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10 Cards in this Set
- Front
- Back
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Broad spectrum antibiotic.
[Action] |
-Inhibits 30s ribosomal protein synthesis
-Much resistance-tetracycline pump |
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Broad spectrum antibiotic.
[USES] [ABSORBED] |
-Rickettsial disease
-Chlamydia trachomatis -Brucellosis -Cholera -Mycoplasma pneumoniae -Lyme disease -Anthrax -Helicobacter pylori -Acne -Absorption—chelation: Calcium supplements, milk products, iron supplements, magnesium-containing laxatives, and most antacids |
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Broad spectrum antibiotic.
[Adverse Effects] |
Adverse effects:
-Gastrointestinal -Effect on bone and teeth -Superinfection -Hepatotoxicity -Nephrotoxicity |
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Macrolides
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-Erythromycin
-Azithromycin |
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Erythromycin
[Action] [AV] |
Erythromycin
Broad spectrum antibiotic. Similar spectrum to PCN . MOA-blocks 50s ribosomal protein synthesis inside cell -Use if allergic to penicillin** Adverse effects: Gastrointestinal Cholestatic hepatitis Superinfection |
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Azithromycin
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Azithromycin = Macrolide
-Half life is 68-72 hrs -Once drug of choice for inner ear infection, now ~50% resistance. -5 day course equivalent to about 21 days of therapy -N/V present but less than erythromycin |
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Clindamycin [Cleocin]
[Action] [AV] |
-Inhibits 50s ribosomal protein synthesis.
-Can induce antibiotic-associated pseudomembranous colitis. -Indicated only for certain anaerobic infections located outside the CNS. Adverse effects Antibiotic-associated pseudomembranous colitis Hepatic toxicity – Blood dyscrasias Nepthrotoxicity – Diarrhea – Hypersensitivity reactions |
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Linezolid
(oxazolidinones) [Action] [Use] |
First member of NEW class of antibiotics—oxazolidinones
MOA:Binds 30s and 23s subunits, blocks protein systhesis Associated with bone marrow suppression Use: Active against multidrug-resistant gram-positive pathogens (i.e., vancomycin-resistant enterococci (VRE), methicillin-resistant Staph aureus (MRSA) |
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Chloramphenicol [Chloromycetin]
[USES] [AV] |
Broad spectrum antibiotic
Inhibits protein synthesis-50s Uses : Only for life-threatening infections for which safer drugs are ineffective or contraindicated Adverse effects: -Reversible bone marrow depression -Aplastic anemia -Gray syndrome -GI effects -Peripheral neuropathy |
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Tigecycline-Tygacil
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Blocks 30s ribosomal subunit, which stops protein synthesis .
-Hits VRE, MRSA, C.diff -Bacteria unable to pump out. |
