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75 Cards in this Set
- Front
- Back
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The morphologic classification of anemia is based on the |
Red blood cell indices |
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What are the symptoms specific for IDA |
Koilonychia Cheilitis pica
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Which laboratory test would be abnormal through each stage of iron deficiency |
Serum ferritin |
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A patient presents with a mcirocytic hypochromic anemia with ragged looking red blood cells in the peripheral smear and a high retic count. A brilliant cresyl blue preparation reveals inclusions that look like pitted golf balls. These inclusion are suggestive of |
Hgb H disease |
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The most cost effective therapy for a patient with hereditary hemochromatosis is |
Therapeutic phlebotomy |
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Two sets of laboratory data that can distinguish IDA from beta thalassemia trait |
Serum iron and RBC |
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What is the majority hemoglobin in thalassemia major |
Hgb F |
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Of the four clinical states of alpha thalassemia, which is incompatible with life |
Bart's hydrops fetalis |
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Which of the following hemoglobins has the chemical confirmation B4 |
Hgb H |
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Although there are many complication in individuals with thalassemia major which of the following is the leading cause of death |
Cardiac complications |
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Which bone marrow changes are most prominent in the megaloblastic anemias |
Asynchrony in the red blood cell precursors |
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Which morphologic changes in the peripheral smear are markers for megaloblastic anemias |
Oval macrocytes and hypersegmented neutrophils |
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Which is the most common vitamin deficiency in the United States |
Folic acid |
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Which of the following group of symptoms is particular to patients with megaloblastic anemia |
Difficulty in walking and mental confusion |
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Which one of the following substances is necessary for vitamin B12 to be absorbed |
Intrinsic factor |
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Which of the following clinical findings is indicative of intramedullary hemolysis |
Increased LDH |
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Which of the following adequately describes the pathophysiology of the megaloblastic anemias |
Lack of DNA synthesis |
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Which of the following morphologic features is classic in the megaloblastic red cell precursors |
Asynchrony |
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A macrocytosis that is not megaloblastic in origin cal be seen in all the following |
Chemotherapy Postsplenectomy Reticulocytosis |
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Ineffective erythropoeisis is defined as |
premature destruction of red blood cell precursors |
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The primary lymphoid organs are the |
Bone marrow and thymus |
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Which one of the following features distinguishes a monocyte from a lymphocyte |
Abundant gray blue cytoplasm |
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In which stage of neutrophilic maturation are specific secondary granules first seen |
Myelocyte |
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Which CD marker is specific for monocytes |
CD14 |
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Which subpopulation of T cells alters the cell membrane |
T cytotoxic |
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Lymphocyte concentrations in peripheral blood are greatest during what age interval |
Immediately after birth |
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The marginating pool of neutrophils is located |
on the blood vessels walls |
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Which of the following CD markers is more appropriately associated with the myelocyte |
CD45 CD33 CD13 |
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One of the primary glands in an infant responsible for lymphocyte origination is the |
Thymus gland |
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Individuals with iron deficiency have decreased |
Serum iron serum ferritin |
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Individuals with iron deficiency have increased |
TIBC |
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The anemia of chronic disease or the anemia of inflammation is one of the most common anemias in the _________ ________ |
hospital population |
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What is an inherited iron loading anemia called |
HH |
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Why are organs affected in HH |
because individual with HH have been iron loading for decades |
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Are serum iron and serum ferritin High or Low in HH |
High |
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What is the therapy of choice for HH |
Therapeutic phlebotomy |
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What is thalassemia syndrome |
goblin chain synthetic defects |
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How many clinical conditions of alpha thalassemia are there and how are they caused |
4 gene deletion |
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Beta thalassemia major is the most _________ of the beta thalassemic conditions |
severe |
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What are the symptoms of beta thalassemia major |
Severe anemia splenomegaly thalassemic facies |
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The majority hemoglobin in beta thalassemic major is |
Hgb F |
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Thalassemic minor is similar to IDA with the exception of |
Elevated RBC and an elevated Hgb A2 |
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The myeloid:erythroid (m:e) in the bone marrow is |
3 to 4:1 |
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Segmented neutrophils are held int he marginating pool for _____________ days before release to circulation |
7 to 10 |
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The maturation sequence for neutrophils for least mature to most mature |
Myeloblast promyelocyte myelocyte metamyelocyte band segmented |
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Cell id is based on |
cell size N:C ratio presences or lack of granules absence of nucleoli chromatin pattern texture of cytoplasm |
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The marginating pool designates white blood cells located along the |
vessel endothelium |
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The circulating pool designates white blood cells present in the |
blood stream |
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Lymphocytes originate not only from the _________ but also from the ___________ and _________ |
bone marrow Thymus gland lymphatic system |
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Primary lymphoid organs |
bone marrow and thymus |
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Secondary lymphoid organs |
spleen lymph nodes Peyer's patch tonsils |
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The lymphatic system plays an important role in |
blood filtration fluid balance antibody generation lymphopoiesis |
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T cells represent _________% of the total lymphocyte count |
60 - 80 |
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B cells represent _________% of the total lymphocyte count |
10 - 20 |
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T helper and T cyotoxic (suppressor cells) are essential in |
cell mediated immunity |
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What is derived from the total WBC's multiplied by the relative percentage of a particular WBC in the differential |
Absolute count
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Macrocytic anemia has MCV of ______________ and __________ MCHC |
greater than 100 normal |
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Megaloblastic anemias are macrocytic anemia in which ________ or _______ or both are deficient |
V b12
folic acid |
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True or False All macrocytic anemias are megaloblastic |
False |
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True or False Vitamin b12 and folic acid deficiencies led to impaired DNA synthesis |
True |
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The bone marrow in megaloblastic anemias is hyper-cellular with the red blood cells precursors showing |
distinct chromatin and cytoplasmic changes |
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Megaloblastic anemias show ineffective erythropoiesis in the bone marrow |
premature destruction of red blood cells precursors before delivery into the circulation |
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The peripheral smear in megaloblastic anemia shows |
macrocytes oval macrocytes hyper segmented neutrophils |
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Pancytopenia and reticulocytopenia are prominent features of the |
megaloblastic processes |
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Patients with megaloblastic anemia may exhibit symptoms |
anemia neurologic symptoms gastrointestinal symptoms psychological symptoms |
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Why are many elderly individuals not diagnosed with V b12 deficiency |
their symptoms are assumed to be related to other illnesses |
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Intrinsic factor which is secreted by the parietal cells of the stomach is necessary for |
V b12 absorption |
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Intrinsic factor deficiency may develop because intrinsic factor |
is not being secreted or because it is being blocked or neutralized |
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Of individuals experiencing pernicious anemia ________% have parietal cell antibodies |
90 |
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What is the most common vitamin deficiency in the United States |
Folic acid |
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Serum V b12, folic acid, red blood cell folate can be determined by |
radioimmunoassay |
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Individuals with V b12 deficiency require |
lifelong treatment |
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Folic acid deficiency requires ________ therapy |
short term |
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Serum MMA and homcysteine are sensitive indicator tests of mild _________ deficiency |
V b12 |
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Macrocutes may be seen in |
reticulocytosis alcoholic liver disease
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