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596 Cards in this Set
- Front
- Back
How much fluid does the kidneys filter?
|
about 2000 liters
|
|
NAME
these filter about 2000 liters of fluid |
kidneys
|
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What are some exretory functions of the kidneys? (2)
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(1)reg the volume and chemical make up of the blood (2)maitaining the proper balance btwn water and salts btwn acids and bases
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|
NAME
these regulate the vol and chemical make up of the blood and maintaing the proper balance btwn water and salts btwn acids and bases |
excretory functions
|
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What are some functions of the kidneys other than exretory functions? (3)
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(1)Gluconegoensesis (2)producing the enzyme renin and erythropoietin(3)metabolizing vitamin D to its active form
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NAME
some of its functions include gluconeogenoesis, producing the enyzme renin and erythropoietin, and metabolizing vitamin D to its active form |
kidneys
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What is renin?
|
helps to regulate blood pressure and kidney function
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NAME
this helps to regulate blood pressure and kidney function |
renin
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What is erythropoietin?
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this stimulates red blood cells production
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NAME
this stimulats the red blood cells prodcution |
erythropoeitin
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What are the organs of the urinary system? (4)
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(1)kidneys (2)urinary bladder (3)ureters (4)urethra
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NAME
this includes the kidneys, urinary bladder, ureters, and urethra |
urinary system
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What is the urinary bladder?
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a temporary storage reservoir for urine
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NAME
this is a temporary storge reservoir for urine |
urinary bladder
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What is the ureters?
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are two tubelike organs
|
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What is the three tublike organs that make up the urinary system? (3)
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(1)paired urters (2)urethra
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NAME
these include the paired urters and urethra |
three tubelike oragns of the urinary system
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NAME
all of these furnish transportation channels for urine |
the paired urters (2)urethra
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What are the kidneys shaped like?
|
beans
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NAME
these are bean shaped |
kidneys
|
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Where are the kidneys located?
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the lumbar region from T12 to L3
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NAME
this organ is found in the lumbar region from T12 to L3 |
kidneys
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Which kidney is crowded by the liver and lies lower than the left?
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the right
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Where is the right kidney located compared to the left?
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the right kidney is crowded by the liver and lies lower than the left
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NAME
this kidney is crowded by the liver and lies lower than the left |
right kidney
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What is the renal hilus?
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is a vertical cleft that leads into the reneal sinus
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NAME
this is a vertical cleft that leads into the reneal sinus |
renal hilus
|
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What is the reneal sinus?
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is an internal space w/in the kidneys
|
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NAME
is an internal space w/in the kidneys |
reneal sinus
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NAME
atop of each of these are the adrenal glands |
kidneys
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Atop each kidneys is a (1)
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adrenal gland
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ATop each of (1)there is a adrenal gland
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kidneys
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What are three supportive tissue layers that surround kidneys? (3)
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(1)renal capsule (2)adipose capsule (3)renal fascia
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NAME
this has three supportive tissue layers that surround it: renal capsule, adipose capsule, and renal fascia |
kidneys
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What is the renal capsule?
|
is a fibrous transparent capsule that prevents infections in surrounding regions from spreading the kidneys
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NAME
this is a fibrous transparent capsule that prevents infection in surrounding regions from spreading the kidneys |
renal capsule
|
|
What is the adipose capsule?
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is fatty mass that attaches the kidney to the posterior body wall and cushions it against blows
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NAME
this is a fatty mass that attaches the kidney to the posterior body wall and cushions it against blows |
adipose capsule
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|
What is renal fascia?
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is an outer layer of the dense fibrous connective tissue that anchors the kidneys and the adrenal gland to the surrounding structures
|
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NAME
this an a outer layer of the dense fibrous connective tissue that anchors the kidneys and the adrenal gland to the surrounding structures |
renal fascia
|
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What is the adipose capsule important for kidneys?
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bc it holds the kidneys in thier normal position
|
|
the (1)of the kidneys is important in holding the kidneys in thier normal body postition
|
fatty encasement
|
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What is renalptosis?
|
refers to when the amount of fatty tissue dwindles causing one or both kidneys to drop to a lower position
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NAME
this refers to when the amount of fatty tissue dwindles causing one or both kidneys to drop to a lower postion |
renalptosis
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Renal ptosis may cause (1)
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a urter to become kinked, which creates a problem bc the urine, unable to drain, backs up into the kidneys and exerts pressure on its tissue
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NAME
this can cause a urter to become kinked, which creates a problem bc the urine, unable to drain, backs up into the kidneys and exerts pressure on the tissue |
renal ptosis
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What is hydronephrosis?
|
is the backup up of urine from ureteral obstruction or other causes
|
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NAME
this refers to the backup of urine from uretral obstructions or other causes |
hydronephrosis
|
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What are (3) distinct regions of the kidney?
|
(1)cortex (2)medulla (3)pelvis
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NAME
this has three distinct regions of the kidney cortex, medulla, and the pelvis |
kidneys
|
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What is the renal cortex?
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is the most superficial region, light in color and has a granular appearnance
|
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NAME
this is the most supericial region, light in color, and has a granular appearance |
the renal cortex
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What is the renal medulla?
|
is deep to the cortex, a darker reddish brown color, and has tissue masses called the medullary
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NAME
this is deep the the renal cortex, a darker reddish brown color, and has tissue masses called the medullary |
renal medulla
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the (1) is also called the renal pyramids
|
medullary
|
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the medullary is also called the (1)
|
renal pyramids
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What are renal columns?
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separate the renal pyramids
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NAME
these separate the renal pyramids |
renal columns
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What is the renal pelvis?
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is a flat funnel shaped tube, that is continous w/ the ureter leaving the ureter leaving the hilus
|
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NAME
is a flat funnel shaped tube that is continous w/ the ureter leaving the hilus |
renal plevis
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NAME
these collect urine from the papillae and empty it into the renal pelvis. the urine flows through the renal pelvis into the ureter, which transports it to the bladder, to be stored |
calyces
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Calyces collect urine from the (2) and empty it into the renal pelvis. The urine then flows through the renal pelvis into the ureter, which transports it to the bladder to be stored
|
papillae
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Calyces collect urine from the papillae and empty it into the (1). The urine then flows through the (1)into the ureter, which transports it to the bladder to be stored
|
renal pelvis
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Calyces collect urine from the papillae and empty it into the renal pelvis. the urine then flows through the renal pelvis into the (1),which transports it to the bladder to be stored
|
ureter
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Calyces collect urine from the papillae and empty it into then renal pelvis. The urine then flows through the renal pelvis into the ureter, which transports it into the (1) to be stored
|
bladder
|
|
What is the pvelitis?
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is a infection of the renal pelvis and calyces
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NAME
this is a infection of the renal pelvis and the calyces |
pevlitis
|
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What are pyelonephrisits?
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refers to infections or inflammations that affect the entire the kidneys
|
|
NAME
this refers to infection or inflammations that affect the entire kidneys |
pyelonephrisits
|
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What are urinary infections caused by females?
|
fecal bacteria
|
|
T or F
some urinary infections can be caused from bloodborne bacteria that lodge and multoply in the kidneys |
true
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|
T or F
the kidneys continously cleanse the blood and adjust its composition |
true
|
|
NAME
these continously cleanse the blood and adjust it composition |
kidneys
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Under normal resting conditions, the (1)deliver one fourth of the total cardiac output to the kidneys each min
|
renal arteries
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Under (1), the renal arteries deliver one fourth of the total cardaic output to the kidney each min
|
normal resting conditions
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What are the renal arteries?
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under normal resting conditions, the renal arteries deliver one fourth of the total cardiac output to the kidneys for each min
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NAME
under normal conidtions, these deliver one fourth of the total cardiac output to the kidneys per min |
renal arteries
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What happens as the renal arteries approach the kidneys?
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they are divided into five segmental arteries
|
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NAME
as the this appoarches the kidneys, it is divided into the five segmental arteries |
renal arteries
|
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What happens to the segmental arteries in the renal sinus?
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each segmental atry branches into several lober arteries which then divide into several lobar arteries
|
|
NAME
this branches into several lober arteries which then divide into several lobar arteries |
segmental arteries
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|
Draw a chart of the blood flow of the renal arteries to the renal cortex
|
See p 1000 or notepad
|
|
What happens to the interlobar arteries at the medulla cortex junction?
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the interlobar arteries branch into the arcuate arteries that arch over the branches of the medullry pyramids
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NAME
At the medullar cortex junction, these branch into the arcuate arteries that arch over the branches of the medullary pyramids |
the interlobar arteries
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More than 90% of the blood entering the kidney perfuses the (1)
|
renal cortex
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More than (1)of the blood entering the kidney perfuses the renal cortex
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90%
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Describe the blood flow from the veins starting w the renal cortex(HINT: is backwards of the arteries) (4)
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Blood leaves the renal cortex goes to the (1)interlobaular (2)arcuate (3)interlobar and then (4)the renal viens
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|
What is the renal plexus?
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is a variable network of automatic nerve fibers, ganglia, and provides the nerve supply of the kidneys and the ureter
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NAME
this provides the nerve supply of the kidneys and the ureter |
renal plexus
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|
What are nephrons?
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are the structural and functional units of the kidneys
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|
NAME
these are the structural and functional units of the kidneys |
nephrons
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What are collecting ducts?
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these collect urine from several nephrons and conveys it to the renal plevis
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NAME
these collect urine from the several nephrons and conveys it to the renal plevis |
collecting ducts
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What does each nephron consist of?
|
glomerulus
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NAME
each of these consist of a glomerulus |
nephron
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What is the glomerulus?
|
is a tough of capillaries associated w a renal tubule
|
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NAME
this is a tuft of renal capillaries associated w a renal tubule |
glomerulus
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|
what is the glomerular capsule?
|
is the cup shaped end of the renal tubule that completely surrounds the glomerulus
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NAME
this is the cup shaped end of the renal tubule that completely surrounds the glomerulus |
glomerular capsule
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the glomerular capsule can also be called the (1)
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Bowman's capsule
|
|
What is the renal corpuslce?
|
refers to the glomerular capsule and the enclosed glomerulus
|
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NAME
this refers to the glomerular capsule and the enclosed glomerulus |
renal corpuslce
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(1) can also be called the Bowman's capsule
|
glomerular capsule
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What is filtrate?
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is the raw material that the renal tubules process from the urine
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NAME
this is the raw material that the renal tubules process from the urine |
filtrate
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What kind of tissue does the parietal layer of the glomerular capsule have?
|
simple squamous epthilia
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NAME
this layer of the glomerular capsule is made up of simple squamous epthilea |
parietal layer
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What type tissue does the visceral layer of the glomerular capsule have?
|
consists of highly modifed branching epthilea cells called podocytes
|
|
NAME
this layer of the glomerular capsule consists of highly modifed branching epithelia cells called podocytes |
the visceral
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How do the parietal and the visceral layer of the glomerular capusle differ?
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(1)parietal layer- has simple squamous epthelia (2)visceral layer- consists of highly modifed epthelia branching cells called podocytes
|
|
What are podocytes?
|
are highly modifed epthelia branching cells found in the glomerular capsule
|
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NAME
these are highly modifed epthelia branching cells found in the glomerular capsule |
podocytes
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Podocytes terminated in (1)
|
foot processes
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NAME
these terminate in foot processes |
podocytes
|
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What are filtration slits?
|
are clefts or openings btwn the foot processes
|
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NAME
these are clefts or opening btwn the foot processes |
filtration slits
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Filtration slits are also called (1)
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slit pores
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(1)are also called slit pores
|
filtration slits
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|
What do filtration slits?
|
allow the filtrate to enter the capsular space inside the glomerular capsule
|
|
NAME
these allow the filtrate to enter the capsular space inside the glomerular capsule |
filtration slits
|
|
What does the PCT stand for?
|
proximal convoluted tubule
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NAME
this makes a loop called the loop of Henle then whends and twists as the DCT before emptying into the collecting duct |
PCT
|
|
What is the PCT?
|
makes a loop called the loop of Henle then whends and twists as the DCT before emptying into the collecting duct
|
|
What does the DCT stand for?
|
distal convoulated tubule
|
|
What gives the medullary pyramids there striped appearnce?
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bc the collecting ducts run through them
|
|
NAME
these have a strip appearnce bc the collecting ducts run through them |
medullary pyramids
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|
What is the papillary ducts?
|
deliver urine to the minor calyces via pappillae of the pyramids
|
|
NAME
this delivers urine to the minor calyces via papillae of the pyramids |
papillary ducts
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|
As the collecting ducts approach the renal pelvis, they fuse to form the large (1)
|
papillary ducts
|
|
NAME
as these approach the renal pelivs, they fuse to form the large papillary ducts |
renal pelvis
|
|
What kind of tissue does the renal tubule have?
|
single layer of polar epthilea cells w each of its regions having a unique cellular atomony that reflects the role in processing filtrate
|
|
What are the walls of the PCT like? kind of tissue?
|
are formed by cubiodial epthilea cels w large mitochondria (2)thier lumar surface bear microvilli
|
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NAME
these are formed by cubiodial epthilea cells w large mitochondira, and thier lumar surface bear microvilli |
PCT
|
|
What is are the walls of the loop of Henle likes?
|
has descending and ascending limbs
|
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NAME
the walls of this, have descending and ascending limbs |
the loop of Henle
|
|
What is the thin segment?
|
is the rest of the descending limb of the loop of Henle
|
|
NAME
this is the rest of the descending limb of the loop of Henle |
thin segement
|
|
What kind of tissue does the thin segement have?
|
simple squamous epthiliea freely permeable to water
|
|
NAME
this has simple squamous epthiliea freely permeable to water |
thin segment
|
|
What are the thick segment?
|
is the part of the loop of Henle that in which the epthila becomes cuboidal or even low columnar
|
|
NAME
this is part of the loop of Henle in which the epthiliea becomes cubiodal or even low columnar |
thick segment
|
|
What are (2) of the most important types of cells in collecting ducts?
|
(1)intercalated cells (2)prinicpal cells
|
|
NAME
these are two of its most important cells: intercalated cells and prinicpal cells |
collecting ducts
|
|
What are intercalated cells?
|
are cubodial cells w abundant mircovilli that play a role in maintaining the acid base balance of the blood
|
|
NAME
these are cubodial cells w abundant micorvilli that play a role in maintaining the acid base balance of the blood |
intercalated cells
|
|
What are principal cells?
|
they lack microvilli and help maintain the body's water and Na+ balance
|
|
NAME
these lack microvilli and help maintain the body's water and Na+ balance |
principal cells
|
|
What are cortical nephrons?
|
represent 85% of the nephrons in the kidneys
|
|
NAME
these represent 85% if nephrons in the kidneys |
cortical nephrons
|
|
What are the juxtamedullar nephrons?
|
are located close to the medullar junction and play an important role in the kidney's ability to produce concentrated urine
|
|
nAME
these are located in the medullar junection and play an important role in the kidney's ability to produce conecntrated urine |
juxamedullar nephrons
|
|
Every nephron is assocaited w (1)
|
two capillary beds
|
|
NAME
each of these is assocaited w 2 capillary beds |
nephron
|
|
What are the (2)capillary beds of the nephron?
|
(1)glomerulus (2)peritubular capilaries
|
|
NAME
these have two capillary beds: glomerulus and the pertiubular capillaries |
nephron
|
|
What is the glomerulus capillary bed? (2)
|
(1)has capillares that run parallel for filtration (2)is both fed and drained by the afferent arteriole and the efferent arteriole
|
|
NAME
this has capillaries that run parallel and is speacialzed for filtration and it is both feed and drained by the afferent arteriole and the efferent arteriole |
the glomerulus capillary bed
|
|
What is the big differ btwn the glomerulus cappilary bed compared to all other capillary beds?
|
it is both fed and drained by the efferent arteriole and the afferent arteriole
|
|
Where do the afferent arterioles arise from?
|
the interlobular arterioles that run through the renal cortex
|
|
NAME
this arises from the inerlobular artries that run through the renal cortex |
afferent arterioles
|
|
Why does the afferent arterioles arise from the interlobular arteries that run through the renal cortex? (3)
|
(1)arterioles are high resistance vessels (2)the afferent arteriole has a large diamter then the efferent, the blood pressure in the glomerulus is extraordinarily high for a capillary bed and easily forces fluid and solute out of the blood into the glomerular capsule
|
|
NAME
The is (1)like this because arterioles are high resistance vessels and the afferent arteriole has a large diamter then the efferent, the blood pressure in the glomerulus is extraordinarily high for a capillary bed and easily forces fluid and solute out of the blood into the glomerular capsule |
the afferent arterioles arise from the interlobular arteries
|
|
Most of the (1) (99%) is absorbed by the renal tubule cells and returned to the blood in the pertibular capillary beds
|
filtrate
|
|
Most of the filtrate (99%) is absorbed by the (1) and returned to the blood in the (2)beds
|
(1)renal tubule cells (2)pertiubular capillary beds
|
|
Most of the filtrate (99%) is absorbed by the renal tubule cells and returned to the blood in the (1)
|
pertiubular capillary beds
|
|
What is one differ btwn the pertiubular capillaries and the glomerulus cappilary beds?
|
(1)pertiubular cappilary beds arise from the efferent arterioles draining from the glomeruli (2)the glomerulus capillary beds arise from the inerlobular arteries that run through the renal cortex
|
|
Where do the pertiubular capillary bed arise from?
|
the efferent arterioles draining the glomeruli
|
|
NAME
these arise from the efferent arterioles draining from the glomeruli |
pertibular capillary beds
|
|
What are the pertibular capillaries?
|
they are low pressure, porous capillaries that readily absorb solutes and water from the tubule cells as these substances are reclaimed by the filtrate
|
|
NAME
these are low pressure, porius capillaries that readily absorb solutes and water from the tubule cells as these substances are reclaimed by the filtrate |
pertibular capillaries
|
|
What are vasa recta?
|
are bundles of long striaght vessels that extend deep into the medullar
|
|
NAME
these are bundles of long striaght vessels that extend deep into the medullar |
vasa recta
|
|
In summary, what does the first capillary bed or glomerulus do?
|
produces the filtrate
|
|
NAME
this produces the filtrate |
the glomerulus capillary bed
|
|
What does the secound or peritubular capillary bed do?
|
reclaims most of the filtrate
|
|
NAME
this reclaims most of the filtrate |
the peritubular capillary bed
|
|
Blood flowing through the renal circulation encounters (1)in the afferent and then in the efferent arterioles
|
high resistance
|
|
Blood flowing through the renal circulation encounters high resistance in the (1) and then (2)
|
(1)afferent (2)efferent arterioles
|
|
What is the blood flow like inthe afferent and efferent arteriooles of the renal circulation?
|
has high resistance
|
|
Which has a high blood pressure? renal arteries or renal veins?
|
renal arteries
|
|
Which has a lower blood pressure, renal arteries or renal viens?
|
renal viens
|
|
What is the blood pressure in the renal arteries?
|
about 95 mm Hg
|
|
What is the blood pressure in the renal veins?
|
about 8 mm Hg or less
|
|
NAMe
the blood pressure here is about 95 mm Hg |
the renal arteries
|
|
NAME
the blood pressure here is about 8 mm Hg or less |
renal viens
|
|
What is the differ in blood pressure in the renal viens compared to the renal arteries?
|
(1)renal veins-less (8 mm Hg or less (2)renal arteries is 95 mm Hg
|
|
the renal blood pressure declines from (1)in the renal arteries to about (2) in the renal viens
|
(1)95 mm Hg (2)8 or less mm Hg
|
|
The renal blood pressure declines from 95 mm Hg in the (1)to about 8 or less mm Hg in the (2)
|
(1)renal arteries (2)renal veins
|
|
Each nephron has a region called the (1)
|
juxtaglomerular apparatus
|
|
NAME
each of these has a region called the juxtaglomerular apparatus |
nephron
|
|
What is the juxtaglomerular apparatus?
|
is where the initial portion of its coiling DCT lies against the afferent arteriole feeding the glomerulus
|
|
NAME
this is where the inital portion of the its coiling DCT lies against the afferent arteriole feeding the glomerulus |
juxtaglomerular apparatus
|
|
What does JG cells stand for?
|
juxtaglomerular cells
|
|
What are JG cells?
|
are enlarged smooth muscle cells w prominent secertory granules containing renin
|
|
NAME
these are enlarged smooth muscle cells w prominent secretory granule containing renin |
JG cells
|
|
Where are JG cells found?
|
in the arteriloe walls of the juxtaglomerular apparatus
|
|
NAME
these are found in the arteriole walls of the juxtaglomerular apparatus |
JG cells
|
|
what is macula densa?
|
is a group of tall, closely packed DCT cells that lie adjacent to JG cells
|
|
NAME
these are a group of tall, closely packed DCT cells that lie adajacent to JG cells |
macula densa
|
|
What are mesangial cells?
|
surround the glomerular capillaries and seemginly part of the JGA have phaogcytic and contractile properites
|
|
surround the glomerular capillaries and seemginly part of the JGA have phaogcytic and contractile properites
|
mesaangial cells
|
|
Where is the filtration membrane located?
|
btwn the blood and the interior of the glomerular capsule
|
|
NAME
this lies btwn the blood and the interior of the glomerular capsule |
filtration mebrane
|
|
what is the filtration membrane>
|
it is a porous membrane that allows free passage of water and soultes smaller than plasma proteins
|
|
NAME
it is a porous membrane that allows free passage of water and soultes smaller than plasma proteins |
filtration mebrane
|
|
What are the (3)layers of the filtration membrane?
|
(1)the fenestrated endothelium of the glomerular capillaries (2)the visceral membrane of the glomerular capsule made of podocytes (3)the intervening basement membrane composed of the fused basal laminae of the other layers
|
|
NAME
this has three layers: (1)the fenestrated endothelium of the glomerular capillaries (2)the visceral membrane of the glomerular capsule made of podocytes (3)the intervening basement membrane composed of the fused basal laminae of the other layers |
filtration membrane
|
|
NAME
in the filtration membrane, these allow for passage of all plasma components but not blood cells |
capillary pores
|
|
in the filtration membrane, the capillary pores allow for (1)
|
passage of all plasma components but not blood cells
|
|
the filtration membrane also seems to confer (1)
|
eletrical selecivity on the filtration process
|
|
NAME
this also seems to confer eletrical selecivity on the filtration process |
filtration process
|
|
What is the charge of most of the glycoprotiens in the filtration membrane?
|
negative
|
|
How does the filtration membrane confect eletrical selecivity?
|
by most the proteins are negativly charged (2)they repel other macromolecular anions and hinder thier passsage
|
|
NAME
this happens bc most of by most the proteins are negativly charged and they repel other macromolecular anions and hinder thier passsage |
electrical selectivity in the filtration membrane
|
|
NAME
these organs consume 20 to 25 % of the body's oxygen |
kidneys
|
|
How much total oxygen do the kidneys consume?
|
20 to 25%
|
|
What does filtrate contain?
|
everything found in the blood plasma except protiens
|
|
NAME
this contains everything found in the blood plasam except proteins |
filtrate
|
|
What happens to filtrate by the time it reaches the collecting ducts?
|
it has lost most of its nutrient and ions and is now urine
|
|
NAME
when this has percolated into the collecting ducts, it has lost most of its water, nutrients, and ions, what remains is urine |
filtrate
|
|
What is urine?
|
is mostly metabolic wastes and unneed substances
|
|
NAME
this is mostly metabolic wastes and unneeded substances |
urine
|
|
How much do the kidneys process of blood-dervied flood a day?
|
about 180 L
|
|
NAME
this organ processes about 180 L of blood derived fluid daily |
kidneys
|
|
How much urine actually leaves the body ?
|
1%
|
|
NAME
only about 1% of this actually leaves the body as this, and the rest returns to circulation |
urine
|
|
What are (3)major processes of urine formation and adjustment of the blood composition?
|
(1)glomerular filtration by the glomeruli (2)tubular reabsorption (3)secretion in the renal tubules
|
|
NAME
this inolves three major processes: glomerular filtration by the glomeruli, tubular reabsorption, and secretion in the renal tubules |
urine formation and adjustment of the blood compostion
|
|
What is the glomerular filtration?
|
is a passive, nonselective process in which the hydrostatic pressure forces fluids and soultes through the membrane
|
|
NAME
is a passive, nonselective process in which hydro pressure forces fluids and solultes through the membrane |
glomerular filtration
|
|
NAME
this can be veiwed as a simple mechnical fibers |
the glomeruli
|
|
Why can the glomeruli be viewed as simple mechincal fibers?
|
bc filtrate formation does not consume metabolic energy
|
|
T or F
filtrate formation does consume metabolic energy |
false
|
|
Does filrate formation require metabolic energy?
|
no
|
|
Which is a much more efficient filter, glomerulus or other capillary beds?
|
glomerulus
|
|
Why is the glomerulus a more efficeint filter compared to other capillary beds? (2)
|
(1)its filtration membrane has a large surface area and is thousands of times more permeable to water and solutes (2)glomerular blood pressure is much more higher than in other capillary beds`
|
|
NAME
this is more more efficient filter because its filtration membrane has a large surface area nd is thousands of times more permeable to wter and solutes and glomerular blood pressure is much more higher than in othe capillary beds |
glomerulus
|
|
What can of molecules can pass through the renal tubule?
|
molecules smaller than 3 nm in diamter such as water, glucose, amino acids, and nitrogenous bases
|
|
NAME
only molecules smaller than 3nm in diamter such as water, glucose, amino acids,and nitrogenous bases can pass through this |
the renal tubule
|
|
Keeping the (1) in the capillaries helps to maintain th colloid osmotic pressure of the glomerular blood, preventing the losss of all water to the renal tubules
|
plasma proteins
|
|
NAME
this helps to maintian the coloid ostmoticp pressure of the glomerular blood, preventing the loss of all water to the renal tubules |
the keeping of plasma protiens in the capillaries
|
|
What does the keeping of plasam proteins in the capillaries do?
|
helps to maintian the coloid ostmoticp pressure of the glomerular blood, preventing the loss of all water to the renal tubules
|
|
What is the NFP?
|
is resposnible for filrate formation and involves foreces acting at the glomerular bed
|
|
NAME
this is responsible for filtrate formation and inolves forces acting at the glomerular bed |
NFP
|
|
What does NFP stand for?
|
net filtration pressure
|
|
What does HPg stand for?
|
glomerular hydrostatic pressure
|
|
What is HPg?
|
is the chief force pushing water and solutes out of the blood and across the filtration membrane
|
|
NAME
this is the cheif force pushing water and solutes out of the blood and across the filtration mebrane |
HPg
|
|
What are two forces oppose that drive fluids back into the glomerular capillaries the HPg? (2)
|
(1)OPg (2)HPc
|
|
NAME
this is opposed by two forces that drive fluids back into the glmoerular capillaries: OPg and HPc |
HPg
|
|
What does OPg stand for?
|
colloid osmotic pressure of the glomerular blood
|
|
What does HPc stand for?
|
capsular hydrostatic pressure
|
|
What are (2) filtration opposing forces of HPg and fluids in the glomerular capsule
|
(1)OPg (2)HPc
|
|
What does GFR stand for?
|
glomerular filtration rate
|
|
What is the GFR?
|
is the vol of filtrate formed each min
|
|
NAME
this is the vol of filtrate formed each min |
GFR
|
|
What are factors that govern the GFR? (3)
|
(1)total surface area avaivable for filtration (2)filtration membrane permeability (3)NFP
|
|
NAME
this is governed by three factor such as the total surface area available for filtration, and membrane permeability and NFP |
GFR
|
|
Why can hudge amounts of filtrate be produced by the kidneys?
|
bc glomerular capillaries are exceptionally permeable
|
|
What is the equation for get NFP?
|
NFP=HPg-(OPg+HPc)
|
|
NAME
this equals HPg-(OPg+HPc) |
NFP
|
|
Because (1), any change in any pressures acting at the filtration membrane
|
GFR is directly proportional to the NFP changes both the NFP and the GFR
|
|
Because GFR is directly proportional to the NFP, (1)
|
any change in pressures acting on the filtration membrane changes both the NFP and GFR
|
|
GFR is directly proportional to the (1)
|
NFP
|
|
(1)is directly proportional to the NFP
|
GFR
|
|
An (1)increses the GFR
|
arterial blood pressure
|
|
An increase in arterial blood pressure, (1)
|
increases the GFR
|
|
Dehydration inhibits (1)
|
filtrate formation
|
|
(1)inhbits filtrate formation
|
dehydration
|
|
Why is maitaining a fairly constant GFT important?
|
bc resabsorption of water and other substances from the filtrate depends partly on the rate at which it flows through the renal tubules
|
|
What does the reabsorption of water and other substances from filtrate depend on?
|
the partly the rate at wchih it flows through the renal tubules
|
|
NAME
this partly depends on the rate at which it flows through the renal tubules |
the reabsorption of water ando ther substance from filtrate
|
|
What happens if massiave amounts of filtrate form?
|
the flow is too rapid for needed substances to be reasborbed fast enough and some are lost in the urine
|
|
NAME
this happens if flow is too rapid for needed substances to reabsorbed fast enough and some are lost in urine |
if massive amounts of filtrate form
|
|
What happens if flitrate is scanty and flows slowly?
|
nearly all of it will absorbed including most of the waste that are normally disposed of
|
|
NAME
this happens if nearly all of it is absorbed including most of the waste that are normally disposed of |
if the filtrate is scanty and flows slowly
|
|
How is GFR held relatively constant?
|
by both intrinsic and extrinsic controls which regulate renal blood flow
|
|
What regulates renal blood flow?
|
both instrinsic and extrinsic controls
|
|
What is a example of a intrinsic control that regulate the renal blood flow?
|
renal autoregulation
|
|
NAME
this is a ex of a intrisnic control that regulates the renal blood flow |
renal autoregulation
|
|
What is renal autoregulation?
|
is the adjustment of its own resistance to blood flow
|
|
NAME
this is the adjustment of its own resistance to blood flow |
renal autoregulation
|
|
What does the renal autoregulation allow the kidney to do?
|
maintain a nearly constant GFR despite fuctutions in a systemic arterial blood pressure
|
|
NAME
this helps the kidneys to maintain a nearly constant GFR despite functions in a systemic arterial blood pressure (more specfic ) |
intrinisc controls such as renal autoregulation
|
|
What are (2) types of controls of renalautoregulation?
|
(1)a myogenic mechanism (2)a tubuloglomerular feedback mechanism
|
|
NAME
this has two controls: a myogenic mechanism and a tubuoglmoerular feedback mechanism |
renalautoregulation
|
|
What is myogenic mechanism?
|
reflects the tendecny of vascular smooth muscle to contract when streched
|
|
NAME
this reflects the tendecy of vascular smooth muscle to contract when streched |
myogenic mechanism
|
|
A increase in systemic blood pressure will cause (1)
|
the afferent arterolies to constrict which restricts the blood flow into the glomerulus and prevents glomerular blood pressure from rising to damaging levels
|
|
NAME
this cna cause the afferent arterolies to constrict which restricts the blood flow into the glomerulus and prevents glomerular blood pressure from rising to damaging levels |
a increase in systemic blood pressure
|
|
What does a decrease in systemic blood pressure cause?
|
the diliation of afferent arteriole and raises glomerular hydrostatic pressure
|
|
NAME
this causes the dilation of afferent arterioles and raises the glomerular hydrostatic pressure |
a decrease in systemic blood pressure
|
|
What directs the tubuloglomerular feedback mehcanism?
|
the macula densa cells of the jxxtaglmoerular apparatus
|
|
NAME
this is directed by the macula densa cells of the juxtaglmoerular apparatus |
the tubuloglomerular feedback mechanism
|
|
NAME
these respond to filtrat flow and osmotic signals |
macula densa cells
|
|
What do macula densa cells respond to ?
|
filtrate flow and osmotic signals
|
|
What happens when macula densa cells are exposed to slowly flowing filtrate or filtrate w low osmolality?
|
thier signals promote vasodilation of the afferent arterioles-- which allows more blood flow into the glomerulus and thus increases the NFP and GFR
|
|
NAME
this happens when thier signals promote the vasoldilation of the afferent arterioles--- which allows for more blood flow into the glomerulus and thus increases the NFP and GFR |
when macula densa cells are exposed to slowly flowing filtrate or filtrate w low osmolarity
|
|
What happens when macula densa cells are exposed to filtrate that is flowing rapidly and/or has a high sodium and chloride content?
|
the macula densa cells prompt generation of vasoconstritor chemcials that causes intense renal vasoconstriction-- that hinders blood flow into the glomerulus which decreases the GFR and allows more filtrate processing
|
|
NAME
when this happens, the macula densa cells prompt generation of vasoconstricotor chemicals that causes intesnse renal vasoconstriction-- that hinders the blood flow into the glomerulus which decreases the GFR and allows more filtrate processing |
when the macula densa cells are exposed to filtrate that is flowing rapidly and/or has a high sodium chloride content
|
|
T or F
the instrinsic controls can handle a extermly low systemic blood pressure such as one that might result from a serious hemorphage |
false
|
|
Can the instrinisic controls hand a extermly low systemic blood pressure such as on that might result from a serious hemorphage?
|
no
|
|
What is below what amount can the intrinsic controls not handle a low systemic blood pressure?
|
anything below 90 mm Hg
|
|
NAME
anything below this systemic blood pressure and autoregulation will cease |
90 mm Hg
|
|
What is the purpose of the extrinisic controls regulating the GFR?
|
is to maintain the systemic blood pressure
|
|
Draw what happens when their is low blood pressure in the renal blood vessels?
|
p 1008
|
|
What happens when the vol of extracellular fluid is normal and the sympathic nervous system is at rest?
|
the renal blood vessels are maximally dilated and the renal autoregulations prevail
|
|
NAME
during this, the renal blood vessels are maximally dilated and the renal autoregulations prevail |
when the vol of extracellular fluid is normal and the sympathic nervous system is at rest
|
|
What happens when during extreme stress or emergency when it is neccessary to shunt blood to vital organs?
|
neural controls may overcome renal autoregulatory mechiansims
|
|
NAME
when this happens, neural controls may overcome renal autoregulatory mechanisms |
during exterme stress or emergency when it is neccessary to shunt the blood to the vital organs
|
|
When is the renin-angiotensin mechanism triggered?
|
when various stimuli cause JG cells to release renin
|
|
NAME
this is triggered when various stimuli cause JG cells to release renin |
renin-angiotensin mechanism
|
|
What does renin act on?
|
angiotensingoen
|
|
NAME
this acts on angiotensingoen |
renin
|
|
What is angiotensinogen?
|
is a plasma globulin made both by the liver and locally by the PCT cells to release angiotensin I
|
|
NAMe
this is a plasma globulin made both by the liver and locally at the PCT cells to release angiotensin I |
angiotensingoen
|
|
Angiotensin I is converted to (1)
|
angiotensin II
|
|
What is does ACE stand for?
|
angiotensin converting enzyme
|
|
What is ACE?
|
converts angiotensin I into angiotensin II
|
|
NAME
this converts angiotensin I into angiotensin II |
ACE
|
|
What is angiotensin II?
|
is a potent vasoconstrictor that activates smooth muscle of arterioles throughout the body, raising mean arterial blood pressure
|
|
NAME
this is a potent vasoconstrictor that activates, smooth muscle of arterioles throughout the body, raising mean arterial blood pressure |
angiotensin II
|
|
What are some of the several factors that can trigger renin release? (3)
|
(1)reduced strech of the granular JG cells such as a drop in systemic blood pressure below 80 mm Hg (2)stimulation of the JG cells by input from activated macula densa cells (3)direct stimulation of JG cells via B1 adrenergic receptors by renal sympthetic nerves
|
|
NAME
this can be caused by (1)reduced strech of the granular JG cells such as a drop in systemic blood pressure below 80 mm Hg (2)stimulation of the JG cells by input from activated macula densa cells (3)direct stimulation of JG cells via B1 adrenergic receptors by renal sympthetic nerves |
the release of renin
|
|
What are some other factors (not normally) that can trigger the production of renin? (4)
|
(1)Prostoglandins (2)nitric oxide (3)adenosine (4)endothelin
|
|
NAME
these are otehr factors that ca trigger the production of this: prostoglandins, nitric oxide, adenosine, and endoethelin |
renin
|
|
What are (2) types of prostaglandins?
|
(1)PGE2 (2)PGI2
|
|
NAME
these include PGE2 and PGI2 |
prostaglandins
|
|
What are prostglandins?
|
are vasodilators produced in response to a symapathic stimulation and angiotensin II, are believed to counteract the effect of noneprinpehrin and angiotensin II on the kidney
|
|
NAME
are vasodilators produced in response to a symapathic stimulation and angiotensin II, are believed to counteract the effect of noneprinpehrin and angiotensin II on the kidney |
prostglandins
|
|
NAME
this is a potent vasodilator produced by the vascular endoethelum |
nitric oxide
|
|
What is adenosine?
|
it functions as a vasiodilator systemically, and constricts the renal vascularture
|
|
NAME
this functions as a vasiodilator systemically and counteract the renal vascularture |
adenosine
|
|
What is endothelin?
|
is secreted by the vascular endothelium and selected tubule cells, endothein is a powerful vasoconstrictor
|
|
NAME
is secreted by the vascular endothelium and selected tubule cells, endothein is a powerful vasoconstrictor |
endothelin
|
|
What is anuria?
|
is abnormally low urinary output
|
|
NAME
this refers to a abnormally low urinary output |
anuria
|
|
What might a anuria indicate?
|
(1)that glomerular blood pressure is too low to cause filtration (2)due to the nephrons ceaseing to function
|
|
NAME
this can be caused by when glomerular blood pressure is to low, but it is normally results from the when nephrons cease in function |
anuria
|
|
What keeps on plasma from being drained away as urine?
|
the fact the most of our tubule contents are quickly reclaimed and returned to our blood
|
|
NAME
if werent for the fact that most of our tubule contents are quickly reclaimed and returned to our blood-- this would happen |
our plasma would be drained away w our urine
|
|
What is the tubular reabsorption?
|
refers to the process by which our blood plasma is quickly reclaimed and returned to the blood
|
|
NAME
this refers to the process by which our blood plasam is quickly reclaimed and returned to the blood |
tubular reabsoprtion
|
|
When does the tubular reabsorption process start?
|
it is a transepihtelial process that begins as soon as the filtrate enters the proximal tubules `
|
|
NAME
this is a transepithetial process that begins as soon a the filtrate enters the proximal tubules |
tubular reabsoprtion process
|
|
in order to reach the blood, what are (3) membrane barriers transporters must go through?
|
(1)luminal and basolateral membranes of tubule cells (2)the endoethelium of the pertibular capillaries
|
|
NAME
in order to do this: they need to go through these three membrane barriers: luminal and basolateral membranes of the tubule cells, and the endoethelium of peritbular capillaries |
transporters to reach the blood
|
|
Why is movement btwn cells limited in the tubule cells?
|
bc of tight junctions
|
|
NAME
tight junctions in tubule cells do this |
make movement btwn cells limited
|
|
T or F
viturally all organic nutrients such as glucose and amino acids are reabsorbed to maintain or restore nromal plasma concentrations |
true
|
|
Virtuall all (1)are reabsorbed to maintian or restore normal plasma concentrations
|
organic nutrients such as glucose and amino acids
|
|
Vitrually, all organic nutrients are reabsorbed to (1)
|
maitain or restore normal plasma conecntrations
|
|
What kind of energy does the reabsorbtion process use?
|
either passive or active
|
|
NAME
this is the single most abundant cation in the filtrate |
NA
|
|
NAME
about of 80% of its energy used for active transport is devoted to thier reabsorption |
NA
|
|
How much energy is used by NA ?
|
about 80% of its energy used for active transport is devoted to thier reabsorption
|
|
What is the most abundant cation in the filtrate?
|
na
|
|
NA is the (1)in filtrate
|
the most abundant cation
|
|
How is sodium reasborbed?
|
is almost always reabsorbed actively via the transcellular route
|
|
NAME
this is almost always reabsorbed actively via the transcellular route |
NA
|
|
What are (2)processes that promote active Na reabsorption to occur in each tubule segment?
|
(1)when NA enters the tubule cells from the filtrate at the luminal membrane and then (2)is actively transported out of the tubule cells by a Na+-K ATPase pump present in the basolateral membrane
|
|
NAME
this can be occur when Na enters the tubule cells from the filtrate at the luminal membrane and the is actively transported out of the tubule cells by a Na+-K ATPase pump present in the basolateral membrane |
active Na reabsorption
|
|
Why is the movement of Na+ cells and other absorbed substances so rapid?
|
bc of the low hydrostatic pressure and high osmatic pressure
|
|
What does the active pumping of Na+ restult in?
|
a strong electrochemical gradiant that favors its passive entry at the luminal face via cotransport or active transport carriers or via facilated diffusion
|
|
NAME
this results in a strong electrochemical gradiant that favors its passive entry at the luminal face via cotransport or active transport carriers or via facilated diffusion |
the active pumping of Na+
|
|
Why does the active pumping of Na+ result ing a strong electrochemical gradiant that favors its passive entry at the luminal face via cotransport? (2)
|
(1)the pump maintains the intracellular Na+ concentrations at low levels (2)the K+ pumped into the tubule cell almost immediatly diffuses out into the inter of the tubule cells w a net negative charge
|
|
NAME
this will occur bc the pump maitains the intracellular Na+ conecntrations at low levels and the K+ pumped into the tubule cells almost immediatly diffuses out into the inter of the tubule cells w a net negative charge |
tive pumping of Na+ result ing a strong electrochemical gradiant that favors its passive entry at the luminal face via cotransport
|
|
What is absorbed in the proximal convoulated tubule? (7)
|
Na ions (2)viturally all nutrients (3)Cations (4)Anions (5)water (6)Urea and lipid soluble soultes (7)small protiens
|
|
NAMe
the following substances are reasborbed here: Na ions, virtually all nutrient, cations, anions, water, urea, and lipid soutles, and small protiens |
in the proximal convoulated tubule
|
|
What is the passive reabsorption?
|
refers to when substances move along thier electrochemical gradient w/out the use of ATP
|
|
NAME
this refers to wehn substances move along thier electrochemical gradient w/out the use of ATP |
passive reabsorption
|
|
What are aquaphorins?
|
are water filled pores
|
|
NAME
these are water filled pores |
aquaphorins
|
|
What is obligatory water reabsorption?
|
refers to the sodium linked water flow
|
|
NAME
refers to when water is "obliged " to follow salt |
obligatory water reabsorption
|
|
NAME
this refers to the sodium linked water flow |
obligatory water reabsorption
|
|
Why are aquaphorins virtually absent in the distal tubules and collecting duct membranes unless ADH levels are high?
|
bc of the obligatory water reabsorption
|
|
NAME
these vitrually absent in distal tubules and collecting duct unless ADH levels increase |
aquaphorin
|
|
Are there aquaphorin in distal tubules and collecting ducts?
|
no unless ADH levels increase
|
|
Water moves by osmosis, a process adided by (1)
|
aquaphorins
|
|
How are Na+ reabsorbed?
|
primary by active transport via ATP dependent Na+-K carriers set
|
|
NAME
these are primary reabsorbed by active transport via ATP dependent Na+-K carriers |
Na+
|
|
NAME
this sets up eletrochemical gradient for passive solute diffusion, osmosis, and secondary active transport of Na_ |
the reabsorbtio of Na+
|
|
What does the reasborbtion of NA trigger?
|
sets up a eletrochemcial gradient for passive solute diffusion, osmosis, and secondary active transport of Na+
|
|
How are virtually all nutrients reabsorbed in the proximal convoluted tubule?
|
by active transport or (2)cotransport w Na+
|
|
NAME
these substances are reabsorbed by active transport or cotransport w Na+ |
virtually all nutrients in the proximal convoluted tubule
|
|
How are cations substance reabsorbed in the proximal convoluted tubule?
|
(1)passive transport driven by electrochemical gradient for most
|
|
NAME
most of these substances are reabsorbed by passive transport driven by electrochemical gradient |
cations in the proximal convoluted tubule
|
|
How is K+ reabsorbed in the proximal convoluted tubule?
|
by the paracellular route
|
|
NAMe
this cation is reabsorbed by the paracellular route |
K+ in the proximal convoluted tubule
|
|
How are anions such such as Cl- and HCO3- reabsorbed in the proximal convoluted tubule?
|
by passive transport (2)paracellular diffusin driven by electrochemical gradient (3)active transport w Na+
|
|
NAME
these substances are reabsorbed by passive transport, paracellular diffusion driven by electrochemical gradient and the active transport of Na+ |
anions such as Cl- and HCO3- in the proximal convoluted tubule
|
|
How is water reabsorbed in the proximal convoluted tubule?
|
by osmosis
|
|
NAME
this substance is reabsorbed by osmosis |
water
|
|
How is urea and lipid soluble solutes reabsorbed by in the proximal convoluted tubule?
|
by passive diffusion driven by the electrochemical gradient created by the osmotic movement of water
|
|
NAME
these substances, are reabsorbed by the passive diffusion driven by the electrochemcial gradient created by the osmotic movement of water |
urea and lipid soluble soultes in the proximal convoluted tubule
|
|
How are small protiens in the proximal tubule reasborbed?
|
endocytosed by tubule cells and digested to amino acids w/in tubule cells
|
|
NAME
this substance, is reabsorbed by endocytos by tubule cells and digested to amino acids w/in tubule cells |
small proteins in the proximal convoluted tubule
|
|
What are some substance reabsorbed by secondary active transport (4)?
|
glucose (2) amino acids (3)lacatate (4) vitamins (5)most cations
|
|
How are glucose, amino acids, lacatate, vitamins, anbd most cations reabsorbd?
|
by secondray active transport
|
|
What does Tm stand for?
|
transport miximimum
|
|
What is Tm ?
|
exculding Na, it refers to nearly every substance that is actively reabsorbed
|
|
NAME
exucluding Na, this refers to nearly every substance that is actively reabsorbd |
Tm
|
|
What doest Tm reflect?
|
the number of carriers in the renal tubules available to ferry each particular substance
|
|
NAME
this reflects the number of carriers in the renal tubules available to ferry each particular substance |
Tm
|
|
What has hight Tm values?
|
glucose
|
|
What does mean that a carriers are saturated?
|
it means that all carriers are bound to the substance they transport
|
|
NAME
this means that all carriers are bound to the substnace they transport |
saturated carriers
|
|
What happens if the carriers are saturated in the urine?
|
the excess is excerted in the urine
|
|
T or F
substances cannot be reabsorbed or reabsorbed incompletely |
false
|
|
Why are some substances not reaborsbed or are reabsorbed incompletely? (3)
|
(1)lack of carreirs (2)are not lipid soluble (3)are too large to pass through plasma membrane pores of tubular cells
|
|
NAME
this can happen because of lack of carriers, substances not lipid souble, and/or are too large to pass through the plasma membrane pores of tubular cells |
refers to when some substances are not reabsorbed or are reabsorbed incomplteltly
|
|
What are (3) types of nonreasborbed substances?
|
(1)urea (2)creatinine (3)uric acid
|
|
What are the most active reabsorbers?
|
PCT cells
|
|
NAME
these are the most active reabsorbers |
PCT cells
|
|
NAME
the bulk of the selective or active transport depedent, reabsorption of electrolytes is reabsorbed here |
loop of Henle
|
|
PCT cells are the (1)
|
most active reabsorbers
|
|
The bulk of (1) occurs in the loop of Henle
|
the selective or active transport dependent, reabsorption of electroyltes
|
|
How is water absorbed in the descending limb of the loop of Henle?
|
osmosis
|
|
What does the descending limb of the loop of Henle reabsorb?
|
water
|
|
What does the ascending limb of the loop henle reabsorb? (5)
|
(1)Na+ (2)Cl- (3)K+ (4)Ca2+ (5)Mg2+
|
|
NAME
this reabsorbes the following: Na+, Cl-, K+, Ca2+, and Mg2+ |
the ascending limb of the loop Henle
|
|
How is Na+, Cl, and K+ reabsorbed by the ascending loop of Henle? (3)
|
active transport of Cl- and Na+ via Na+-K+-2Cl- cotransporters in the thick portion (2)also paracellular transport (3)Na+H- antitransport
|
|
NAME
this can be reabsorbed by active transport of Cl-and Na+ via Na+-K+-2Cl- cotransporters in the thick portion and also by paracellular transport and Na+H+ antitransport |
Na+, Cl- and K+ in the ascending loop of Henle
|
|
How can Ca2+ and Mg2+ be reabsorbed in the ascending loop of Henle? (2)
|
(1)passive transport driven by electrochemical gradient (2)paracellular route
|
|
NAME
this can be reabsorbed by passive transport driven by electrochemical gradient and paracellular route |
Ca2+ and Mg2+ in the ascending limb of the loop of Henle
|
|
T or F
waters can leave the ascending loob not the dsecending limb of the loop of Henle |
false
|
|
T or F
more eletrolytes are reabsorbed in the loop of Henle. However, K+ recyles -- it is reabsorbed in the ascending limb and secreted from the descending limb |
true
|
|
More eletroyltes are reabsorbed in the loop of Henle However, (1)recyltes it is reabsorbed in the ascendign limb and secreted in the descending limb
|
K+
|
|
More eletroyltes are reabsorbed in the (1) however K+ recyles-- it is reabsorbed in the (2) and secreted in the (3)
|
(1)loop of Henle (2)ascending limb (3)descending limb
|
|
How is Na+ reabsorbed in the DCT?
|
by primary active transport and requires aldosterone
|
|
NAME
this is reabsorbed by the primary active transport and requires aldosterone |
Na in the DCT
|
|
How is Ca2+ reabsorbed in the DCT?
|
by PTH mediated primary active transport via ATP dependent Ca2+ carrier or Na+/Ca2+ exchanger in basal membrane
|
|
NAME
this is reabsorbed by the PTH meidated primary active transport via ATP dependent Ca2+ carrier exchnager in the basal membrane |
Ca2+ in the DCT
|
|
How is the Cl- reabsorbed in the DCT?
|
by diffusion following the electrochemical gradient created by the active reabsorption of Na+ and (2)also cotransported w Na+
|
|
NAME
this is transported by the diffusion following the electrochemical gradient created by the active reabsorption of Na+ and also cotransported w Na_ |
Cl- in the DCT
|
|
NAME
this can be reabsorbed by osmosis, and faculative water reabsorption, |
water in the DCT
|
|
How is water in the DCT reabsorbed?
|
by the osmosis and faculative water reabsorption
|
|
How are Na+, H+, K+, HCO3, and Cl -does the reabsorbed in the collecting ducts?
|
aldosterone-mediated primary active transport of Na+ and the medullary gradient create the conditions neccesary for passive transport of some HCO3- and Cl
|
|
What does water reabsorption in the water in the DCT and the collecting ducts depend on?
|
the abiltiy of ADH to increase the porosity of tubule epithelium
|
|
NAME
reabsorption of this depends on the ability of to increase the porosity of tubule epithelium |
water
|
|
How is urea reabsorbed in the collecting ducts?
|
by faciliated diffusion in response to concentration gradient in the deep medulla region and most remains in the medullay interstitial space
|
|
NAME
this is reabsorbed by the by faciliated diffusion in response to concentration gradient in the deep medulla region and most remains in the medullay interstitial space |
urea in the collecing ducts
|
|
What can the collectin ducts reabsorb? (7)
|
(1)Na_ (2)H_(3)k+(4)HCO3- (5)Cl- (6)water (7)urea
|
|
NAME
this can reabsorb the following: Na,H+, K+, HCO3-, Cl-, water, and urea |
the collecting ducts
|
|
What can the DCT reabsorb? (4)
|
(1)Na+ (2)Ca2+ (3)Cl- (4)Water
|
|
NAME
this can reabsorb Na+, Ca2+, Cl- and water |
DCT
|
|
What are some effects of aldosterone? (3)
|
(1)fine tunes the reabsorption of the remaining Na2+ (2)facilitate water absorption as Na2+ is reabsorbed (3)reduces K+ conectrations
|
|
NAME
this fine tunes the reabsorption of the remaining Na2+, faciliate water absorption as Na2_ is reabsorbed, and reduces the K+ concetrations |
aldosterone
|
|
What does ANP stand for?
|
atrial natriuretic peptide
|
|
What is ANP?
|
reduces blood Na+ thereby decreasing blood vol and blood pressure
|
|
NAME
this reduces blood Na+ thereby decreasing blood vol and blood pressure |
ANP
|
|
What are some ways taht ANP works to lower blood Na+ levels?
|
(1)acts directly on medullary collecting ducts to inhibit reabsorption (2)indirectly inhibits Na+ reabsorption by counteracting the stimulatory effeect of Angiotensins II on aldosterone secretion by the adrenal cortex (3)indirectly stimulates the renal arterioles, thereby reducing water reabsorption and blood vol
|
|
NAME
this reduces Na+ levels by acting directly on medullary collecting ducts to inhibit reabsorption, indirectly inhibits Na+ reabsorption by counteracting the stimulatory effeect of Angiotensins II on aldosterone secretion by the adrenal cortex, and indirectly stimulates the renal arterioles, thereby reducing water reabsorption and blood vol |
ANP
|
|
What are (2)ways to clear plasma of unwanted substances?
|
(1)the faliure of tubule cells to reabsorb some solutes (2)tubular secretion
|
|
NAME
the faliure of tubule cells to reabsorb some solutes and tubular secretion helps to do this |
clear plasma of unwanted substances
|
|
What is tubular secretion?
|
is reabsorption in reverse
|
|
NAME
this is reabsorption in reverse |
tubular secretion
|
|
T or F
thus the urine eventually excreted contains both filtered and secreted substances |
true
|
|
Urine eventually excreted contain both (1)
|
filtered and secreted substances
|
|
What is the major site of secretion?
|
PCT
|
|
NAME
this is the major site of secretion |
PCT
|
|
PCT is the major site of (1)
|
secertion
|
|
What is osmolality?
|
is the number of solutes particles dissolved in one liter of water
|
|
NAME
this refers to the number of solutes particles dissolbed in one liter of water |
osmolality
|
|
What does the osmolality reflect?
|
the solution's ability to cause osmosis
|
|
NAME
this reflects the solution's ability to cause osmosis |
osmolality
|
|
What is used to measure /desecribe the solute concentration of body fluids?
|
mOsm
|
|
mOsm is used to measure/ describe the (1)
|
solutes concentration of body fluids or osmolality
|
|
What does mOsm stand for?
|
milliosmol
|
|
What should the solute load of body fluids or osmolality be kept at in the renal cortex?
|
300 mOsm
|
|
300 mOsm is "ideal" osmolality of the (1)
|
renal cortex
|
|
How are the kidneys able to keep the osmolality of the renal cortex at 300 mOsm?
|
through the countercurrent mechanism
|
|
What does the countercurrent mechanism help the kidneys to do?
|
keeo the osmolality of the renal cortex at 300 mOsm
|
|
What does the term countercurrent mean?
|
it means that something flows in the opposite direction through the adjacent channels
|
|
NAME
this means that something flows in the opposite direction through the adjacent channels |
countercurrent
|
|
What does the countercurrent mechanism inolve in the kidneys?
|
the interaction btwn the flow of filtrate through the long loops of the Henle of juxtamedullary nephrons and the flow of the blood through the adjacent vasa recta blood vessels
|
|
NAME
this involves the the interaction btwn the flow of filtrate through the long loops of the Henle of juxtamedullary nephrons and the flow of the blood through the adjacent vasa recta blood vessels |
countercurrent mechanism
|
|
What is countercurrent multiplier?
|
is the loop of Henle
|
|
The loop of Henle is the (1)
|
countercurrent multipler
|
|
What is the countercurrent exchanger?
|
is the vasa recta blood vessels
|
|
The vasa recta blood vessels are the (1)
|
countercurrent exchanger
|
|
The osmolality increases from (1)to about (2) mOsm on the deepest part of the renal medulla
|
(1)300 (2)1200
|
|
What does the osmalility increase to in the deepest part of the renal medulla?
|
1200 mOsm
|
|
What are (3) factors that keep the countercurrent multipler functioning?
|
(1)the decending limb of the loop of Henle is relatvily impermeable to solutes and freely permeable to water (2)the ascending limb is permeable to solutes, but not to water(3) the collecting ducts in the deep medullary regiosn are permeable to urea
|
|
NAME
this is able to function because (1)the decending limb of the loop of Henle is relatvily impermeable to solutes and freely permeable to water (2)the ascending limb is permeable to solutes, but not to water(3) the collecting ducts in the deep medullary regiosn are permeable to urea |
the countercurrent multipler
|
|
When does the loop Henle reach a osmolality of 1200 mOSm?
|
at the elbow of the loop or vasa recta
|
|
At the elbow of the loop of Henle (also called the vasa recta, the osmolality can reach as high as (1)
|
1200 mOsm
|
|
Where does most of the reabsorption of Na+, K+, and -2Cl- take place?
|
in thick segments of the loop of Henle
|
|
What is the osmolaltiy in the ascending loop of Henle?
|
200 mOsm
|
|
The (1) concentration in the filtrate is very high in the ascending limb of the loop of Henle
|
Na+ and Cl-
|
|
The concentration of Na+ and Cl- in the filtrate is very high in the (1)
|
ascending limb of the loop of Henle
|
|
As the filtrarte flows from the cortex to the medulla in the descending limb, water leaves the tubule by osmosis and the filtrate osmolaity increases from (1) to (2)
|
(1)300 (2)1200 mOsm
|
|
The more (1)the ascending limb extrudes, the more water diffuses out of the descending limb and the saltier the filtrate in the descending limb becomes
|
NaCl
|
|
The more NaCl the ascending limb extrudes, the more (1)diffuses out of the descending limb and the (2)the filtrate in the descending limb becomes
|
(1)water (2)saltier
|
|
Water diffusing out of the descending limb produces a (1)
|
salty filtrate that the ascending limb uses to raise the osmolaity of the medullary interstital fluid
|
|
(1)produces a salty filtrate that the ascending limb uses to raise the osmolaity of the medullary interstital fluid
|
water diffusing out of the descending limb
|
|
NAME
this establishes a postive feedback mechanism that produces the high osmolaltiy of the fluids in the descending limb and the interstitial fluid |
when water diffusing out of the descending limb produces a salty filtrate that the ascending limb uses to raise the osmolaity of the medullary interstital fluid
|
|
What does water diffusing out of the descending limb produces a salty filtrate that the ascending limb uses to raise the osmolaity of the medullary interstital fluid, help to establish?
|
establishes a postive feedback mechanism that produces the high osmolaltiy of the fluids in the descending limb and the interstitial fluid
|
|
What is the countercurrent exchanger?
|
refers to the vasa recta
|
|
NAME
this refers to the vasa recta |
countercurrent exchanger
|
|
What is the function of the countercurrent exchanger?
|
it functions in maaintaining the osmotic gradient established by the cycling of salt while delivering blood cells in the area
|
|
NAME
this functions in maintaining the the osmotic gradient established by the cycling of salt while delivering blood cells in the area |
the countercurrent exchanger
|
|
NAME
these blood vessels on recieve about 10% of the renal blood supply |
vasa recta
|
|
The vasa recta is extermely (1)
|
permeable to water and NaCL
|
|
NAME
this is extermly permeable to wter and NaCL |
vasa recta
|
|
As the blood flows into the medullary depths, it (1)
|
looses water and gains salt
|
|
NAME
this inhibits dieuresis |
ADH
|
|
What does the ADH stand for?
|
antidieurtic hormone
|
|
What is dieuresis?
|
refers to urine output
|
|
NAME
this refers to urine output |
dieruresis
|
|
What does the ADH hormone do?
|
inhibits dieuresis
|
|
Depending on (1) in the loop of Henle, the urine conecntration may reach as high as 1200 mOsm
|
the amount of ADH released
|
|
When maximal ADH secretion is up, 99 % of the water is (1)
|
reabsorbed and returned to the blood
|
|
ADH is released more or less continously unless (1)
|
the blood soulte concentration drops too low
|
|
NAME
this is released more or less continously unless the blood soulte conecntration drops to low |
ADH
|
|
When is ADH release enhanced?
|
by any event that raises osmolaity above 300 mOsm such as sweating or diarrhea
|
|
NAME
ths is released by any event that raises osmolaity above 300 mOsm such as sweating or diarrhea |
aDH
|
|
T or F
there are several types of diutertucs |
true
|
|
What are diuretics?
|
are chemicals that enhance urinary output
|
|
NAME
these are chemicals that enhance urinary output |
diuretics
|
|
What is a osmotic diuertic?
|
is a substance that is not reabsorbed and that carries water out with it
|
|
NAME
this is a substance that is not reabsorbed and that carries water out w it/ |
osmotic diuretic
|
|
Give a example of a diuretic?
|
Alcohol and caffine
|
|
NAME
alcholol is a example of this |
a dieuertic
|
|
What is one other way a substance can work a dieuertic?
|
by inhibiting Na+ reabsoprtion and the obligatory water reabsoprtion that normally follows
|
|
NAME
this can also incease urine output by inhibiting Na+ reabsorption and the obligatory water reabsorption that normally follows |
diuertic
|
|
What is a example a diuretic that works by inhibiting Na+ reabsorption and by the obligatory water reabsoprtion that normally follows?
|
caffeine and many drugs prescribed for hypertension or the edema of congestive heart faliure
|
|
NAME
a example of this is caffeine and many drugs prescribed for hypertension or the edema of congestive heart failure |
a diuretic that works by inhibiting Na+ reabsorption and by the obilgatory water reabsoprtion that normally follows
|
|
What are the symptoms of kidney trouble?
|
include high blood pressure, freqeunt, urination, diffuclt or painful urination, puffy eyes, or swollen hands or feet
|
|
NAME
some symptoms of this include high blood pressure, frequent, urination, puffy eyes, or swollen hands or feet |
kidney trouble
|
|
What can too much phosphorus do?
|
leache Calcium from the skelton and weakenes bones
|
|
NAME
this can leache Calcium from the skeleton and weakens the bones |
to much phosphorus
|
|
What can too much sodium do?
|
can raise blood pressure and cause ostperposis
|
|
NAME
this can raise your blood pressure and cause osteprosis |
too much sodium
|
|
What color is the urine?
|
clear and pale to deep yellow
|
|
NAME
this is a clear and pale to deep yellow color |
urine
|
|
What accounts for urine being a clear and plae to deep yellow color?
|
urochrome
|
|
What is urochrome?
|
is a pigment found in urine that gives it's color
|
|
What does urochrome result from?
|
the destruction of hemoglobin
|
|
NAME
this results from the destruction of hemoglobin |
urochrome
|
|
The more concentrated the urine, the deeper the (1)
|
yellow color
|
|
The more (1)the urine is, the deeper the yellow color
|
concentrated
|
|
What does the urine smell like?
|
aromatic
|
|
NAME
this smells aromatic |
urine
|
|
What is the pH of urine like?
|
slightly acidic
|
|
NAME
this is slightly acdic |
urine
|
|
A diet containing large amounts of protien and whole wheat products will (1)
|
turn urine acdic
|
|
A diet containing (1) will turn acdic
|
large amounts of protien and whole wheat products
|
|
What can cause the urine to become alkaline? (3)
|
(1)a vegetarian diet (2)prolonged vomiting (3)bacterial infection in the urinary tract
|
|
NAME
this can be caused by a vegetarin diet, prolonged vomiting, and bacterial infection in the urinary tract |
a alkaline urine
|
|
Which has a greater mass, a gallon of urine or distilled water?
|
urine
|
|
What is specfic gravity?
|
is the term used to compare the mass of a substance to the mass of an equal volume of distilled water
|
|
NAME
is the term used to compare the mass of a substance to the mass of an equal volume of distilled water |
specifc gravity
|
|
What is the specific gravity of urine?
|
about 1
|
|
What is the specific gravity of distilled water?
|
about 1
|
|
Water accounts for about (1) of urine vol
|
95%
|
|
Solutes accounts for about (1)of urine vol
|
5%
|
|
How much does water account for in urine vol?
|
95%
|
|
How much does solutes account for the vol of urine?
|
5 %
|
|
What is the largest component of weight aprat from water?
|
urea
|
|
NAME
this is the largest component of urine by weight aside from water |
urea
|
|
What are some nitrogenous wastes found in urine?
|
(1)urea (2)uric acid (3)creatinine
|
|
NAME
some of these include urea, uric acid, and creatinine |
nitrogenous wastes found in urine
|
|
What is creatinine?
|
is a metabolite of creatine phosphate which stores energy fo rthe regeneration of ATP and is found in large amounts in skeletal muscle tissues
|
|
NAME
is a metabolite of creatine phosphate which stores energy for the regeneration of ATP and is found in large amounts in the skeletal muscle tissues |
creatinine
|
|
What are the ureters?
|
are slender tubes that convey urine from the kidneys to the bladder
|
|
NAME
these are slender tubes that convery urine from the kidneys to the bladder |
ureters
|
|
The ureters are (1)layred
|
tri
|
|
What does the urter do?
|
it play an active role in transporting urine
|
|
NAME
this plays an active role in transporting urine |
ureters
|
|
What are kidney stones?
|
refers to on occasion when Ca, magnesium. or uric acid salts in urine may crystalize and precipate in the renal pelvis
|
|
NAME
this refers to when on occasion, when Ca, maganesium, or uric acid salts in urine may crysatlize and precipate in the renal pelvis |
kidney stones
|
|
What are renal calculi?
|
refesr to kidney stones
|
|
NAME
this refers to kidneys stones |
renal calculi
|
|
What is shock wave lithotripsy?
|
refers to a noninavise procedure that ues ultrasonic shock waves to shatter the calculi
|
|
NAME
this refesr to a noninavsive procedure that uses the ultrasonic shock waves to shatter the calculi |
lithotripsy
|
|
What is the urinary bladder?
|
is a smooth, collapsible, muscular sac that stores urine temporarily
|
|
NAME
this is a smooth, collapsible, muscular sac that stores urine temporarily |
urinary bladder
|
|
NAME
in men, this surrounds the bladder neck inferiorly |
the prostate gland
|
|
The protate gland surroundst the (1) inferiorly
|
bladder neck
|
|
What is the trigone?
|
refers to the smooth triagngular region of the bladder base outlined by three openings for both ureters and the urethra
|
|
NAME
this refers to the smooth triangular region of the bladder base outlined by three opening for both ureters and the uretha |
trigone
|
|
What are the three layers of the bladder (include the type of tissue for each layer? (3)
|
(1)mucosa with transitional epthielia (2)a thick muscular layer (3)a fibrous adventita
|
|
NAME
this has three layers: a mucosa containing transitional epithelioum, a thick muscular layer,and a fibrous adventitia |
bladder
|
|
What is the muscular layer of the bladder called?
|
the detrusor muscle
|
|
What is the detrusor muscle?
|
refers to the muscular layer that consists of intermingled smooth muslces fibers arranged in the inner and outer longitudinal layers and a middle circular layer
|
|
NAME
this refers to the muscular layer that consists of intermingled smooth muslces fibers arranged in the inner and outer longitudinal layers and a middle circular layer |
detrusor muscle
|
|
Why is the trigone clinically important?
|
bc infections tend to persist in this region
|
|
NAME
infections tend to persist in this regions |
trigone
|
|
What does the bladder do when it is empty?
|
is collapes into a basic pyramidal shape and its walls are thick and thrown into folds
|
|
NAME
when the bladder does this, it collapses into a basic pyramidal shape and its walls are thick and thrown into folds |
when the bladder is empty
|
|
What does the bladder do when urine accumulates?
|
the bladder exapands, becoming pear shaped and rises superiorly in the abdominal cavity
|
|
NAME
when the bladder does this, it expands becoming pear shape and rises superiorly in the abdominal caivty |
when the bladder accumulates urine
|
|
What is the maximum capacity of the bladder?
|
800-1000ml
|
|
NAME
the maxium capacity of this is 800 to 1000 ml |
the bladder
|