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15 Cards in this Set
- Front
- Back
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agonist
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a drug that has a strong affinity for a receptor and triggers the receptor when bound.
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antagonist
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a drug that has a strong affinity for a receptor and little or no intrinsic activity when bound.
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antimetabolite
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a drug that exerts its action against the normal metabolic processes of an organism, such as dna replication.
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drug
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a chemical introduced into a biological system that alters, inhibits, or supplements a biological process.
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enzyme
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a protein that performs chemical reactions, or assists in reactions, on other molecules
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inhibitor
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a drug that STOPS the functioning of an ENZYME or receptor.
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prodrug
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a substance that has no drug action until metabolizes.
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receptor
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a biological structure that, upon binding to substrate, releases a signal that starts a biological process.
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SAR
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structure-activity relationship
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suicide inhibitor
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a drug that inhibits a biological process by covalently bonding to an enzyme.
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transition state analog
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binds and blocks because it resembles transition state of reaction normally induced by enxyme, but is bound more strongly than natural substrate.
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sulfa drugs
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antiobiotics that inhibit enzyme necessary for folic acid synthesis (prevents bacterial growth).
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penicillins
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antibiotics that inhibit enzyme necessary for bacterial cell wall synthesis (suicide inhibitors).
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intercalation
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noncovalent insertion of drug molecule between dna base pairs. may lead to DNA damage or distorted structure.(ex: quinine)
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mutagen/carcinogen/teratogen
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causes dna mutations/causes cancer/causes fetal abnormalities
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