Histocompatibility 1

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Histocompatibility genes

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Genes that determine tissue compatibility between individuals

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Major Histocompatibility Complex (MHC)

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Genetic region that controlled tissue graft rejection and contained several linked genes

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MHC genes

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Control immune responsiveness to protein antigens

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human leukocyte antigens (HLA)

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Human MHC molecules are called

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human leukocyte antigens (HLA)

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equivalent to the H-2 molecules of mice.

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MHC Genes

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involved in presenting peptides from antigen

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class I

class II MHC genes

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two types of polymorphic MHC genes

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TRUE

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encode two groups of structurally distinct but homologous proteins.

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MHC genes

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most polymorphic genes present in the genome

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True

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MHC genes are codominantly expressed in each individual

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MHC

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Tightly linked cluster of genes whose products are associated with intracellular recognition and self/nonself discrimination

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MHC

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Bind peptide fragments derived from pathogens and display them on the cell surface for recognition.

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MHC molecules

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Antigen-presenting cells use receptors called ______ to bind and present antigens

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TRUE

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Central role in development of humoral and cell-mediated immune response

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An extracellular peptide-binding cleft, or groove,

Immunoglobulin (lg) -like domains Transmembrane domains Cytoplasmic domain

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Structure of MHC

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Class I molecules

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are composed of 1 polypeptide chain encoded in the MHC and a second, non-MHC encoded chain

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Class II molecules

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made up of 2 MHC encoded polypeptide chains.

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adjacent to the peptide binding cleft

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The polymorphic amino acid residues of MHC molecules are located in and ______

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polymorphic amino acid residues of MHC molecules

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responsible in holding and conformational presentation of antigen-derived peptides

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nonpolymorphic Ig-like domains of MHC molecules

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contain binding sites for the T cell molecules CD4+ and CD8+.