Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
Which MHC class are CD4 T cells restricted to?
|
MHC II
|
|
|
True or false: yd(gamma delta) T cells are not MHC restricted?
|
False, they may or may not be (trick question)
|
|
|
Where does T cell development occur?
|
Thymus
|
|
|
What type of selection removes auto-reactive T cells?
|
Negative selection
|
|
|
Do yd-T cells undergo positive and negative selection?
|
No
|
|
|
What are immature T cells called?
|
Thymocytes
|
|
|
What happens in patients with DeGeorge's syndrome?
|
Thymus fails to develop and T cells are absent.
|
|
|
True or false: the thymus degenerates as we get older?
|
True
|
|
|
What receptor is required for T cell development?
|
IL-7
|
|
|
Which pathway results in a pre-TCR being made: alpha/beta or gamma/delta?
|
Alpha/beta
|
|
|
Which portion of the receptor is fully rearranged in the pre-TCR?
|
Beta
|
|
|
Is there a diversity region in the alpha chain?
|
No
|
|
|
How many times can a Beta chain rearrange to form a functional segment?
|
Two
|
|
|
Which segments rearrange first in a Beta chain?
|
The D and J segments.
|
|
|
What happens if you have no RAG genes?
|
No B or T cells.
|
|
|
What percent of double positive thymocytes are positively selected?
|
Less than 2%
|
|
|
What does it mean to be positively selected?
|
If the double positive T cell can react with MHC molecules expressed on cells in the thymic cortex.
|
|
|
What happens if a T cell is able to recognize either MHC 1 or 2?
|
The maturation process continues
|
|
|
If MHC is not recognized by a double positive T cell, what happens?
|
Cell dies (apoptosis)
|
|
|
What does it mean for a T cell to be "double positive"?
|
It expresses both CD4 and CD8 cell surface receptors.
|
|
|
What happens if you cant express MHC 1 molecules?
|
You will not have any CD8 T cell in the periphery.
|
|
|
True or false: Positive selection controls the selection of CD4 or CD8 co-receptor?
|
True
|
|
|
What is the purpose of negative selection?
|
To remove auto-reactive T cells from the thymus. (Makes sure they cant bind very well to self peptides)
|
|
|
What is the transcription factor that is responsible for expression of tissue specific proteins in the thymus?
|
Autoimmune regulator (AIRE)
|
|
|
Cytotoxic T cells are CD4 or CD8 T cells?
|
CD8
|
|
|
What type of immunity is associated with Th1 and which cell surface molecule (4 or 8) do they express?
|
Cell-mediated immunity. CD4
|
|
|
Regulatory T cells express which cell surface molecule?
|
CD4
|
|
|
What can regulatory T cells do?
|
Suppress proliferation of naive self-reactive T cells.
|
|
|
What molecule is expressed on both alpha/beta and gamma/delta T cells?
|
CD3
|
