol cis |
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stage IIIa >2 ps and <2 ps NSCLC tx?
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<2= radio and chemo
>2= single chemo drug |
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cisplatin+ pemetrexed in NSCLC? when?
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non-squamous cell cancer only
EGFR mutation negative |
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bevacizumab in comba what NCSLC lst line?
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advanced NSCLC of nonsquamous histology
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not in combo with bevacizumab?
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gemcitabine/carbo
thromobocytopenia!!!!! |
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tx of recurrent or resistant NSCLC?
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docetaxel
pemetrexed- pleural effusions or renal insuff erlotinib- even high PS |
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low BRCA1 mRNA expression increased sensivity?
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increased sensitivity to cisplatin and etoposide
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low BRCA1 mRNA expression increased resisitance?
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paclitaxel and vincristine
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ribonucleotide reductase (RRM1)
low level high level |
low level= poor survival
high level= poor gemcitabine response |
