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19 Cards in this Set
- Front
- Back
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Adaptive Immunity |
Our body that is adapting to a pathogen and responding appropriately (3rd line of defense) |
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Characteristics of Adaptive Immunity (A SIM U) |
Ability to clonality Specific Inducibility Memory Unresponsive to self |
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Components of Adaptive Immunity |
B and T cells |
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B cells |
Originate as stem cells -made in bone marrow and differentiate from stem cells -they then migrate to other lymph tissues in the body •waiting to encounter potential pathogens -involved in hummoral Immunity |
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T Cells |
Made in thymus gland -differentiate from stem cells -migrate to other lymph tissues •also waiting in tissues to encounter potential pathogens |
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Antigen-Antibody Interaction |
Another name for PAMPs |
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Antigens |
Are composed of epitopes (individual patterns on antigen) -very different depending on the foreign particle. |
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MHC (major histocompatibility complex) |
B cells show MHC on the plasma membrane of their cells for the T cells to see like a "silver platter" |
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Selection/Deletion of clones |
Specific to B cells - stem cells in the bone marrow make many B cells, if B cells bind to autoantigens the apoptosis If not, then it will never interact with any of our cells and it is good to go into the blood |
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Autoantigens |
Our antigens |
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T dependant B cell activation |
T and B cells work together -B cells bind to extracellular antigen (very specific) -antigen is taken into the cell and put onto chemcial MHC -MHC proteins and antigens presented on B cell surface -T cell releases cytokines to active B cells -B cells transforms into plasma cells , creating antibodies |
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Agglutination |
Act of clumping pathogens with antibodies resulting in immobilization -now easier seen by phagocyte to go through phagocytosis |
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T cell independent B cell activation |
-repeated binding to epitopes on a surface = activation .....B cells will be activated and transform into plasma cells to make specific antibodies •this is a weaker response tho so no memory cells are made |
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Antigen Binding Results |
Agglutination, opsonization, neutralization, activation of Complement, antibody dependant cell mediated cytotoxicity |
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Opsonization |
Helping the macrophages find the pathogen and bind to them for the specific result of phagocytosis |
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Neutralization |
Antibodies are coating bacteria , toxins, and viruses so they cannot cause disease |
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Activation of Complement |
-antibody coat target organisms -complement binds FC region of antibody starting complement cascade |
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Antibody dependant cell mediated cytotoxicity |
:target organism coated with antibodies |
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Naturally acquired Immunity |
You interact with the pathogen naturally then u get disease once, memory cells are set aside and you never get it again |
