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14 Cards in this Set
- Front
- Back
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cell immortality |
proliferative cell population |
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additional genetic changes that creates benign or malignant tumor |
early adenoma |
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metastases |
carcinoma |
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cancer causing genes in some types of viruses |
oncogenes |
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corresponding normal cellular genes that's responsible for normal cell growth & division |
proto-oncogenes |
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3 ways proto - oncogenes cn be converted to oncogenes |
1. movement of DNA within the genome (if it ends up near an active promoter transcription may increase 2. amplification of a proto oncogene: increases the # copies of genes 3. pt. mutations in the proto oncogene or its control elements: causes an increase in gene expression |
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normally helps prevents uncontrolled cell growth |
tumor suppressor genes |
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3 jobs of tumor suppressor proteins |
1. repair damaged DNA 2. control cell adhesion 3. acts in cell signaling pathway that inhibit cell cycle |
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mutations in what 2 genes are common in human cancers |
ras proto oncogene p53 tumor suppressor |
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mutations in what gene leads to production of a hyperactive ras protein & increase in cell division |
ras gene |
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produces proteins that accelerate cell cycle that causes cancer |
tumor viruses |
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produces one protein that inactivates a tumor suppressor protein |
HPV |
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v-oncogenes in ___ genome were hijacked from cell & altered to dysregulate cell cycle * often receptors, transcription factors, kinases |
RNA |
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v-onc in __ genome viruses aren't from cell & often function in virus replication |
DNA |
