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5 Cards in this Set
- Front
- Back
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What is the pathogenesis of Myelofibrosis or Myeloid Metaplasia?
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1. Marrow Fibrosis occurs earlier than other types of myeloproliferative disease
2. Neoplastic cells are produced in the Spleen and other sites |
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What are the clinical findings of Myelofibrosis?
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1. Massive splenomegaly with portal hypertension
2. Splenic infarcts with left-sided pleural effusions |
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What are the Lab findings in Myelofibrosis?
WBC Anemia Bone Marrow Platelet |
WBC = 10,000 -50,000/ul
Normocytic Anemia Fibrosis in Bone Marrow due to Fibroblast Platelet varaible ( increase or decrease) |
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What would the anemia look like?
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1. Tear drop cells ( RBC damage)
2. Leukoeythoblastic rxn |
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How would you describe the peripheral blood smear?
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Numerous reticulocytes with a blue discoloration, nucleated RBC, and metamyelocyte, and tear drops FIGURE 12-1
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