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7 Cards in this Set
- Front
- Back
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Thrombolytic Drugs |
-drugs that break down, or lyse, preformed clots
-Older drugs *streptokinase and urokinase -Newer Drugs *Tissue plasminogen activator (t-PA) *Anisoylated plasminogen-streptokinase activator complex (APSAC) |
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thrombolytic Drugs: Mechanism of Action |
-activate the fibrinolytic system to break down the clot in the blood vessel quickly
-activate plasminogen and convert it to plasmin, which can digest fibrin
-reestablish blood flow to the heart muscle via coronary arteries, preventing tissue destruction |
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Thrombolytic Drugs: Indications |
the purpose of all thrombolytic drugs is to activate the conversion of plasminogen to plasmin, the enzyme that breaks down a thrombus
-acute MI -arterial thrombosis -DVT -occlusion of shunts or catheters -pulmonary embolism -acute ischemic stroke |
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Thrombolytic Drugs |
End in "plase" or "ase" |
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thrombolytic Drugs: Adverse Effects |
*Bleeding -internal -intracranial -superficial
*Other effects -hypersensitivity -anaphylactoid reactions -nausea -vomiting -hypotension |
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thrombolytic Drugs: toxicity and management of overdose |
treatment is symptomatic and supportive, because thrombolytic drugs have a relatively short half-life and no specific antidotes |
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thrombolytic drugs: Interactions |
increased bleeding tendency resulting from the concurrent use of anticoagulant, antiplatelets, or other drugs that affect platelet function |
