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7 Cards in this Set
- Front
- Back
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Hepatitis B virus (HBV)
[Transmission] [MOA] [Drugs] [Symptoms] |
[Transmission]—blood and semen
HBV vaccine [Drugs] Interferon alfa-2b [PEG-Intron] {MOA]: blocks viral machinery and entrance to new cells [Drugs] Interferon alfa-2b [PEG-Intron] Lamivudine [Epivir-HBV] antiviral Adefovir [Hepsera] antiviral [Symtoms] -Injection site interactions -Depression |
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Hepatitis C virus (HCV)
[Transmission] [Symptoms] [Drugs] [MOA] |
[Transmission]
blood and semen [Symptoms] No symptoms ****Leading reason for liver transplants***Know [Drug] Pegylated interferon alfa combined with Ribavirin- [MOA] -Not fully understood -Complicated |
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Acyclovir [Zovirax]/Valacyclovir(Valtrex)
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Valacyclovir is valine analogue of acyclovir
-Allows for 3 to 5 times greater bioavailability than oral acyclovir Purine nucleoside analogs -Suppress synthesis of viral DNA Blocks polymerase enzyme that builds DNA and is incorporated into viral DNA – Resistance-more common in allograft and HIV Uses: Herpes simplex viruses Varicella zoster virus Cytomegalovirus IV therapy: Phlebitis Reversible nephrotoxicity may be severe in large doses Oral therapy: Gastrointestinal-nausea and vomiting Vertigo Topical: Stinging sensations |
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Ganciclovir [Cytovene]
[USES] [SE] |
Use limited to immunocompromised
Synthetic antiviral agent Uses: -Herpes simplex viruses -Cytomegalovirus- CMV -Epstein-Barr virus-mononucleosis *aka Mono* Side effects: -Granulocytopenia -Thrombocytopenia |
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Interferon Alfa
[Type] [AE] |
Interferon family
Alfa, beta, gamma Adverse effects Flu-like symptoms -Acetaminophen Depression -SSRIs Injection site reactions -Cold compresses & NSAIDs |
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Drugs for Influenza
[Adamantanes] are? MOA:? AE:? |
Adamantanes:
-Amantadine [Symmetrel] -Rimantadine [Flumadine] MOA not fully understood, stops entrance of virus and affects replication. Adverse effects CNS-seizure, depression, hallucination |
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Drugs for Influenza:
Oseltamivir [Tamiflu] |
Inhibits neuraminidase, an enzyme known to cleave the budding viral progeny from its cellular envelope attachment point (neuraminic acid) just prior to release
Current drug of choice for avian and swine flu Must be use early in disease for maximum benefit ADR: Gastrointestinal: Vomiting (2% to 15%) Gastrointestinal: Nausea (3% to 10%), abdominal pain (2% to 5%) |
