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17 Cards in this Set
- Front
- Back
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What is the effect of alpha or beta stimulation in the CNS, peripheral postsynaptically or peripheral presynaptically?
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CNS Beta 2 - inhibits SNS -VD;
PPost - alpha 2 VC, Beta 2 VD; PPre - Beta increase NEpi, alpha 2 decrease NEpi; |
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Central Adrenergic Inhibitors (alpha 2 agonists) have what effect on the Sympathetic outflow from the medulla?
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Diminished outflow leading to decrease BP and HR.
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What condition is Alpha 2 agonists indicated?
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HTN, but not CHF because not potent enough Vasodilator.
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What are the side effects in Alpha 2 agonists?
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Sedation, dry mouth, bradycardia
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What is the mechanism of action of the sympathetic nerve ending antagonists, guanethidine and guanedrel?
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These drugs are taken up by the NE uptake pump and then by the synaptic vesicles. Here, they prevent the synaptic release of NE.
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What is the mechanism of action of the sympathetic nerve ending antagonist, reserpine?
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Reserpine inhibit NE synaptic vesicle uptake.
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In what condition is reserpine contraindicated?
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History of depression
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Alpha 2 Receptor feedback inhibition blockade results in what? So name (3) Alpha 1 selective antagonists and what they condition they treat.
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Greater Reflex Tachycardia; Prazosin, Terazosin and Doxazosin all treat HTN while T & D treat BPH.
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The nonselective alpha blockers, phentolamine and phenoxybenzamine, are used in treating what condition?
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Pheochromocytoma (tumor that abnormally secretes catecholamines)
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Beta adrenergic Receptor Antagonists are indicated in what conditions?
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IHD, HTN, CHF, Tachy-Arrhythmias
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What are the effects of Beta adrenergic Receptor Antagonists?
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Decreased inotropy, chronotropy, and conduction velocity.
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Toxicities such as AV node blockade, bronchospasm,, arterial vasospasm, or hypoglycemia can be related to what 3 adrenergic drug differences?
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Relative selectivity for specific subtypes of Beta 1 or 2; ISA activity; concomitant effect on alpha receptors
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TRUE/FALSE - Abrupt withdrawal of a Beta blocker can cause an Acute Myocardial Infarction in patients with underlying CAD.
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True
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Beta adrenergic Receptor Antagonists are indicated in what conditions?
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IHD, HTN, CHF, Tachy-Arrhythmias
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What are the effects of Beta adrenergic Receptor Antagonists?
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Decreased inotropy, chronotropy, and conduction velocity.
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Toxicities of Beta blockers can cause AV node block, bronchospasm,reduction of HDL, arterial vasospasm, or hypoglycemia recovery. What 3 receptor differences account for this?
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Relative selectivity for specific subtypes of Beta 1 or 2; ISA activity; concomitant effect on alpha receptors
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TRUE/FALSE - Abrupt withdrawal of a Beta blocker can cause an Acute Myocardial Infarction in patients with underlying CAD.
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True
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