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29 Cards in this Set
- Front
- Back
Which MHC class are CD4 T cells restricted to?
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MHC II
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True or false: yd(gamma delta) T cells are not MHC restricted?
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False, they may or may not be (trick question)
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Where does T cell development occur?
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Thymus
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What type of selection removes auto-reactive T cells?
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Negative selection
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Do yd-T cells undergo positive and negative selection?
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No
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What are immature T cells called?
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Thymocytes
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What happens in patients with DeGeorge's syndrome?
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Thymus fails to develop and T cells are absent.
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True or false: the thymus degenerates as we get older?
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True
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What receptor is required for T cell development?
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IL-7
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Which pathway results in a pre-TCR being made: alpha/beta or gamma/delta?
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Alpha/beta
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Which portion of the receptor is fully rearranged in the pre-TCR?
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Beta
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Is there a diversity region in the alpha chain?
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No
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How many times can a Beta chain rearrange to form a functional segment?
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Two
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Which segments rearrange first in a Beta chain?
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The D and J segments.
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What happens if you have no RAG genes?
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No B or T cells.
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What percent of double positive thymocytes are positively selected?
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Less than 2%
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What does it mean to be positively selected?
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If the double positive T cell can react with MHC molecules expressed on cells in the thymic cortex.
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What happens if a T cell is able to recognize either MHC 1 or 2?
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The maturation process continues
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If MHC is not recognized by a double positive T cell, what happens?
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Cell dies (apoptosis)
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What does it mean for a T cell to be "double positive"?
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It expresses both CD4 and CD8 cell surface receptors.
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What happens if you cant express MHC 1 molecules?
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You will not have any CD8 T cell in the periphery.
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True or false: Positive selection controls the selection of CD4 or CD8 co-receptor?
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True
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What is the purpose of negative selection?
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To remove auto-reactive T cells from the thymus. (Makes sure they cant bind very well to self peptides)
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What is the transcription factor that is responsible for expression of tissue specific proteins in the thymus?
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Autoimmune regulator (AIRE)
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Cytotoxic T cells are CD4 or CD8 T cells?
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CD8
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What type of immunity is associated with Th1 and which cell surface molecule (4 or 8) do they express?
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Cell-mediated immunity. CD4
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Regulatory T cells express which cell surface molecule?
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CD4
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What can regulatory T cells do?
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Suppress proliferation of naive self-reactive T cells.
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What molecule is expressed on both alpha/beta and gamma/delta T cells?
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CD3
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