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25 Cards in this Set

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  • Back
Primary configuration of anitbodies
Two heavy chain proteins and two light chain proteins held together by disulfide bond
B-lymphocytes produce
Antibodies
Antibodies are more commonly called
Immunoglobulins (Ig)
Agglutination
Binding of foreign cells into a complex that prevents attachment to host cells and enhances phagocytosis
Neutralization
Binding of immunoglobulins to exotoxins
Immunoglobulins that bind to exotoxins
Antitoxins
Opsonization
Process which facilitates the binding of an immunoglobulin to an antigenic capsule aiding phagocyctisis
IgG
Most common, 85% of all Ig's
Agglutinate cells
Trigger complement
Be an opsonin and antitoxin
IgM
Second most common Ig
Ten reactive sites
Most efficient Ig for pathogens in blood
IgA
Function as monomer
Usually found as dimer, joined with J chain protein
Secretory component allowing exit in saliva, tears, and milk
IgE
Very low concentration in serum
Attaches to basophiles and mast cells
Signals release of histamine
IgD
Membrane bound on surface of B-lymphocyte
Specific antigen receptor
B-Cell receptor (BCR)
250,000 - 500,000 configurations
Three subtypes of T-Cells
Cytotoxic T-Cells
Type I Helper T-Cells
Type II Helper T-Cells
Cytotoxic T-Cells
CD8 glycoprotein
Sometimes referred to as T8 cell
Will kill pathogenic and self cells
Type I Helper T-Cells
CD4 and CD26 glycoprotein
CCD5 cytokine receptor
Assist action action of
Cytotoxic T-Cells
Type II Helper T-Cells
CD4 glycoprotein
CCR3 and CCR4 cytokine receptors
Regulate activity of B-Cells
Cytokines
Chemical messengers that move information from one type of body cell to another
3 types of Cytokines
Interleukins (ILs)
Interferons (INFs)
Tumor necrosis factors (TNFs)
Major Histocompatability Complex (MHC)
Glycoprotein and antigenic determinant complex found on the surface of all nucleated cells
Two types of antigen processing
Exogenous Antigen Processing
Endogenous Antigen Processing
Exogenous Antigen Processing
Phagosome engulfs pathogen
Inside phagosome antigenic determinants
Vesicle with MHC Type II merges with phagosome
Antigenic determinants bind to appropriate MHC
Phagosome fuse's will cell membrane, exposing complex
Endogenous Antigen Processing
Pathogens inside host cell
Antigens catabolized releasing antigenic determinants
At ER, bind with MHC Type I
Bound determinants migrate to golgi body, released as vesicle
Determinant bound MHC's exposed
2 types of B-Cell Activation
T-independent antigens
T-dependant antigens
T-independent antigens
Antigens w/ exposed determinants bind directly with BCR
B-Cell becomes activated
B-Cell coded to produce antigen specific antibodies
B-Cell>plasma cells>anitbodies
T-dependant antigens
Activated Type II Helper T-Cell binds to B-Cell w/ appropriate MHC II receptor
CD4 glycoprotein stablizes
Helper T-Cell secretes interluekin-4, activating B-Cell
B-Cell coded to produce antigen specific antibodies
B-Cell>plasma cells>anitbodies
Plasma cells become memory B-Cells