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63 Cards in this Set

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Depression

A mood state characterized by sadness despair feeling of worthlessness (futility) and withdrawal from others

Mania

Mental state characterized by elevated mood and excessive excitement energy or irritability with impairment in social and occupational functioning

Affective symptoms of depression

Feelings of hopelessness worthlessness low self-esteem limited enthusiasm four things that previously brought pleasure and joy and anxiety


Cognitive symptoms of depression

-Pessimistic beliefs about present and future


-inability to concentrate


-negative thinking


-loss of interest and motivation


-suicidal Thoughts


- irrational or unjustified beliefs


-Self-denigration and rumination

Self-denigration

Belittling oneself or feelings of incompetence thoughts of suicide

Rumination

Continually thinking about certain topics or reviewing events that have transpired(happened)

Behavioral symptoms of depression

-Fatigue lethargy social withdrawal reduced work productivity diminished motivation poor hygiene slow speech agitated and Restless


-Anhedonia is also prevalent

Anhedonia

Loss of the capacity to derive pleasure from normally pleasant experiences

Physiological symptoms

-Appetite and weight changes (increase it decrease eating)


-Sleep disturbances (insomnia or hypersomnia)


-Aches and pains


-Aversion to sexual activity (reduced sex drive)

Hypomania

Mild level of manic intensity


Increased levels of activity and goal-directed behaviors combined with an elevated expansive or irritable mood

Characteristics of hypomania

Does not involve:


-a loss of contact with reality (psychosis)


-Or impairment in Social and occupational functioning


-or a need for hospitalization


Involves:


Increased productivity decreased need for sleep and generate many disconnected ideas


Form goals that are unfinished

Affective symptoms of mania

Volatility (change rapidly and unpredictably) from extreme elation to intense rage


Inappropriate humor lack of restraint and expressing feelings or opinions and grandiosity

Grandiosity

Overvaluation of one significance or importance and and being Superior

Cognitive symptoms of mania

Disorientation intrusive thoughts lack of focus and attention poor judgement and lack of insight regarding inappropriateness of behaviors and verbiage


Failure to evaluate consequences of decisions


Communication and speech can be difficult to interpret

Behavioral symptoms

-Act impulsively socially destructive behavior


Speech is rapid and unclear


Difficulty delaying gratification


Wild excitement ranting raving constant movement & agitation


Paranoia hallucinations delusions


Can become a danger to self and others

Physiological symptoms of mania

Decreased need for sleep and high levels of arousal


Minimal fatigue and ongoing restlessness


intense activity


Increased libido and hypersexuality


Weight loss due to energy

What are some specifiers to consider when diagnosing a mood disorder?

1. Mixed features:


Symptoms from the other ends of the mood continuum


Exhibiting milder symptoms from the opposite pole


2. Suicide risk severity:


Socio-cultural variables, comorbid anxiety, personality or substance use disorder, feelings of worthlessness, suicidal behavior


Any past or current indicators of suicide


3. Postpartum onset:


Depression after childbirth


Affects 13% of women


Mood congruent

Consistent or realted the individuals mood state

Psychotic symptoms that are mood congruent

Delusions or hallucinations are consistent with depressive moods (themes of inadequacy death guilt or punishment)

Psychotic symptoms that are incongruent

Delusions or hallucinations that are unrelated to depressive mood (beliefs of being controlled by aliens) Indicates a more severe illness and greater cognitive impairment


Catatonia

Unresponsive to external stimuli such as mutism, taking a specific posture and not moving, extreme agitation with purposeless excessive motor activity


Occurs frequently with schizophrenia


Schizoaffective disorder

Someone with a psychotic disorder who experiences prolonged episodes of mania or major depression

How is the diagnosis of a depressive disorder based?

Based on severity and chronicity of depressive symptoms as well as pattern of symptom development

Major depressive episode

Two week period involving major episodes of feelings of sadness/ emptiness and or loss of Interest in previously enjoyed activities

Major depressive disorder (MDD)

-Occurrence of at least one major depressive episode for two weeks


- weight or appetite changes, changes in sleep patterns, fatigue, low energy, and recurrent thoughts of death or suicide


No history of mania or hypomania

Chronic depressive disorder (CDD) or dysthymia

-Depressed mood has lasted for at least 2 years with no more than 2 months symptom-free


- ongoing presence of at least two of the following: hopelessness, low self-esteem, poor appetite, low energy,


- negative world view, pessimistic outlook on future

Mixed anxiety / depression (MAD)

-Simultaneously experience significant anxiety symptoms (anxious distress) along with..


- multiple symptoms of major depression including depressed mood and or anhedonia


- neither anxiety nor depression is clearly predominant


** associated with longer depressive episodes and higher risk of suicide


Seasonal affective disorder (SAD)

-Major depression occurs with a seasonal pattern associated with decreasing light


- at least two major depressive episodes occurring during fall / winter and remitting(stop) in Spring / summer


- seasonal episodes of depression outnumber non-seasonal episodes


- associated with vegetative symptoms

Anxious distress

Symptoms of motor tension difficulty relaxing pervasive worries or feelings that something catastrophic will occur

Vegetative symptoms

Declining energy, lethargy, increased need for Sleep, carbohydrate craving associated with weight gain, and social withdrawal

Premenstrual dysphoric disorder (PMDD)

-Severe depression, mood swings, anxiety or irritability occurring before the onset of Menses for at least one year


- at least five symptoms must occur


- similar to PMS however interferes with social and interpersonal relationships or academic / occupational functioning

Epidemiology of depressive disorders

- leading cause of worldwide disability


- 15 million Americans experience disorder a year


- 50 billion spent annually on Healthcare and lost work days


- being female Native American middle-aged Widow to separated or divorced are having low income increases risk


- African Americans 40% less likely than whites to experience it however they have more severe and chronic depression


- 15% fail to show any significant remission of symptoms and many of these cases represent undiagnosed bipolar disorder

Role of heredity in the etiology of depression

-tends to run in families, because higher among biological families compared to adoptive families


- carriers of the shorter allele of serotonin transporter gene release more stress hormone when mistreated as children


- have difficulty absorbing and releasing serotonin (needed for effective neurotransmission)


Role of circadian disturbances and depression

- Rhythm allows adaptation to factors occurring in the external environment


- light related changes affecting secretion of the hormone melatonin and serotonin regulation


- insomnia worsens depressive symptoms


- exhibit REM sleep

Role of Abnormal cortisol levels in depression

- register higher blood levels of cortisol which deplete the chemicals (serotonin) necessary for effective neurotransmission


- immune system dysfunction resulting in brain inflammation and the formation of neurotoxins


- exposure to stress during early development affects cortisol levels and HPA system


- stress the timing of stress (increases cortisol release) and genetic predisposition can interact to produce depression


Stress circuitry and depression

-Stress increases levels of cortisol


- cortisol restores homeostasis by signaling the brain to dampen HPA activity


- high levels of cortisol can damage hippocampus resulting in dysregulation of stress circuitry


- chronic stress depletes serotonin and affect the production of them science necessary for serotonin to metabolize

Role of neurotransmitters and depressive

-Depletion of neurotransmitters elevates depression


-Anti depressant medication increases availibility of neurotransmission and helps normalize HPA function and facilitate regeneration of neurons

Neuroanatomy and depression

-HPA axis alterations as well as smaller hippocampal volume might be predicted by stress dysregulation


- decreased activation of prefrontal lobes associated with MDD


- decreased brain activity due to reduction in Gray matter

Behavioral explanations of depression

-Insufficient social reinforcement due to losses such as unemployment divorce or death of a loved one


- results from changes in a custom level of reinforcement (love affection companionship)


- depression can be reduced by increasing activity that generates environmental reinforcement


-Lewinsohn's law

Lewinsohn's law of depression

Low rates of positive reinforcement due to:


1. The number of events and activities that are potentially reinforcing to the person


(Age, gender, biological traits may determine availability of reinforcers)


2. The availability of reinforcements in the environment


(Harsh/ isolating enviroment)


3. The instrumental behavior of the infant individual


-(social interactions)


*Stress plays a major role by destructing well-established behavioral patterns


Lack of positive reinforcement increasing adversative experiences

Cognitive explanation of depression

-The experience of negative thoughts and errors in thinking result in pessimism negative self perception feelings of hopelessness and depression


- have exaggerated irrational and catastrophic thinking patterns


- the development of schemas reducing disturbance in thinking(Beck's theory)


- have memory bias of recalling more negative words and depressing events so presumably have developed negative schemas


- cope with stressful circumstances via rumination or co-rumination


- have difficulty using positive events to regulate negative mood


Schemas

Cognitive framework that helps organize & interpret information


** can create depression by perpetuating a negative outlook and attention to negative messages / tendency to focus on negative information

Beck's Theory (4 negative skemas)

1. Arbitrary inference


-Drawing conclusions not supported by evidence


2. Selected abstraction


- focus on minor incidents or trivial details taken out of context


(a minor comment)


3. Overgeneralization


- drawing conclusions about their ability performance or worth from a single experience or incident


4. Magnification and minimization


- magnify or exaggerated limitations and difficulties and minimize accomplishments achievements and capabilities

Rumination

Repeatedly thinking about concerns or events

Co-rumination

Constantly talking over problems with peers

Seligman's Behavioral and cognitive learning theory

Both cognition and feelings of helplessness are learned


So depression results from learned helplessness


Those who feel helpless make depressive causal attributions

Learned helplessness

Belief that one is helpless and unable to affect outcomes in one's life

Seligman's Causal attributions (examples on page 229)

Speculations about why events occur


Which can be eaither:


-Internal or external


- stable or unstable


- Global or specific


** individuals whose speculations are internal, stable, and global are likely to have feelings of depression

Beck's Theory versus Seligman's theory

Results tended ro support Beck's Theory


High levels of a negative cognition coupled with stress predicted subsequent depression while negative attributional style did not result in greater depression

Social dimension of the etiology of depression

-Maltreatment, death of or abandonment by a parent, parental depression


-Adopted infants exhibit high levels of reaction to frustration when mother demonstrates high levels of depression


- interpersonal stress such as problems with dependency


-Psychosocial stress such as life-threatening medical condition, frustration regarding major life goals, and death of loved one


- timing of onset, type, and severity of stress are important indicators that determine the likelihood of depression


- social support and resources can help individuals cope and adjust to stress which is important for remission



Socio-cultural dimension on the etiology of depression

Includes socioeconomic status culture race ethnicity and gender

Culture ethnicity and depression

-May create distinctive and environments for gene expression and physiological reaction


- In some cultures maybe experience largely in the form of somatic or bottle bodily complaints rather than as sadness or guilt


- perceived discrimination increased depressive symptoms

Gender and depressive disorders

-Far more common among women regardless of region in the world race and ethnicity


-Differences May reflect differences and self-report or willingness to seek treatment


- Heritability is higher among women than in men


- ruminating and Co-ruminating more common in women


- hormone secretion patterns, menopause, traditional gender roles, increased vulnerability to interpersonal stress

Treatment for depression

Includes medication, circadian related treatments, brain stimulation Therapies, Psychotherapy and behavioral treatments



** adjunctive therapy ( adding on to therapy) is preferred over switching from one therapy to another

Medications used for depression

-Antidepressants which increase the availability of neural communication


- continuation of medication is necessary to prevent against return of symptoms


-Discontinuation syndrome flu like symptoms intense fatigue insomnia or increase emotionality and irritability or suicidal thinking


- unfortunately many individuals do not respond to antidepressant medication and less than 1/3 experience full remission of symptoms

Circadian related treatments for depression

Treats SAD


-The use of bright light spectrum or blue wavelengths


-Light therapy influence circadian rhythm by stimulating photoreceptor system


-Involves dawn like stimulation (timer activated light that gradually increases in brightness) or daily use of box visor or lighting system that delivers light of a particular intensity for a period of time


-Advantages include absence of side effects and more rapid treatment response and maybe as beneficial as antidepressant treatment

Brain stimulation Therapies for depression

Electroconvulsive therapy (ECT):


-Involves application of moderate electrical voltage to the brain in order to produce seizures lasting for 15 seconds


-FDA approved


- considered a first line treatment for life-threatening depressive symptoms


Vegas nerve stimulation:


-Approved for use if prior treatment has failed


-Combined with ECT


Transcranial magnetic stimulation:


- electromagnetic field stimulates the brain ( has received some support as well as skepticism)

Behavioral activation therapy( BAT) for depression

Treatment involves increasing exposure to pleasurable events and activities improving social skills and facilitating social interaction


STEPS:


1. Identifying and rating different activities in terms of pleasure and mastery


2. Performing selected activities hence increasing feelings of pleasure or mastery


3. Identify problems and using Behavior techniques to deal with them


4. Improving social and assertiveness skills

Interpersonal psychotherapy (ITP) for depression

- focused on current problems and altering current/present relationship patterns


- uses psychodynamic, cognitive behavioral, and other forms of therapy


- relationship issues are the targets of therapy and strive to improve Communications with others, identifying role conflicts, and increasing social skills

Cognitive behavioral therapy for depression

- focuses on altering extreme negative thought patterns


- helps individuals:


1. Identify negative thoughts


2. No connection between negative thoughts and subsequent


3. Examine the negative thoughts and decide if it is true


4. Replace distorted negative thoughts with a realistic interpretations


-also aim to eliminate ruminative positive thoughts and negative metacognition



*** individuals treated with CBT are less likely to relapse

Ruminative positive thoughts

Worry helps me overcome my problems

Negative metacognition

Other people reject me if I worry too much

Mindfulness-based cognitive therapy (MBCT) for depression

Involves calm awareness of one's present experience thoughts feelings and having an attitude of acceptance rather than being judgemental


- disrupt cycle of negative thinking by focusing on the present