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10 Cards in this Set
- Front
- Back
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How soon does a body start to reject an allograft?
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Immediately, the body accepts the graft. After 10-13 days, however, the body begins to reject the graft.
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If you put a second transplant into a person, how soon after will the body reject the graft?
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Almost immediately b/c the immune system was primed.
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Which MHC molecule is the MAJOR player in graft rejection?
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Type I, type II can affect, but isn't as rapid.
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Which immune cells are responsible for the rapid rejection of the transplant of a second organ into a patient?
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T cells
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What are the two paths to transplant rejection?
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Direct allorecognition (Donor Dendritic cell Depletion) and Indirect allorecognition (the recipient mounts a new immune response).
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Explain Direct allorecognition
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Donor dendritic cells go straight to the recipient's lymph nodes and present Ag, stimulating recipient T cells. Acute rejection occurs very, very quickly b/c the APCs were primed and ready to go.
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Explain Indirect allorecognition
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Recipient APCs process and present graft Ag. This is slower than direct allorecogntion.
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When does hypeacute graft rejection occur? How do you prevent it?
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when their is preexisting Ab to donor graft blood Ags. Typically occurs when their was a previous blood transfusion. Cross match Ab in whole blood b/t donor and recipient.
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What happens in graft vs. host disease? How do you prevent this?
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if HLA type isn't matched, when a immunocompetent donor lymphocytes (from bone marrow transplant e.g.) reject recipient tissue.
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What two factors determine transplant success?
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HLA (MHC) matching and immunosuppressive therapy.
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