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14 Cards in this Set
- Front
- Back
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Systemic Mycotic Infections Include?
[Opportunistic] [Nonopportunistic: |
[Opportunistic]
mucormycosis, aspergillosis, candidiasis,cryptococcosis, [Nonopportunistic:] sporotrichosis, blastomycosis, histoplasmosis, coccidioidomycosis |
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Superficial Mycotic Infections Include?
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Candidiasis
Dermatophytes |
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Amphotericin B
[Overview] [Uses] [AE] |
Broad spectrum antifungal agent
Highly toxic [Uses]: systemic mycoses [Adverse effects:] occur in all patients Infusion reactions Severe back pain, fever Nephrotoxicity Hypokalemia Hypotension Generalized muscle and joint pain |
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Explain "Amphoterrible" toxicity:
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Amphoterrible toxicity:
Binds to sterols in fungal cell wall Mammalian cells also have sterols, bacteria do not Binds to sterols, forms channels allowing cations to leak out Greater affinity for fungal sterols than mammalian Long course of therapy often months |
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Fluconazole [Diflucan]
[Overview] [SE] |
Azole group of antifungal agents
Lower toxicity level Uses: systemic mycoses Side effects: Cardiosuppression Liver damage GI effects |
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Azole Antifugal Mechanism
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Blocks fungal Cyp450 enzyme that is responsible for synthesis of ergosterol.
-Result is leaky membrane. -Generally well tolerated -Many, many drug interactions -Hepatotoxicity |
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Ketoconazole [Nizoral]
[Overview] [AE] |
Azole group of antifungal agents
Fungistatic Adverse effects: -Hepatotoxicity -Inhibits production of testosterone and estradiol -Gynacomastia, menstral irregularities -Abdominal pain, NV, HA |
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Griseofulvin
[Uses] [Action] [AE] |
[Uses]
-Superficial mycoses -Ineffective systemic mycoses [Action] -Inhibits fungal mitosis -**MUST be taken with fatty meal-ice cream. kids eat ice cream [Adverse effects] -Transient headache -Rash Gastrointestinal – Insomnia – Tiredness **Must be taken DAILY *** |
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Drugs-azole antifungals
[Topical [Oral] |
Clotrimazole—topical
Griseofulvin—oral |
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Tinea pedis?
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Athletes foot
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Tinea corporis
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-ringworm
-usually hygiene issue can use med from this on jock itch, but NOT other way around |
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Tinea cruris
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-jock itch
-usually hygiene issue -fungus usually caused from feet, from gym floor, to groin area -ask pt if they have athlethe foot, may have jock itch - |
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Tinea capitis
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-ringworm of scalp
-commonly seen in Infants |
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Griseoflulvin is commonly seen in who? Whats it due to?
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-In scalp of infants & toddlers
-due to immunodeficieny -difficult to treat -Must be applied daily, takes several weeks b/c has to break into layers of skin |
