Challenge Bowl Hemeonc

Front 1

Gram positive cocci in clumps is a typical formation for which microorganism?

Back 1

Staphylococcus spp

Front 2

Lactrodectus mactans is the Latin name for what?

Back 2

Black widow spider

Front 3

What is the test used to detect the presence of antibodies directed against RBC antigens?

Back 3

Coombs test

Front 4

Migratory thrombophlebitis that arises due to malignancy is named after who?

Back 4

Trousseau

Front 5

What organism causes Chagas' disease?

Back 5

Tyrpansoma cruzi

Front 6

What is the most common form of leukemia in children?

Back 6

ALL

Front 7

A developmental abnormality composed of disorganized cells or tissue native to the site it is in is known as what?

Back 7

Hamartoma

Front 8

Normal histologic tissue that occurs in the wrong place in the body is known as what?

Back 8

Choristoma (ex: Normal pancreatic tissue in the intestines)

Front 9

Leser-Trelat sign indicates possible malignancy with the sudden appearance of what?

Back 9

Multiple seborrheic keratoses

Front 10

A translocation between chromosomes 9 and 22 is most characteristic of what type of cancer?

Back 10

CML (Philadelphia chromosome)

Front 11

A translocation between chromosomes 9 and 22 is known as what?

Back 11

Philadelphia chromosome

Front 12

What hematologic factor increases significantly during allergic and parasitic reactions?

Back 12

Eosinophils

Front 13

What is the myeloproliferative disorder characterized by excessive RBC production?

Back 13

Polycythemia vera

Front 14

What virus is associated with Burkitt's lymphoma?

Back 14

Epstein Barr virus

Front 15

A translocation between chromosomes 8 and 14 is associated with what cancer?

Back 15

Burkitt's lymphoma

Front 16

What enzyme is responsible for the inactivation of penicillin class antibiotics?

Back 16

Beta lactamase

Front 17

What antibody class is involved in the secondary response to an antigen?

Back 17

IgG

Front 18

A 42 year old man presents with weakness, DOE, and midthoracic back pain. On PE he was found to have vertebral tenderness on palpation and pallor. Labs reveal hypercalcemia, anemia, ESR elevation, and an elevated creatinine. A bone marrow sample reveals plasma cells predominantly. What is the most likely diagnosis?

Back 18

Multiple myeloma

Front 19

What protein found on urinalysis is commonly associated with multiple myeloma?

Back 19

Bence Jones protein

Front 20

A 5 year old child whose family lives in a dilapidated house presents with lethargy and cognitive defects. The mother reports that from time to time the child ingests paint chips. What is the most likely diagnosis?

Back 20

Lead poisoning

Front 21

Wrist drop in a lethargic child with developmental delays is indicative of what condition?

Back 21

Lead poisoning

Front 22

In what site are aged and damaged RBCs destroyed primarily by macrophages?

Back 22

Spleen

Front 23

Deficiency of what vitamin is most likely to produce a bleeding disorder?

Back 23

Vitamin K

Front 24

A 54 year old male recovering alcoholic who is also being treated with Coumadin for DVT develops an elevated prothrombin time after being prescribed a new medication as part of his rehab. What is probably the new drug?

Back 24

Disulfuram (metabolized by CYP450 as is Coumadin so enhances effects)

Front 25

What antibody class is the main antibody in secretions (e.g. saliva, tears, GI secretions)?

Back 25

IgA

Front 26

What would be completely absent in the peripheral circulation of an infant born without a thymus?

Back 26

T-lymphocytes

Front 27

Pellagra is a deficiency of what vitamin?

Back 27

Niacin (Vitamin B3, nicotinic acid)

Front 28

Coagulation factor VIII is also known as what?

Back 28

von Willebrand's factor

Front 29

Birbeck granules are found in what cells?

Back 29

Langerhans cells

Front 30

Which immunoglobulin is implicated in the development of allergic reactions?

Back 30

IgE

Front 31

What antibody class is involved in the primary response to an antigen?

Back 31

IgM

Front 32

Reye's syndrome is associated with the administration of what drug in children?

Back 32

Aspirin

Front 33

Fever, conjunctival injection, erythema & swelling of palms, soles, & lips, skin exanthems, and lymph node enlargement are seen in what disease?

Back 33

Kawasaki disease (may also see strawberry red tongue)

Front 34

The influx of what ion is normally seen with cell death due to ischemia?

Back 34

Calcium

Front 35

Negri bodies are pathognomic for what disease?

Back 35

Rabies

Front 36

What are the vitamin K dependent clotting factors?

Back 36

2, 7, 9, 10

Front 37

A starry sky pattern on a bone marrow smear indicates what?

Back 37

Burkitt's lymphoma

Front 38

What are the fat soluble vitamins?

Back 38

A, D, E, K

Front 39

Patients with Hemophilia A are deficient in which clotting factor?

Back 39

Factor VIII

Front 40

About how long is the lifespan of a human RBC?

Back 40

120 days

Front 41

What are the granules seen in the body of erythrocytes after splenectomy?

Back 41

Howell Jolly bodies