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5 Cards in this Set
- Front
- Back
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Which of the following steps in the biosynthesis of cholesterol is the committed rate-limiting step? A. The condensation of acetoacetyl-CoA with a m olecule of acetyl-CoA to yield -hydroxy--methylglutarylCoA (HMG-CoA) B. The reduction of HMG-CoA to mevalonate C. The conversion of mevalonate to two activated isoprenes D. The formation of farnesyl pyrophosphate E. Condensation of six activated isoprene units to form squalene |
B. The reduction of HMG-CoA to mevalonate
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Considering the final steps in cholesterol biosynthesis, when squalene is eventually converted to lanosterol, which of the following statements is correct? A. All of the sterols have three fused rings (the s teroid nucleus) and are alcohols with a hydroxyl group at C3. B. The action of squalene monooxygenase oxidizes C14 of the squalene chain, forming an epoxide. C. Squalene monooxygenase is considered a mixedfunction oxidase because it catalyzes a reaction in which only one of the oxygen atoms of O2 is incorporated into the organic substrate. D. Squalene monooxygenase uses reduced flavin nucleotides, such as FAD(2H), as the cosubstrate in the reaction. E. Squalene is joined at carbons 1 and 30 to form the fused-ring structure of sterols. |
C. Squalene monooxygenase is considered a mixedfunction oxidase because it catalyzes a reaction in which only one of the oxygen atoms of O2 is incorporated into the organic substrate.
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Of the major risk factors for the development of atherosclerotic cardiovascular disease (ASCVD), such as sedentary lifestyle, obesity, cigarette smoking, diabetes mellitus, hypertension, and hyperlipidemia, which one, if present, is the only risk factor in a given patient without a history of having had a myocardial infarction that requires that the therapeutic goal for the serum LDL cholesterol level be 100 mg/dL? A. Obesity B. Cigarette smoking C. Diabetes mellitus D. Hypertension E. Sedentary lifestyle |
C. Diabetes mellitus
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Which one of the following apoproteins acts as a cofactor activator of the enzyme lipoprotein lipase (LPL)? A. ApoCIII B. ApoCII C. ApoB100 D. ApoB48s E. ApoE |
B. ApoCII
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Which one of the following sequences places the lipoproteins in the order of most dense to least dense? A. HDL/VLDL/chylomicrons/LDL B. HDL/LDL/VLDL/chylomicrons C. LDL/chylomicrons/HDL/VLDL D. VLDL/chylomicrons/LDL/HDL E. LDL/chylomicrons/VLDL/HDL |
B. HDL/LDL/VLDL/chylomicrons
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