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38 Cards in this Set

  • Front
  • Back

Bioenergetics

Transfer of energy from foodstuffs into biologically usable form



Energy transfer in the cell occurs as a result of chemical reactions



Oxidation

The process of removing an electron from an atom or molecule



Molecule can't be oxidized unless it donates electrons to another atoms



Oxygen tends to accept electrons and is an important property used by cells to produce a usable form of energy

NAD AND FAD

vitamin b3


Vitamin riboflavin b2



Nad+= oxidized form

Enzymes



How do they lower activation energy?

Regulate the rate of speed at which the reaction takes place



By forming an enzyme -substrate complex



Name factors that alter enzyme activity

: temperature- have an optimum temperature at which they are active. When temperature increases so does the activity of enzymes, but an increase or decrease from the optimal temperature results in disassociate of the enzyme



2. Similar to ph. I.g accumulated hydrogen ions produced during heavy exercise decreases pH , therefore reducing enzyme activity

Carbohydrates fuel for exercise. What are they composed of?


What are their forms?


Carbon, hydrogen, and oxygen



Monosaccharides


Disaccharides, and polysaccharides



Cells store glycogen, because if there was individual glucose molecules inside cells osmotic pressure between the inside of cell and outside fluid would change causing more water to come into cell

Fats

Have a higher ratio of carbon to oxygen. Contain large quantities of energy per unit of weight



Four groups of fats

Fatty acids---primary type of fat used by muscle cells for energy



Triglycerides


Phospholipids


Steroids

High energy phosphates


ATP


name the 3 parts:

Adenine portion


Ribosome portion


3 linked phosphates

Bioenergetics: muscle cells produce ATP three ways

Formation of ATP by PC breakdown



Degradation of glucose or glycogen



Oxidative formation of ATP

PC to ADP forms ATP by:

Donating phosphocreatine's phosphate group to ADP( aDiphosphate = 2 phosphates)

Glycolysis

Breakdown of glucose or glycogen to form two molecules of pyruvate or lactate



Occurs in the sarcoplasm of the muscle cells

NAD+

Transport hydrogen


In order for glycolysis to continue , two hydrogens must be removed from g3p and combines with inorganic phosphate to form 1,3 bpg. The hydrogen acceptor is NAD+.

How is NAD+ reformed from NADH?

If enough oxygen is available, the hydrogen from NADH can be shuttled into the mitochondria of the cell contributing to ATP production. 2. Pyruvate can accept the h+ to form lactate if there is no oxygen available to accept them

Citric acid cycle-- Krebs cycle. What's the purpose of this cycle?

Complete the oxidation of acetyl CoA using NAD+ and FAD as electron carriers



The electron energy can be used in the ETC chain to combine AD + P to reform ATP

GTP

Formed in the citric acid cycle





Energy rich compound that can transfer its terminal phosphate group to ADP TO FORM Atp



Small amount

How do fats and proteins undergo aerobic metabolism?

Fats ( Triglycerides) are broken down to form fatty acids and glycerol.


They undergo beta-oxidation to form acetyl coA and thus enter the citric acid cycle

ETC chain

Occurs in the mitochondria


Cytoxhrome chain


Electrons removed from hydrogen atoms carried by transporter molecules are passed down the chain and energy is released to reform ATP

Why is oxygen necessary for the aerobic production of ATP?

Allows the etc chain to continue working because of its ability to oxidize the last cytochrome in the chain.

Products of glycolysis

2 ATP


2 NADH

Products of Krebs cycle

2 GTP


6 NADH


2 FADH

Rate limiting enzymes

They determine the speed of the particular metabolic pathway involved





Allosteric enzymes

Enzymes regulated by modulators



Control of ATP-PC system


"Negative feedback system"

Phosphocreatine breakdown is regulated by creatine kinase



Activated when there is an increase of ADP



TRIGGERS THE breakdown of PC to resynthesize ATP



Primary role of the Krebs cycle

Complete oxidation of substrates NADH and FADH to enter the ETC. the end result of the ETC Is the formation of ATP and water

Oxidation reduction reactions in cells often involve the transfer of ----- -‐---- ( with their electrons) rather than free electrons alone

Hydrogen atoms

Enzyme substrate

The shape of the enzymes active site must always fit for the binding substrates

List the four elements that make up 95% of the body

Oxygen


Carbon


Hydrogen


Nitrogen

Total of all cellular reactions and in ludes chemical pathways that result in the synthesis of molecules as well as the breakdown of molecules

Metabolism

Glycogenolysis

During exercise, individual muscle cells break down glycogen into glucose

T/f. Stored body fat is an ideal fuel for prolonged exercise because fat molecules contain large amounts of energy per unit of weight

True

ATPase

The enzyme that breaks the bond of ATP

The biochemical pathways that result in the production of ATP are regulated by precise control systems

Each pathway contains a number of reactions that are catalyzed by specific enzymes. If ample substrate ( fats, carbohydrates. Proteins) is available, an increase in the number of enzymes present results in an increased rate of chemical reactions

Rate limiting enzyme in glycolysis pathway

Phosphofructokinase

Phosphorylase

Enzyme that degrades glycogen to glucose. Important for providing the glycolytic pathway with the necessary glucose at the origin of the pathway

Calcium importance:

Each muscle contraction releases Ca+ is released from the sarcoplamic reticulum in the muscle. This indirectly activates enzymes to break down glycogen to glucose

Isocitrate dehydrogenase

Rate limiting enzyme in the citric acid cycle, inhibited by ATP and stimulated by high levels of ADP + Pi

High levels of ATP inhibit further ATP production, and high levels of ADP +Pi stimulate ATP production

True