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10 Cards in this Set
- Front
- Back
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What is the age group for ALL?
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newborn to 14
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What are the subtypes of ALL?
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Early pre-Bcell ALL 80%
PRE-B, B-, and T-cell ALL |
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What is the pathogenesis of ALL?
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Clonal expansion of lymphoid stem cells
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What is the most common acute leukemia in children?
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ALL
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What are the positive marker studies for Early Pre-B-cell ALL?
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1.CD10
2.Tdt: terminal doxynucleotidyl transferase |
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What translocation has favorable outcome for ALL
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t12:21
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What is percent of remission in Pre-B-cell ALL?
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90% achieve complete remission
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What are the clinical findings for ALL?
IE B-cell metasis and T-cell metastasis |
B-cell , Commonly metastasize to the CNS and testicles
T-cell- anterior mediastinal mass or acute leukemia |
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What are Lab Findings for ALL?
WBC Anemia Bone Marrow |
WBC 10,000-100,000/uL
**Over 20% lymphoblast in smear Normocytic with thrombocytopenia Bone marrow replaced by Lymphocytes |
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What are the markers for T-cell ALL?
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CD10 negative and TdT positive
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