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30 Cards in this Set

  • Front
  • Back
What antimetabolite(s) has the greatest effect on cells in the S phase?
methotrexate and cytosine arabinose
What is the MOA of methotrexate?
a folic acid antagonist (competes for binding site on the enzyme dihydrofolate reductase preventing the synthesis of folate)
What is the antidote for cytotoxicity of methotrexate?
How does leucovorin provide it's antidote effect from methotrexate toxicity?
provides folate for cell
What drug(s)combination with methotrexate can lead to severe folate deficiency?
trimethoprim/sulfa antibiotic
What percentage of the dose of methotrexate is excreted in 24 hours and by what means?
90% of the dose is excreted in 24 hours and primarily excreted in the urine
What is the MOA of cytosine arabinoside?
inhibition of DNA polymerase
What is cytosine arabinoside used for the treatment of?
used to treat CNS lymphoma as well as in CSF, also used to treat leukemias
What antimetabolite do you never want to use in cats because of death?
(5FU), 5-Flurouracil
What is the mechanism of action of 5- flurouracil (5FU)?
it is a pyrimidine analog that exerts cytotoxic effects by inhibiting thymidylate synthetase; therefore inhibiting DNA synthesis and some RNA synthesis
What spp. of animal does 5FU normally cause neurotoxicity?
What reason do you use 5FU in large animals?
skin carcinomas and solar keratosis (2-4 month therapy)
What is the protocol for an accidental treatment of 5FU in cats?
there is nothing you can do, there is no taking back the administration
What are the platinum drugs?
Cisplatin and Carboplatin
What is the action of L-Asparginase?
enzyme cleaves extracellular pools of L-asparagine which is required by neoplastic lymphoid cells and is most effective in G1 phase
Why is folate important for the body?
Because it is needed for the production of purine nucleotides and thymidine
What is the mechanism of action for Cisplatin?
alkylation of DNA
What spp. do we never want to use cisplatin for?
How do you prevent nephrotoxicity in dogs when administering cisplatin?
pre hydrate the animal with saline to keep the kidney going
What side effects can be seen with Cisplatin treatment?
vomition, anorexia, and nausea
What drug(s) do you want to pretreat the animal with if Cisplatin must be administered?
butorphenol or ondansetron
What clinical signs may be seen with repeated doses of Cisplatin treatment?
hypomagnesemia, hypocalcemia, hyponatremia, hypokalemia, and hypophosphatemia
What drug is most similar to Cisplatin?
What kind of needles are forbidden when giving platinum drugs?
ammonium needles
What is the difference between Carboplatin and Cisplatin?
Carboplatin is safe to use in cats and is less renal toxic
What agents is not recommended to give with carboplatin and cisplatin?
How can cisplatin and carboplatin be administered?
In what conditions is L-Asparaginase used?
in lymphoid leukemia and lymphomia
What precaution is taken with administration of L-Asparaginase?
pretreat animal with diphenhydramine b/c this foregin protein can cause allergic reaction
What drug is given concurrently with piroxicam(non-steroidal antiinflammatory agent with antitumor activity) to prevent GI ulceration?