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15 Cards in this Set
- Front
- Back
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Global Control
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Regulatory mechanism that respond to envirn signals and effect many dif genes.
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What is an example of catabolite repression?
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E. coli diauxic growth
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What type of control mechanisms is the lactose operon subj to?
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both + and - control
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CAP (catabolite activator protein)
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Postive cntrl factor requires cyclic AMP as coactivator
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How is the lac operon neg cntrl?
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by the LacR repressor
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How is the lac operon pos cntrled?
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the glucose concentration through the activity of adenylyl cyclase.
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When is CAP bind to DNA?
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only when cAMP is bound.
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When does RNAP bind?
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When CAP is bound.
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Operon
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A single transcriptional unit (polycistronic mRNA) expressed coordinately from a single promotor and regulated by a common operator.
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Regulon
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A set of operons, whose locations vary on the chromosome, that are regulated by a common repressor or activator. Proucts of the operons are often related, members of the same pathway.
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Alternative sigma Factors
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Can alter the specificity of promptor recognition of the RNA polymerase holoenzyme.
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Two component regulators
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A common scheme in bacteria for responding to environ stimuli.
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What makes up a Two component regulator?
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Sensor Kinase and Response regulator
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Attenuation
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Refers to a regulatory process where the control occurs during transcription elongation. Controls the number of transcripts that go to completion.
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What are two important features of a leader region?
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1. The RNA produced by transcription of the leader region has multiple and competing secondary stuctures. One of these structures is an intrinsic terminator structure.
2. The leader reagion encodes a small peptide that has codons for Trp (or other AA). THis is the key feature it has codons related to biosynth pathway encoded by the operon. |
