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11 Cards in this Set
- Front
- Back
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What are desirable properties of induction agents?
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Rapid and smooth onset and recovery
analgesia Minimal cardiac and respiratory depression Antiemetic actions bronchodilation lack of toxicity or histamine release |
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What were the first intravenous agents used for anesthesia?
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Opioids
However not until the 1930's when barbiturates were introduced they were not taken seriously. |
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Even thought there have been 2000 barbiturates what is the one of choice?
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Thiopental
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Barbituric acid is a cyclic compound from the condensation of ______ and _______?
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Urea
Malonic acid |
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Barbituric acid does or does not have CNS depressant activity?
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No it does not but derivatives of barbituric acid are categorized as barbiturates.
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By replacing both hydrogen atoms at position ____ with ____ or _____ groups, the pharmacologic action is as a sedative-hypnotic.
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5 position
alkyl or aryl groups |
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These derivatives of barbituric acid are known as _______ or as the ____ barbiturates.
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oxybarbiturates
true barbiturates |
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Although _________ in water, barbiturates are _______ in nonpolar solvents such as chloroform and oil.
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Insoluble in water
Soluble in nonpolar This is common in organic CNS depressants. |
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Barbs have relatively _____ onset of actions and a ______ duration.
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slower onset
prolonged duration |
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Longer chains result in _______potency.
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Higher
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The replacement of the number 2 carbon atom of the barbituric acid molecule with a a sulfur atoms produces what?
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Thiobarbiturates (thiopental)
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