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20 Cards in this Set
- Front
- Back
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Arachinonic acid is converted to good "housekeeping" prostaglandins that promote normal cellular responses by _____________ , while the prostaglandins that are responsible for inflammation are converted from arachidonic acid by _______________________. |
COX1, COX2 |
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What are the uses of prostaglandins (5) |
Tx pulmonary hypertension Induce childbirth/contractiosn Prevent closure of PDA Prevent peptic ulcers Tx Glaucoma/Ocular HTN |
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Misoprostol (Cytotec) |
PGE Analog to treat peptic ulcer by increasing mucus production and decreasing gastric acid secretion. |
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Illoprost (Ventavis) |
PGI Analog that when inhaled is a potent pulm vasodilator used to tx pulm hypertension |
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Alprostadil |
PGE analog used to keep PDA open |
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Latanopros (Xalatan) Bimatoprost (Lumigan) |
Reduce elevated intraocular pressure in patients with open angle glaucoma or ocular htn. |
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Aspirin |
Nonselective COx 1 and 2 inhibitor |
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Ibuprofen |
Nonselective COx 1 and 2 inhibitor |
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Naproxen |
Nonselective COx 1 and 2 inhibitor |
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Ficlofenac |
Nonselective COx 1 and 2 inhibitor |
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Ketorolac |
Nonselective COx 1 and 2 inhibitor |
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Celecoxib (Celebrex) |
Selective Cox 2 inhibitor |
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Remember question question 30, about rheumotoid arthritis |
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Gout is associated with high levels of? |
Uric Acid |
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Allopurinol |
Xanthine oxidase inhibitor Prevents gouty attacks |
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Febouxostat (Uloric)
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Xanthine oxidase inhibitorPrevents gouty attacks |
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Probenecid |
Increases uric acid excretion in the kidney |
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Colchicine |
Reduces inflammatory response associated with gout, and is used more for treatment and relief of pain in acute gouty attack . |
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What is the MOA for Triptan drugs |
Agonistic effects on central serotonin receptors in cranial blood vessels which cause their constriction Influence on trigeminal nerve endings which causes ihibition of pro-inflammatory and pain transmitter release. Work in 70-80% of patient to abort attack within 30-90 minutes. |
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Imitrex Maxalt Zomig |
Triptan drugs for migraine. |
