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14 Cards in this Set
- Front
- Back
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what do you begin with when you make RNA?
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ntp (NUCLEOTIDE TRIPHOSPHATE)
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what regulates RNA transcription?
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repressors- slow down or prevent transcription
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what is polymerase I used on?
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pre-ribosomal RNA
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what is polymerase II used on?
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mRNA's and some specialized RNA's
many factors involved with |
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what is polymerase III used on?
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tRNAs ans some small specialized RNA'
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which two drugs are intercalators and inhibit polymerase activity?
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Actinomycin D adn Acridine
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which dru inhibits polymerase activity for M. tuberculosis?
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Rifampicin
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what is intercalation?
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insert themselves in DNA helix and remains bounds, therefore prevents transcription
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what is human tumor suppressor protein p53?
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it is a transcription factor that inhibits the transcription of some genes, while promoting others, mutations alter these activities and becomes a problem, results may be unregulated cell growth: carcinogenesis
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3 steps of mrna processing?
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5' cap, poly A tail 3' end, splicing (self-group I and group II introns or nonself-spliceosomes involving ribonucleoprotein snRNP's and tRNAs requires endonuclease)
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steps of rRNA processing?
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methylation and cleavage
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steps of tRNA processing?
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piece of 5' end is cut out, piece of 3' end is cut out, CCA addition at 3' end, modify bases
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what are ribozymes?
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RNA enzymes involved in RNA metabolism
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what is the average half-life of rna in vertebrates?
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3 hrs
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