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36 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What are the Catecholamines/Neurotransmitters?
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Epinephrine
Norepinephrine Dopamine |
Located at the end of neurotransmitters; transmits signal from each neuron
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Adrenergic/ Fight or flight
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Sympathetic
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Parasympathetic
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Body at rest; rest and digest
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Adrenergic is known as
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Adrenergic agonists
Sympathomimetics |
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Drugs that mimic the effects of the SNS neurotransmitters
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Epinephrine
Norepinephrine Dopamine |
Located on the END of the neurotransmitters
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Adrenergic Receptors
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Alpha-adrenergic receptors
Beta-adrenergic receptors Dopaminergic receptors (respond only to dopamine) |
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Alpha 1 location?
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Located on postsynaptic effector cells (the cell, muscle, or organ that the nerve stimulates)
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Alpha 2 location?
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Located on presynaptic nerve terminals (the nerve that stimulates the effector cells)
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Alpha-Adrenergic Agonist responses
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Vasoconstriction
CNS stimulation |
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Beta-Adrenergic Receptors location?
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Postsynaptic
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Beta 1 location?
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Heart
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Beta 2 location?
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Smooth muscle of the brinchioles, arterioles, and visceral organs
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Beta Adrenergic Agonist Responses
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Bronchical, GI, uterine smooth muscle relaxation, glycogenolysis, cardiac stimulation, dilating vessels
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What do Dopaminergic Receptors cause?
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Increase blood flow by dilation, happens in the following blood vessels: renal, mesenteric (around stomach area), coronary, cerebral
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Endogenous
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Develops from within the system (epinephrine, norepinephrine, dopamine)
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Synthetic
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Dobutamine (Beta 1)
Phenylephrine (Alpha 1) |
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MOA: Direct-acting sympathomimetic
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Binds directly to the receptor and causes a physiologic response
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MOA: Indirect-acting sympathomimetic
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Release of catecholamine from storage, then binds and causes a physiologic response
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MOA: Mixed-acting sympathomimetic
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Directly binds & indirectly binding
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Positive inotropic effect
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Increased force of contraction
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Positive chronotropic effect
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Increased heart rate
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Positive dromotropic effect
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Increased conduction through AV node
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Beta 2 treats?
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Asthma & Bronchitis
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Beta 2 Drugs
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Albuterol, Ephedrine, Epinephrine, Formoterol, Levalbuterol, Metaproterenol, Pirbuterol, Salmeterol, and Terbutaline
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Alpha 1 is used to treat?
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Nasal congestion
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Alpha is used to treat
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Conjunctival congestion (eyes), reduction of intraocular pressure, and dilation of pupils
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Medicine for Nasal Congestion
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Ephedrine
Naphazoline Oxymetazoline Pheylephrine Tetrahydrozoline |
"ine" ending, 1E 1N 1O 1P 1T
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Medicine for conjunctival congestion
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Epinephrine
Naphazoline Phenylephrine Tetrahydrozoline |
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Medicine for open-angle glaucoma
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Epinephrine
Dipivefrin |
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Pressors or Vasopressors cause what?
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Constriction
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Vasoactive Adrenergics
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Cardioselective Sympathomimetics
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Vasoactive Sympathomimetics medicine?
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Dobutamine
Dopamine Ephedrine Epinephrine Fenoldopam Midodrine Norepinephrine Phenylephrine |
2D 2E 1F 1M 1N 1P
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Alpha Adrenergic Adverse Effects
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CNS: Headach, restlessness, excitement, insomnia, euphoria
Cardiovascular: Palpitations (dysrhythmias), tachycardia, vasoconstriction, hypertension Other: Loss of appetite, dry mouth, nausea, vomiting, taste change (rare) |
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Beta Adrenergic Adverse Effects
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CNS: mild tremors, headach, nervousness, dizziness
Cardiovascular: increased HR, palpitations, fluctuation in BP Other: sweating, nausea, vomiting, muscle cramps |
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Interations with Adrenergic drugs?
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Anesthetic drugs
Tricycline antidepressants Monoamine Oxidase Inhibitors Antihistamines Thyroid preparations Adrenergic Antagonist |
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Salmeterol is used for what?
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Bronchospasms, not management of acute symptoms
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