Ch.15 Bacterial Virulence Factors

Front 1

Bacterial Virulence Factors

Back 1

They help the pathogen evade the host's defenses, and result in invasion

Front 2

B.V.F - Capsules

Back 2

A B.V.F that resists host defenses by preventing up phagocytosis

Front 3

B.V.F- Cell Wall Components

Back 3

Protein M, Waxes, Opa Protein

Front 4

Opa Protein

Back 4

An outer membrane protein that inhibits T helper cells

A cell wall component in gonorrhea bacteria that attaches to the host cell

Front 5

Waxy lipid in Mycobacteria (TB)

Back 5

Increases virulence by resisting digestion by phagocytosis

Front 6

Extracellular Enzymes

Back 6

Affect the host and make it easier for the pathogen

Front 7

E.E - Leukocidins

Back 7

Found in Staph. and Strep.

Destroys neutrophils to prevent phagocytosis

Front 8

E.E - Hemolysins

Back 8

Cause red blood cells and white blood cells to lyse

Found in Strep.

Front 9

Enzymes and Virulence

Back 9

Help the bacteria get to where they need to be

[C.H.I.CK.]

Front 10

Enzyme Coagulase

Back 10

Forms a clot around the cell and protects it from phagocytosis; the cell hides in the clot

Ex: S.auerus (TSS)

Front 11

Enzyme Kinase

Back 11

Digests Fibrin clots so the body isn't able to isolate the infection; allows microorganism to spread away from the site of infection

Front 12

Enzyme Hyaluronidase

Back 12

Allows the m/o to penetrate the tissue by breaking down what holds certain cells together, and can help spread the infection

Front 13

Enzyme Collagenase

Back 13

Breaks down the collagen protein which forms connective tissue

Front 14

Enzyme IgA Proteases

Back 14

Destroys the IgA antibodies that the body makes to prevent adherence of bacteria;

When the IgA antibodies are destroyed, the bacteria can adhere

Front 15

Antigenic Variation

Back 15

Alters surface proteins in bacteria so then surface antigens are different from the initial surface antigens and cannot be fought by the antibodies that the body produced