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4 Cards in this Set
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Serum Levels:
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Monitoring of serum levels is common, as the same aminoglycoside dose can produce very different plasma levels in different patients.
Peak levels must be high enough to kill bacteria; Trough levels must be low enough to minimize toxicity. |
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Other Aminoglycosides:
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*anything ending in -mycin
Tobramycin [Nebcin] Amikacin [Amikin] Netilmicin [Netromycin] Neomycin Kanamycin [Kantrex] Streptomycin Paromomycin [Humatin] Tobramycin [Nebcin] Amikacin [Amikin] Netilmicin [Netromycin] Neomycin Kanamycin [Kantrex] Streptomycin Paromomycin [Humatin] |
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Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
[Overview] [USE] [AV] |
*Used for very very SERIOUS gram – infections*
*Individualized therapy* -Can cause serious injury to inner ear and kidney -Narrow spectrum antibiotic -Microbial resistance- aminoglycoside inactivating enzymes Use: aerobic gram-negative bacilli Adverse effects: -Nephrotoxicity -Ototoxicity |
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Gentamicin [Garamycin]
infections caused by? [USES] PaKSPm [AV] |
Serious infections caused by aerobic gram-negative bacilli
[Uses] Pseudomonas aeruginosa Escherichia coli Klebsiella Serratia – Proteus mirabilis [Adverse effects] Nephrotoxicity Ototoxicity |
