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47 Cards in this Set
- Front
- Back
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What is Signal 1 of APC - Tc |
MHC - TCR/CD3 |
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What is Signal 2 of APC - Tc |
Costim: Cd80/86 - CD28 or ICOS |
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What is Signal 3 of APC-Tc |
Cytokines (IL-2 for Activation, which increase rate and duration of Cell cycle) |
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What happens if there is no Signal 2? |
T cell anergy |
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T/F MHC 1 is ubiquitous throughout most cells |
T |
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Where is most MHC2 found |
prof. APC like DC B-cells too |
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What happens when CD4 T cells see Ag from APC? |
Secrete cytokines that +/- regulate: B cells Macrophages Other T cells |
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What are the 5 populations of effector T cells and where do they come from? |
Th1 Th2 Th17 iTreg Tfh Come from CD4!! |
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What T cells enhance CMI and Inflammatory processes? |
Th1 and Th17 |
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What T cells enhance humoral immunity |
Th2 and Tfh |
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What T cells inhibit T cell responses |
Tregs |
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T/F Generation of memroy B cells only requires T cell help |
F; B memory , CD4 memory and CD8 memory |
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What are the 2 types of memory t cells |
Tcm - Central Memory Tem - Effector memory |
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3 Facts about Tcm |
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2 Facts about Tem |
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Will naive T cell interaction with DC in presence of CTLA-4 Ig lead to anergy? |
Yes; signal 2 blocked |
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Will naive T cell stimulated with Ab that bind both the TCR and CD28 lead to anergy? |
NO; both Signal 1 and 2 are generated |
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Will naive t cell stimulated wtih Ab that bind only the TCR lead to anergy? |
Yes; Signal 1 but no signal 2 |
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Will naive t cell stimulated with Ab that only binds CD28 lead to anergy? |
No. but no activation either; neither signal 1 or 2 |
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T/F DCs can activate T cells in the skin |
F; LN! Memory T cells may be activated though |
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T/F TCR activity leads to Ca holding |
F; Calcium release |
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What polarizing cytokine is needed for Th1 lineage |
IL-12 |
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T/F Following activation both Tcm and Tem are generated |
T |
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Master transcriptional regulator for Th2 |
GATA3; if missing will have trouble clearing worms. Th2 cells help B cells produce IgE |
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T/F IgE is important for anti-parasite |
T |
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What cytokines/ Ab would you want to activate Th1 |
Signal 1: Anti-TCR Signal 2: Anti-CD28 Signal 3: IL-12 Anti-CTLA4 and Anti-CD80 would block costim |
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T/F ICOS is a positive co-stim molecule |
T |
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What 3 cells express Co-stim ligands |
APCs Thymic cells Epithelial cells |
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What can bind CD80/86 on DCs |
ICOS CTLA4 |
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T/F Naive T cells express Cytokines |
F |
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What transcriptional Regulator is involved with Tfh |
Tbet |
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Where do Tcms reside? |
2ndary Lymphoid Tissue |
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What R attracts cells to 2ndary LT and effecter cells to rome periphery |
CCR7 |
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TGF-B stimulates what Transcriptional regulators? |
FoxP3 RORgt |
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What do IL-6 + TGFB make via RORgt? What does it inhibit |
Th17; FoxP3 |
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Endogenous Ag come from |
Viruses (MHC1) |
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Exongenous Ag come from |
Bacteria, Parasites etc (MHC2) |
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LFA-1 on CD4 T cells binds what on APC |
ICAM-1 |
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CD2 on CD4 T cell binds what on APC |
LFA-3 |
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Which has a higher affinity for CD80/86? CTLA-4 or CD28 |
CTLA4 (neg stimulation) |
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Where is PD-1 found |
T CELLS |
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In what ways does a Th1 activation block Th2 activation |
Stat4 leads to T-bet which inhibits GATA3 Increased IFN-G and lowered IL-4 and IL-5 |
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In what ways does a Th2 activation block Th1 activation |
Stat 6 leads to GATA3 which inhibits Tbet Increased IL-4 and IL-5, lowered IFN-G |
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When is CD44 activated on T cells |
After Activation |
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Why are CD62L and CCR7 downregulated in T cells post activation |
So they can circulate |
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3 Hallmarks of T-cell memory |
Less sensitivity of co-stimulation Accelerated More specific |
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What are super Ag |
Ag made by pathogens that GREATLY increase T cell activation for non specific peptide |
